Abstract: An apparatus for holding a tissue specimen during imaging is provided. The tissue specimen has a 3D geometry and a region of interest. The apparatus includes a cover panel and a specimen support structure. The cover panel has upper and bottom panel surfaces and a viewing aperture that extends between the upper and bottom panel surfaces. The specimen support structure is configured to support the tissue specimen in an imaging orientation. The specimen support structure is configured to permit alignment of the tissue specimen ROI with the viewing aperture. The apparatus is configurable in a secured configuration in which the specimen support structure is positionally fixed relative to the cover panel, the tissue specimen ROI is exposed through the viewing aperture for imaging, and the tissue specimen ROI is held motionless relative to the cover panel.

Abstract: A system and method for determining the presence of cancerous tissue within a tissue cavity is provided. The system includes one or more excitation light sources, a photodetector, a probe, and a system controller. The probe includes an optically transparent probe body configured to fit within the tissue cavity. The system controller is in communication with the excitation light sources, the photodetector, and a memory storing instructions. The instructions when executed cause the system controller to a) control the excitation light sources to produce excitation light beams within the probe body, the excitation light beams operable to produce a response of the tissue to the interrogation and control the photodetector to detect the response and produce signals representative thereof; and b) produce information indicative of a presence of the cancerous tissue using the signals representative of the response.

Abstract: A tumor responsive tissue marking dye is provided that includes a tissue marking dye and at least one cancer activated agent. The at least one cancer activated agent is configured to assume a first state in the absence of cancerous tissue or a microenvironment associated with said cancerous tissue, and a second state in the presence of said cancerous tissue or said microenvironment associated with said cancerous tissue, wherein the first state is photometrically distinguishable from the second state.

Abstract: A portable flow measuring apparatus includes an array of pressure sensors used to measure the acoustic and convective pressure variations in the flow to determine a desired parameter. A portable processing instrument processes the signals provided by the sensing array to provide an output signal indicative of a parameter of the fluid flow. The portable processing instrument includes a processor having appropriate processing algorithms to determine the desired or selected parameter(s) of the process flow 12. The portable processing instrument has a user interface to permit the user to select the parameters to be measured in the process flow, and/or more importantly, to enable the user to modify particular parameters or functions in the processor 30 and/or processing algorithms. The user interface 32 also enables a user to modify the code of the algorithm via a graphic user interface (GUI), keyboard and/or user input signal 34.

Abstract: A portable flow measuring apparatus measures the speed of sound and/or vortical disturbances propagating in a fluid flow to determine a parameter of the flow propagating through a pipe. The apparatus includes a sensing device that includes an array of pressure sensors, which may be removable, used to measure the acoustic and convective pressure variations in the flow to determine a desired parameter. A portable processing instrument processes the signals provided by the sensing array to provide an output signal indicative of a parameter of the fluid flow. The portable processing instrument includes a processor having appropriate processing algorithms to determine the desired or selected parameter(s) of the process flow 12. The portable processing instrument has a user interface to permit the user to select the parameters to be measured in the process flow, and/or more importantly, to enable the user to modify particular parameters or functions in the processor 30 and/or processing algorithms.

Abstract: A system for vertical seismic profiling of an earth borehole includes an optical fiber having a plurality of Bragg grating sensors formed therein, each one of the Bragg grating sensors being tuned to reflect a respective bandwidth of light, each bandwidth having a different respective central wavelength. Each of the Bragg grating sensors are responsive to an input light signal, a static strain, a dynamic strain and a temperature strain for each providing a respective light signal indicative of static and dynamic forces and temperature at a respective sensor location. The physical spacing and wavelength spacing of the Bragg grating sensors are known such that each of the sensing light signals are easily correlated to a specific depth.

Abstract: A method of collating unfolded sheets of paper into a collation and combining the collation with a folded sheet of paper. The method comprises: feeding a plurality of unfolded sheets of paper seriatim along a feed path from an upstream position to a downstream position; conveying the unfolded sheets seriatim around a drum to cause the unfolded sheets to be conveyed to an upstream position; stopping the unfolded sheets seriatim in a pocket having a back panel and a top panel, the back panel stopping the unfolded sheets from being conveyed further upstream and forming a collation of the unfolded sheets; feeding a folded document having a leading folded edge from an upstream to a downstream position across the top panel on top of the collation of unfolded sheets, thereby forming a single stack of documents; and conveying the single stack of documents to a downstream location.