Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, Ra5, Ra6, Ra7, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to a composite material, to a method for the production thereof, and to a fire protection element containing the composite material according to the invention for the protection of passage openings in components in the event of fire, such as building parts, through which conduits are guided. The present invention further relates to the use of the composite material as a fire protection element for sealing passage openings and/or joints in components.

Abstract: A computer-implemented method for selectively applying at least one crop protection product onto an agricultural field (40), comprising the following steps: —providing image data of at least a part of an agricultural field (40) which is to be treated with a crop protection product; —providing a crop planting row identification model (63) configured to identify crop planting rows (42) in the image data of the at least one part of the agricultural field (40); —providing a weed plant detection model (65) configured to detect weed plants (46) between the identified crop planting rows (42); —providing a crop and weed detection model (67) configured to detect crop plants (41) and weed plants (46) in the identified crop planting rows (42); —applying a first crop protection product (44) onto a weed plant (46) detected between the identified crop planting rows (42); —applying the first crop protection product (44) onto a weed plant (46) detected in the identified crop planting rows (42), if a distance between the weed

Abstract: Methods and devices for transvascular placement of electrodes in on a surface of a brain or in deep brain structures for the purpose of neuromodulation.

Abstract: Establishing communication between first and second digital twins, a first REST-based API assigned to the first digital twin and a second REST-based API assigned to the second digital twin includes transmitting a request to an endpoint of the first API and receiving a response therefrom, and transmitting a request to an endpoint of the second API and receiving a response therefrom. The responses are compared and analyzed. A mapping model is created on the basis of the comparing and analyzing, the mapping model containing semantic and technical requirements of the first API and of the second API. The mapping model is used for mutual communication between the first digital twin and the second digital twin, the mapping model translating a data transfer from one of the two digital twins in a manner conforming to the technical and semantic requirements of the API of the other of the two digital twins.

Abstract: Systems and methods providing a processing device to receive, by a software build process executing in a trusted execution environment (TEE) of a first computer system, software source code from a second computer system. The processing device generates a software package by compiling the software source code. The processing device also receives, from the second computer system, a signing key associated with the second computer system. The processing device further signs the software package using the signing key associated with the second computer system. The processing device then deploys the signed software package on the first computer system.

Abstract: Methods, systems, and computer program products for gathering electronic signatures to be applied to collaboration system content objects (e.g., contracts, letters, insurance claims, riders, etc.). A collaboration system monitors changes made to the collaboration system content objects during electronic signature processing. A module of the content management system is configured to associate one or more instances of e-signing metadata to one or more of the stored content objects of the content management system. The e-signing metadata indicates whether or not a particular portion of the one or more of the stored content objects has been e-signed by a designated e-signatory. A collaborator who is not one of the designated e-signatories makes a change to one or more of the stored content objects (e.g., contracts, letters, insurance claims, riders, etc.). The change is remediated on-the-fly and the e-signing process continues without having to restart the e-signing process from the beginning.

Abstract: All X-ray computerized tomography systems that are available or proposed base their reconstructions on measurements that integrate over energy. X-ray tubes produce a broad spectrum of photon energies and a great deal of information can be derived by measuring changes in the transmitted spectrum. We show that for any material, complete energy spectral information may be summarized by a few constants which are independent of energy. A technique is presented which uses simple, low-resolution, energy spectrum measurements and conventional computerized tomography techniques to calculate these constants at every point within a cross-section of an object. For comparable accuracy, patient dose is shown to be approximately the same as that produced by conventional systems. Possible uses of energy spectral information for diagnosis are presented.

Abstract: A computer system and method generates one or more commenting features on a canvas, wherein each commenting feature carries at least one comment from a given source. Each commenting feature can include a pin component and a comment body element. The pin component is associated with a corresponding location on the canvas. The computer system and method enable the user to move the comment body element about at least a region of the canvas to view the at least one comment from the given source, while rendering the pin component to coincide with the corresponding associated location of the canvas.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: A unified network service that connects multiple disparate private networks and end user client devices operating on separate networks is described. The multiple disparate private networks and end user client devices connect to a distributed cloud computing network that provides routing services, security services, and performance services, and that can be controlled consistently regardless of the connection type. The unified network service provides uniform access control at the L3 layer (e.g., at the IP layer) or at a higher layer using user identity information (e.g., a zero-trust model). The disparate private networks are run on top of the distributed cloud computing network. The virtual routing layer of the distributed cloud computing network allows customers of the service to have private resources visible only to client devices (e.g.

Abstract: A railborne driver assistance device for supporting or automating the lateral control of a vehicle includes a first processing unit configured to control a steering torque intervention by establishing a steering angle with a stationary control accuracy of an electrically supported steering system. A second processing unit is configured to adjust the stationary control accuracy of the steering angle via the output of an accuracy request signal to the first processing unit in such a way that there is a scaling of the control accuracy between a lower and an upper threshold value. The second processing unit includes a control unit having an integrator with an input and an output, wherein the output of the integrator is connected to the input in a closed-loop manner with a weighting dependent on the accuracy request signal.

Abstract: An electronic device for improving a performance of a signal chain is described. The signal chain includes multiple electronic components. The electronic device further includes a control circuit. The control circuit is configured to receive a set of figures of merit, wherein the set of figures of merit includes at least one component-specific figure of merit for several different settings of several of the electronic components, respectively. The control circuit is configured to determine and/or receive at least one n-th moment characteristic of a signal of the signal chain. The control circuit is configured to determine at least one performance parameter for a plurality of different combinations of settings of the electronic components, respectively, wherein the at least one performance parameter is indicative of a performance of the signal chain.

Abstract: Embodiments of the present disclosure relate to methods of finding optimized analog measurement hardware settings of a measurement system for a target measurement. The method can include one or more of the following steps: applying initial settings to the measurement system; varying the settings over a power sweep while processing a test signal used for the target measurement or a representative signal; performing the target measurement during the power sweep, thereby determining a hardware contribution of the measurement system over the power sweep; and identifying the respective settings that lead to a minimum hardware contribution of the measurement system at various powers.

Abstract: A method for downlinking communication from a surface location to a bottom hole assembly during drilling operation is provided. The method includes pumping drilling fluid through a fluid line and through a drill string to the bottom hole assembly, and generating pressure wave signals by a modulator disposed against an outside surface of the fluid line at an outside-surface location of the fluid line. The modulator is disposed entirely outside of the fluid line. The method includes detecting and receiving at the bottom hole assembly the pressure wave signals generated by the modulator, and processing and decoding the pressure wave signals with a decoder associated with the bottom hole assembly to identify downlinking command purpose and required action for controlling drilling operations.

Abstract: The pharmaceutical industry is highly regulated to ensure the safety, efficacy, and quality of medicines and drug discolouration is one of the leading causes for drug recall. An object of the present invention is to provide an improved method of manufacturing cannabinoids for use in pharmaceuticals that is both stable and substantially pure. Such use of stable and substantially pure cannabinoids in pharmaceuticals will improve patient compliance to medication. The main steps of the method are decarboxylation, extraction, winterization and crystallisation.

Abstract: Methods, systems, and computer program products for gathering electronic signatures to be applied to collaboration system content objects (e.g., contracts, letters, insurance claims, riders, etc.). A collaboration system monitors changes made to the collaboration system content objects during electronic signature processing. A module of the content management system is configured to associate one or more instances of e-signing metadata to one or more of the stored content objects of the content management system. The e-signing metadata indicates whether or not a particular portion of the one or more of the stored content objects has been e-signed by a designated e-signatory. A collaborator who is not one of the designated e-signatories makes a change to one or more of the stored content objects (e.g., contracts, letters, insurance claims, riders, etc.). The change is remediated on-the-fly and the e-signing process continues without having to restart the e-signing process from the beginning.

Abstract: A method for downlinking communication from a surface location to a bottom hole assembly during drilling operation is provided. The method includes pumping drilling fluid through a fluid line and through a drill string to the bottom hole assembly, and generating pressure wave signals by a modulator disposed against an outside surface of the fluid line at an outside-surface location of the fluid line. The modulator is disposed entirely outside of the fluid line. The method includes detecting and receiving at the bottom hole assembly the pressure wave signals generated by the modulator, and processing and decoding the pressure wave signals with a decoder associated with the bottom hole assembly to identify downlinking command purpose and required action for controlling drilling operations.

Abstract: In methods and apparatuses that disclose a combination solar and wind electricity generating apparatus; an apparatus for the mounting and distribution of components, consisting of several or more sizes and shapes of connectors which allow tubes of scaling sizes to be connected at specific angles relative to each other, and which allow those components to be installed where the tubes terminate, substantially as and for the purpose set forth.

Abstract: A regulating device for regulating the steering angle of a vehicle includes a first controller unit having at least one integrating component and configured to receive a control difference between first steering angle information, which is deduced from nominal steering angle information, and an actual steering angle. The first controller unit provides actuation information for a motor operating the steering. A compensation control circuit superposed on the first controller unit is provided. The compensation control circuit has a feedback path receives actuation information of the motor, the output torque of the motor, and/or information dependent on the output torque of the motor as the input variable and, based on the input variable, provides steering angle compensation information.