Patents by Inventor Michael A. Spaid
Michael A. Spaid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040224325Abstract: Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of rare nucleic acids are provided.Type: ApplicationFiled: December 19, 2003Publication date: November 11, 2004Applicant: Caliper Life Sciences, Inc.Inventors: Michael R. Knapp, Jill M. Baker, Andrea W. Chow, Anne R. Kopf-Sill, Michael Spaid
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Publication number: 20040188254Abstract: Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated (and can be concentrated) by altering the applied pressure and electric fields in the various channel segments of the channel networks.Type: ApplicationFiled: December 22, 2003Publication date: September 30, 2004Applicant: Caliper Technologies Corp.Inventor: Michael Spaid
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Publication number: 20040123649Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: ApplicationFiled: December 5, 2003Publication date: July 1, 2004Applicant: Caliper Technologies Corp.Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
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Publication number: 20040053315Abstract: The present invention relates to novel methods and systems for determining the interaction of molecules using the phenomena of Taylor-Aris dispersion present in fluid flow in conduits. The method involves relating a change in dispersion of molecules to their level of interaction. The present invention also relates to an assay method using Taylor-Aris dispersion in a microfluidic system in order to examine molecular interactions in a variety of chemical and biochemical systems.Type: ApplicationFiled: August 4, 2003Publication date: March 18, 2004Applicant: Caliper Technologies Corp.Inventors: Michael Spaid, Jeffrey A. Wolk
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Patent number: 6681616Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: GrantFiled: November 9, 2001Date of Patent: January 27, 2004Assignee: Caliper Technologies Corp.Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
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Publication number: 20030230486Abstract: Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.Type: ApplicationFiled: March 4, 2003Publication date: December 18, 2003Applicant: Caliper Technologies Corp.Inventors: Ring-Ling Chien, J. Wallace Parce, Michael Spaid
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Publication number: 20030182991Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: ApplicationFiled: October 9, 2001Publication date: October 2, 2003Applicant: Caliper Technologies Corp.Inventors: Michael A. Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill
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Publication number: 20030103207Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: ApplicationFiled: December 13, 2002Publication date: June 5, 2003Applicant: Caliper Technologies Corp.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Peter C. Jann, Morten J. Jensen, Michael Spaid, Colin B. Kennedy, Michael J. Kennedy
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Patent number: 6547941Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: GrantFiled: July 31, 2001Date of Patent: April 15, 2003Assignee: Caliper Technologies Corp.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Peter C. Jann, Morten J. Jensen, Michael Spaid, Colin B. Kennedy, Michael J. Kennedy
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Publication number: 20030041652Abstract: Microfluidic devices, systems, and methods measure viscosity, flow times, and/or pressures. other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.Type: ApplicationFiled: July 26, 2002Publication date: March 6, 2003Applicant: Caliper Technologies Corp.Inventors: Michael Spaid, Andrea W. Chow, Benjamin N. Wang, Ring-Ling Chien, J. Wallace Parce, Anne R. Kopf-Sill, Josh Molho, Anubhav Tripathi, Matthew B. Kerby
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Publication number: 20030036206Abstract: Microfluidic devices and systems having enhanced detection sensitivity, particularly for use in non-fluorogenic detection methods, e.g., absorbance. The systems typically employ planar microfluidic devices that include one or more channel networks that are parallel to the major plane of the device, e.g., the predominant plane of the planar structure, and a detection channel segment that is substantially orthogonal to that plane. The detection system is directed along the length of the detection channel segment using a detection orientation that is consistent with conventional microfluidic systems.Type: ApplicationFiled: August 19, 2002Publication date: February 20, 2003Applicant: Caliper Technologies Corp.Inventors: Ring-Ling Chien, Jeffrey A. Wolk, Michael Spaid, Richard J. McReynolds
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Publication number: 20020180963Abstract: Microfluidic devices and systems having enhanced detection sensitivity, particularly for use in non-fluorogenic detection methods, e.g., absorbance. The systems typically employ planar microfluidic devices that include one or more channel networks that are parallel to the major plane of the device, e.g., the predominant plane of the planar structure, and a detection channel segment that is substantially orthogonal to that plane. The detection system is directed along the length of the detection channel segment using a detection orientation that is consistent with conventional microfluidic systems.Type: ApplicationFiled: February 14, 2002Publication date: December 5, 2002Applicant: Caliper Technologies Corp.Inventors: Ring-Ling Chien, Jeffrey A. Wolk, Michael Spaid, Richard J. McReynolds
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Publication number: 20020110926Abstract: Non-sipper microfluidic devices, e.g., planar devices that do not comprise an external capillary, are used to emulate or simulate the fluid flow profile of a device having an external capillary, e.g., a microfluidic sipper device. Samples are typically flowed through a sipper device, e.g., in sample plugs. To emulate fluid flow in a sipper device, emulator devices create sample plugs and flow them through the channels of a planar device.Type: ApplicationFiled: January 11, 2002Publication date: August 15, 2002Applicant: Caliper Technologies Corp.Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Michael Spaid, J. Wallace Parce
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Patent number: 6358387Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: GrantFiled: March 27, 2000Date of Patent: March 19, 2002Assignee: Caliper Technologies CorporationInventors: Anne R. Kopf-Sill, Andrea W. Chow, Peter C. Jann, Morten J. Jensen, Michael Spaid, Colin B. Kennedy, Michael J. Kennedy
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Publication number: 20010045358Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: ApplicationFiled: July 31, 2001Publication date: November 29, 2001Inventors: Anne R. Kopf-Sill, Andrea W. Chow, Peter C. Jann, Morten J. Jensen, Michael Spaid, Colin B. Kennedy, Michael Kennedy