Abstract: A business solution development process having one or more pre-definition stages and one or more post-deployment stages is disclosed. In accordance with one embodiment of the invention, data pertinent to an understanding of a business is analyzed and a future state of the business is envisioned. One or more desired outcomes necessary to attaining the envisioned future state of the business are then determined. One or more transformations that will effect each desired outcome are determined and implemented to attain the envisioned future state of the business.

Abstract: This disclosure provides several methods to generate nucleic acid mutations in vivo, for instance in such a way that no heterologous sequence is retained after the mutagenesis is complete. The methods employ integrative recombinant oligonucleotides (IROs). Specific examples of the described mutagenesis methods enable site-specific point mutations, deletions, and insertions. Also provided are methods that enable multiple rounds of mutation and random mutagenesis in a localized region. The described methods are applicable to any organism that has a homologous recombination system.

Abstract: The invention is directed to a method of making a yeast artificial chromosome (YAC) comprising introducing into yeast cells a population of nucleic acids and a vector, wherein the vector comprises a yeast centromere, a selectable marker, a yeast telomere, and a sequence which can recombine with a region of a nucleic acid within the population of nucleic acids, whereby in vivo recombination makes the YAC. The invention is also directed to a method of making a YAC using two vectors and a method of making a circular YAC. The invention is also directed toward methods of making YACs with a selected nucleic acid insert from a mixed population of nucleic acids using transformation-associated recombination.

Abstract: An illuminated, kiosk type, display stand designed for use in holding and attractively displaying various articles of merchandise or other items or materials. The stand is formed of a pair of hollow, molded plastic, front and rear units that are secured to each other and mounted on a separate base unit.

Abstract: The present invention relates, in general, to endo-exonucleases. In particular, the present invention relates to DNA segments encoding for a polypeptide having an amino acid sequence corresponding to mammalian endo-exonuclease, a polypeptide having an amino acid sequence corresponding to mammalian endo-exonuclease, antibodies to mammalian endo-exonuclease, a recombinant DNA molecule, mutant cells substantially lacking endo-exonuclease activity, a cell containing mammalian endo-exonuclease, and methods of producing and using the polypeptide, DNA segment and mutants.

Abstract: A portable, personal, medicine cabinet arrangement for holding medicines and other items required to help maintain a prescribed medication schedule for an individual. The cabinet includes a hollow body, forming a compartment with at least one shelf for holding medicines, and a pair of inner and outer hinged covers having spaces for storing various items of printed material. The material held by the inner cover can be read from either side of the cover.

Abstract: A sensitive, yeast-based genetic system for identifying agents causing double-strand DNA damage is described. The system comprises a yeast strain containing either chromosomes having divergent (homeologous) DNA sequences, a single nonhomologous chromosome or a single artificial chromosome with suitable genetic markers so that double-strand damage leading to the loss of such chromosome due to the inability to undergo recombinational repair with a homolog is detected.

Abstract: A method of producing plasmids with heteroduplex DNA sequences, in which probe plasmids containing DNA inserts that correspond to probe sequences and test plasmids containing DNA inserts that correspond to a population of test sequences are first constructed. The vector portions of the plasmids used in these constructions have similar sequences. When test and probe plasmids are cleaved with appropriate restriction enzymes and then denatured to separate strands, complementary regions of the linear strands which correspond to vector sequences can anneal. The molecules that harbor test and probe inserts that are related by sequence complementarity form non-covalently closed circular molecules. These molecules can replicate after transformation into an appropriate host organism. There is a replication bias against plasmids which anneal through vector sequences, but which do not contain homologous probe and test inserts.

Abstract: The present invention relates, in general, to a DNA segment. In particular, the present invention relates to a DNA segment coding for a polypeptide having an amino acid sequence corresponding to RhoNUC, a polypeptide having an amino acid sequence corresponding to RhoNUC, antibodies to RhoNUC, a recombinant DNA molecule, a cell containing the recombinant DNA molecule, and methods of producing and using the polypeptide and DNA segment.

Abstract: A display container for holding, displaying, and dispensing articles such as literature and samples. The container is formed from several paperboard components and has a tubular body with upper and lower insert pieces positioned within the body to divide the interior of the body into separate compartments, one of which is adapted to hold a drawer that can be pulled out from the body.

Abstract: There is disclosed herein an apparatus for forming container blanks from cardboard or other paperboard-like substrates. The apparatus includes a press, platens, a coated plate member, and a die-and-knife assembly. The coating on the plate is impressible for accommodating irregularities in the machine, platen surface, or knife so as to permit the knife edges to substantially lie in a cutting plane. The coating is generally an organic coating which is liquid just above room temperature and solid at room temperature. The impressions are made in the coating and the coating is then hardened for use by polymerization such as by ultraviolet light.

Abstract: There is disclosed herein an apparatus for forming container blanks from cardboard or other paperboard-like substrates. The apparatus includes a press, platens, a coated plate member, and a die-and-knife assembly. The coating on the plate is impressible by the back edge of the knife for accommodating irregularities in the machine, platen surface, or knife so as to permit the knife edges to substantially lie in a cutting plane. The coating is generally an organic coating which is liquid just above room temperature and solid at room temperature. The impressions are made in the coating and the coating is then hardened for use by polymerization such as by ultraviolet light.