Abstract: The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, ring A, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.

Abstract: The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.

Abstract: The invention relates to the use of compounds in the treatment of deacetylase-associated diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.

Abstract: The invention relates to pharmaceutical compositions containing inhibitors of histone deacetylase and B vitamins and methods of use thereof, in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.

Abstract: The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.

Abstract: The present invention is directed to a helical drill configuration that allows substantially flat bottomed holes to be machined. At the cutting end of the body member, there are at least two cutting edges that are symmetrically oriented on opposing sides of the rotational axis of the drill. In an embodiment of the invention, first and second cutting edge portions form a continuous surface which provides strength and tool stability. The height of the second portions of each of the cutting edges remains relatively consistent along the horizontal for formation of a generally flat bottom hole. In the embodiment, a center point is defined by two sloped peak surfaces. A central straight chisel edge is formed by the intersection of the two sloped peak surfaces. The first cutting edge section extends from the chisel edge to the second cutting edge section. The first cutting edge section for both cutting edges is formed by symmetrically thinning the two peak surface.

Abstract: A system, apparatus and method for detecting defects in a honeycomb body. The system and apparatus include a fixture adapted to hold the honeycomb body, a particulate fluid source, a pipe which defines a flow path between the particulate fluid source and a first end face of the honeycomb body thereby allowing particulate fluid to flow from the particulate fluid source to the first end face of the honeycomb body. The particulate fluid emerges at a second end face of the honeycomb body through defects, if any, in the honeycomb body where the positions of such defects may be monitored. The system and apparatus includes a flow straightener disposed in the flow path to minimize boundary layer influence of the pipe on the flow of the particulate fluid. A substantially uniform velocity flow profile is provided to the first end face of the honeycomb body.

Abstract: A twist drill including a cutting tip having a front flank face, a substantially cylindrical tool body extending rearwardly from the cutting tip, and a shank. The tool body includes a rotational axis therethrough and at least one flute formed on an outer peripheral surface thereof and extending to the front flank face. The at least one flute includes a first helical portion opening to the front flank face and a second helical portion extending from the rear end of the first helical portion toward the rear portion of the tool body. The second helical portion twists in a direction opposite of the first helical portion.

Abstract: A method for delivering a plurality of reactor monoliths into an interior of a reactor includes providing at least one tubular member having an outer wall defining an interior space adapted to allow sliding movement of reactor monolith therethrough, and providing a plurality of engagement members located within the interior space of the at least one tubular member and spaced along a length thereof, wherein each engagement member is actuable between an extended position and a retracted position. The at least one tubular member is extended into an interior of a reactor such that a first end of the at least one tubular member is located near an opening in the reactor, and a second end of the at least one tubular member is insert into the interior of the reactor.

Abstract: A rotary cutting tool that is composed of a tool shank with at least one chucking groove or chip flute and one exchangeable cutting insert. At the tip of the shank a recess for accommodating the cutting insert is provided. The tool shank, on its circumference, has a limb with a bearing surface that is inclined relative to the tool axis and that corresponds to a likewise inclined bearing surface on a wing of the cutting insert. The inclination of the bearing surfaces produces an axial force that retains the cutting insert on the tool shank. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.

Abstract: The invention relates to transactional analysis for identifying obvious and nonobvious relationships between target database documents and source database documents. It is particularly applicable to processes for searching, analyzing and operating on transactional and historical data found in remote and disparate databases for uncovering non-obvious or fuzzy relationships between people, places and events, and finding links and dependencies that would not otherwise be identifiable within a set of data.