Abstract: One example of an internet protocol (IP) keyboard, video, mouse (KVM) device includes a universal serial bus, a display port, a network port, and a processor. The USB port is to be communicatively coupled to a host device. The display port is to be communicatively coupled to the host device. The network port is to be communicatively coupled to a network. The processor is communicatively coupled to the USB port, the display port, and the network port. The processor is to receive, via the display port, a multi-stream transport (MST) DisplayPort signal; demux the MST DisplayPort signal to provide a plurality of individual video streams; and output, via the network port, each individual video stream.

Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Operating a gaseous fuel engine system includes combusting a mixture containing a gaseous hydrogen fuel and air in a cylinder of an engine, varying an operating parameter of the engine to which a crown surface temperature of a piston within the cylinder is responsive, and populating a temperature model based on a value of the varied operating parameter. Operating a gaseous fuel engine system further includes operating an oil spray apparatus to spray oil onto the piston based on the populated temperature model, and maintaining the crown surface temperature of the piston between a high temperature limit and a pre-ignition mitigation temperature limit based on the operating of the oil spray apparatus. Related apparatus and control logic is also disclosed.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A method and system for incrementally revising designated portions of content contained in a medium to provide a new edition and/or a revised edition of the medium, the method including assigning a unique identifier to each element of the content contained in the source version; creating for each element of the content, at least one of a change set file, a logical content store file, or a definition file; receiving from a first author a first modification to a discrete portion of the content, the first modification further comprising: a logical intent of the first author for the first modification, a purpose of the first author for the first modification, or a goal of the first author for the first modification; storing the first modification in a corresponding first change set file; receiving from a second author a second modification to the discrete portion of the content, the second modification further comprising: a logical intent of the second author for the second modification, a purpose of the second a

Abstract: This disclosure relates to methods for the treatment of neoplastic disorders by administering Compound 1, or a pharmaceutically acceptably salt thereof, on its own and/or as part of a conjugate or composition, and inducing production of at least one neoantigen.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A system and method for processing leaded glass are presented, in which glass input is tumbled within the cylinder of a ball mill while it is being exposed to an electrolytic fluid. As the glass input is tumbled, balls within the ball mill pulverize the glass input into pulverized glass input particulate matter thereby exposing lead or other heavy metals contained within the glass input to a surface of the pulverized glass input particulate matter. The exposed lead or other heavy metals are largely dissolved by the electrolytic fluid leaving a mostly lead or heavy metal free pulverized glass input particulate matter. A reagent is applied to the pulverized glass input particulate matter to neutralize any residual lead or heavy metal within the pulverized glass input particulate matter thereby allowing the processed pulverized glass input particulate matter to pass a Toxicity Characteristic Leaching Procedure (TCLP) environmental test.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A method and system for incrementally revising designated portions of content contained in a medium to provide a new edition and/or a revised edition of the medium, the method including assigning a unique identifier to each element of the content contained in the source version; creating for each element of the content, at least one of a change set file, a logical content store file, or a definition file; receiving from a first author a first modification to a discrete portion of the content, the first modification further comprising: a logical intent of the first author for the first modification, a purpose of the first author for the first modification, or a goal of the first author for the first modification; storing the first modification in a corresponding first change set file; receiving from a second author a second modification to the discrete portion of the content, the second modification further comprising: a logical intent of the second author for the second modification, a purpose of the second a

Abstract: An apparatus for conveying one or more objects along a conveying path in a conveying direction includes an endless conveyor chain formed of modular links arranged in rows in a direction transverse to the conveying direction. The links include spaced outer side links forming a part of a conveying surface for the objects to be conveyed and intermediate links interconnected with side links by connector rods, the chain having at least a forward run for conveying one or more objects in the conveying direction. A driver is provided for driving the conveyor chain, and includes a first sprocket adapted for engaging at least one side link along at least one side of the chain, the first sprocket mounted for rotation about an axis generally orthogonal to the conveying direction and the transverse direction. The sprocket may comprise a split sprocket, and may be adapted for pivoting movement.

Abstract: An apparatus for conveying one or more objects along a conveying path in a conveying direction includes an endless conveyor chain formed of modular links arranged in rows in a direction transverse to the conveying direction. The links include spaced outer side links forming a part of a conveying surface for the objects to be conveyed and intermediate links interconnected with side links by connector rods, the chain having at least a forward run for conveying one or more objects in the conveying direction. A driver is provided for driving the conveyor chain, and includes a first sprocket adapted for engaging at least one side link along at least one side of the chain, the first sprocket mounted for rotation about an axis generally orthogonal to the conveying direction and the transverse direction. The sprocket may comprise a split sprocket, and may be adapted for pivoting movement.

Abstract: The invention includes genetically modified dendritic cells expressing at least two immunosuppressive molecules. The genetically modified dendritic cells have the ability to induce tolerance. Enhanced tolerogenicity is useful for prolonging survival of a foreign transplant and for treatment of autoimmune diseases.

Abstract: An apparatus for adjusting a computer work station to individual needs including a frame having a keyboard support attached thereto. A vertical adjustment mechanism operatively attached to the frame permits the keyboard support to be adjusted vertically up or down. Also, a pivotal adjustment mechanism is operably attached to the frame and to the keyboard support for permitting the keyboard support to be adjustably pivoted about a substantially horizontal axis. A monitor support is provided and has a horizontal adjustment mechanism operably attached to the frame for selectively moving a monitor support toward or away from the keyboard support and the monitor support also can be adjusted vertically by a separate vertical adjustment mechanism. The adjusting mechanisms for the keyboard support and the monitor support are electrically controlled by the computer user. An adjustable wrist support and an adjustable foot support are also provided.