Abstract: Provided herein are compositions, systems, kits, and methods for performing an activity based on detecting, in a sample from a cancer patient, the presence of elevated levels of Lactotransferrin (LTF) mRNA or protein, or detecting the presence in the MIF promoter region of at least one of: ?173C and ?794 CATT5-8, and treating a patient with immunotherapy, or generating a report that the subject should be treated with immunotherapy.

Abstract: Disclosed herein are compositions and methods for treating glioblastoma in a patient in need thereof by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a pharmaceutically acceptable salt thereof, and an immune checkpoint inhibitor.

Abstract: A catheter assembly comprises a catheter including a longitudinally extending wall with inner and outer surfaces. The inner surface of the wall defines a bore extending longitudinally through the catheter and at least partially defines a first lumen in the bore and a laterally adjacent second lumen in the bore. At least one of the first and second lumens communicates with an opening in the outer surface of the wall at a distal end of the catheter. An elongated separator includes a longitudinally extending surface that at least partially defines the second lumen. The longitudinally extending surface of the separator is disposed asymmetrically relative to the bore when viewed in cross-section taken transverse to the longitudinal extent of the separator adjacent to a distal end of the separator. At least a portion of the separator is movable relative to the bore and the inner surface of the catheter wall.

Abstract: A catheter assembly 10 comprises a catheter 12 including a longitudinally extending wall 16 with inner and outer surfaces. The inner surface of the wall defines a bore 22 extending longitudinally through the catheter defining a first lumen 52 and a second lumen 54. At least one of the first and second lumens communicates with an opening in the outer surface of the wall at a distal end of the catheter. An elongated separator 14 includes a longitudinally extending surface that at least partially defines the second lumen. The longitudinally extending surface of the separator is disposed asymmetrically relative to the bore when viewed in cross-section taken transverse to the longitudinal extent of the separator adjacent to a distal end of the separator. At least a portion of the separator is movable relative to the bore and the inner surface of the catheter wall.

Abstract: A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.

Abstract: A medical device and method to deliver a liquid solution to a patient's tissue. In particular a medical device that is an infusion device comprising a plurality of delivery tubes with varying lengths and internal diameters so that when the selected plurality of delivery tubes are implanted there is equal impedance to flow through each of the attached delivery tubes resulting in equal flow out of the delivery tubes to regions of interest in the patient's tissue. The plurality of delivery tubes may be attached to an infusion hub in a regular symmetrical pattern or an irregular asymmetrical pattern as required to deliver liquid solution to a plurality of regions of interest in the patient's tissue.

Abstract: A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.

Abstract: A catheter assembly 10 comprises a catheter 12 including a longitudinally extending wall 16 with inner and outer surfaces. The inner surface of the wall defines a bore 22 extending longitudinally through the catheter defining a first lumen 52 and a second lumen 54. At least one of the first and second lumens communicates with an opening in the outer surface of the wall at a distal end of the catheter. An elongated separator 14 includes a longitudinally extending surface that at least partially defines the second lumen. The longitudinally extending surface of the separator is disposed asymmetrically relative to the bore when viewed in cross-section taken transverse to the longitudinal extent of the separator adjacent to a distal end of the separator. At least a portion of the separator is movable relative to the bore and the inner surface of the catheter wall.

Abstract: A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.

Abstract: A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.

Abstract: A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.

Abstract: A convection enhanced delivery device comprises a support member and an elongated microcatheter carried by the support member. The microcatheter projects lengthwise away from the support member. The microcatheter includes a catheter lumen extending in a first direction. A fluid conduit carried by the support member. The fluid conduit includes a conduit lumen that extends in a second direction different than the first direction. The conduit lumen is in fluid communication with the catheter lumen. An inlet port and a connecting port are also carried by the support member. The inlet port is in fluid communication with the fluid conduit. The connecting port is separate from the inlet port and is in fluid communication with the fluid conduit. The connecting port is configured to engage an end portion of an external fluid conduit such that the external fluid conduit projects away from the connecting port and from the support member.

Abstract: A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter. A first portion of the wall of the first catheter is made of a relatively low durometer elastomeric material and is relatively extensible. A second portion of the wall is formed of a relatively high durometer elastomeric material and is relatively inextensible.

Abstract: A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter.

Abstract: A catheter assembly comprises a catheter having a wall at least partially defining a lumen. The lumen communicates with an opening in an exterior catheter surface at a distal end of the catheter. A lengthwise portion of the wall is made of a resilient material and is longitudinally extensible. The lengthwise portion of the wall has a diameter that is reduced when the lengthwise portion of the wall is longitudinally extended. The diameter of the lengthwise portion of the wall increases from a reduced condition when the lengthwise portion of the wall resiliently returns from a longitudinally extended condition.

Abstract: A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter. A first portion of the wall of the first catheter is made of a relatively low durometer elastomeric material and is relatively extensible. A second portion of the wall is formed of a relatively high durometer elastomeric material and is relatively inextensible.

Abstract: A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter.