Abstract: A method of modeling enhancer activity obtains a training dataset in electronic form. The dataset comprises a plurality of training enhancers and, for each such enhancer, a corresponding measured amount of activity of the enhancer in each of one or more states. Each enhancer is a tandem repeat. A model comprising a plurality of parameters is trained by inputting each training enhancer into the model. Upon input, the model applies the parameters to the training enhancer to generate, as model output, a corresponding predicted activity of the training enhancer for a first state of the one or more states. The plurality of parameters is refined based differentials between corresponding measured and predicted amounts of activity in the first state for each of the training enhancer. A plurality of test enhancers is generated using the trained model and their activity tested thereby modeling enhancer activity.

Abstract: Described herein are compositions comprising polynucleotides encoding for cell state specific transcription of a transgene. A polynucleotide may comprise a promoter that is engineered to promote cell state-specific transcription of a payload (e.g., a transgene). Also described herein are methods of treating, preventing, or ameliorating a disease or condition by delivering a polynucleotide to a cell of a subject and transcribing a transgene in a cell state-specific manner.

Abstract: A field terminal plug assembly including an RJ45 plug connected to a termination zone. The termination zone includes a wire cap, a rear sled, and an electrical board assembly with attached insulation displacement contacts (IDCs) electrically connected to the twisted wire-pairs of assembly cable. The wire cap is configured to terminate twisted wire-pairs of a communications cable to the IDCs when the wire cap is inserted into the rear sled. The IDCs contain at least a first and a second IDC, the first IDC having a first horizontal length and a first vertical length and the second IDC having a second horizontal length and a second vertical length. The first vertical length does not equal the second vertical length but the first vertical length plus the first horizontal length equals the second vertical length plus the second horizontal length.

Abstract: A field terminal plug assembly including an RJ45 plug connected to a termination zone. The termination zone includes a wire cap, a rear sled, and an electrical board assembly with attached insulation displacement contacts (IDCs) electrically connected to the twisted wire-pairs of assembly cable. The wire cap is configured to terminate twisted wire-pairs of a communications cable to the IDCs when the wire cap is inserted into the rear sled. The IDCs contain at least a first and a second IDC, the first IDC having a first horizontal length and a first vertical length and the second IDC having a second horizontal length and a second vertical length. The first vertical length does not equal the second vertical length but the first vertical length plus the first horizontal length equals the second vertical length plus the second horizontal length.

Abstract: A field terminal plug assembly including an RJ45 plug connected to a termination zone. The termination zone includes a wire cap, a rear sled, and an electrical board assembly with attached insulation displacement contacts (IDCs) electrically connected to the twisted wire-pairs of assembly cable. The wire cap is configured to terminate twisted wire-pairs of a communications cable to the IDCs when the wire cap is inserted into the rear sled. The IDCs contain at least a first and a second IDC, the first IDC having a first horizontal length and a first vertical length and the second IDC having a second horizontal length and a second vertical length. The first vertical length does not equal the second vertical length but the first vertical length plus the first horizontal length equals the second vertical length plus the second horizontal length.