Abstract: The present disclosure provides, in part, pyrazole carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

Abstract: An assembly for a papermaking machine includes: a seal strip with an upper surface configured to provide a seal for a suction roll; a seal strip holder, the seal strip residing in the seal strip holder and movable relative thereto; and a wear monitoring system. The wear monitoring system may include a magnet and magnetic field sensors or an ultrasonic transducer to monitor movement of the seal strip relative to the holder, thereby indicating wear.

Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.

Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.

Abstract: The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

Abstract: Systems and methods of an internet of things device connecting to a remote server. The internet of things device connects to a web target. The web target sends a response to the internet of things device indicating whether a change to the one or more settings of the internet of things device has been received at a cloud server. If a change has occurred, the internet of things device connects to a secure cloud server to update the settings on the internet of things device.

Abstract: A computer system may access an attributization rule and convert, based on the attributization rule, profile data into attributes for a robust recipient profile. The system may identify, based on tag logic, tags that are associated with the attributes. The tag logic may include instructions to compare the attributes with predetermined attributes associated with the tags. The system may map the identified tags to the recipient identifier. The system may perform communication with a mobile device based on the robust recipient profile and a real-time location of the mobile device. To perform the communication, the system may monitor the plurality of data channels for data comprising real-time location information for the mobile device. The system may determine the mobile device is proximate to a physical object that is associated with the tag and the system may transmit offer information to the mobile device.

Abstract: A portable exercise device that may be arranged in a number of different orientations and positions on the body of an individual. The portable exercise device includes a resistance assembly that enables a resistance of the portable exercise device to be adjusted.

Abstract: The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

Abstract: The invention provides methods for treating cancer in a patient comprising administering dosing regimens of (S,S)-(HO)2DEHSPM that unexpectedly reverse or reduce the onset of severe liver toxicity and improve patient safety profiles.

Abstract: The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

Abstract: A hybrid three-layer system is presented. The hybrid three-layer system includes a two-layer composite system and an additively manufactured third layer comprising a lattice structure. The composite layer system includes a metallic substrate, a structured surface, and a thermal protection system. The structured surface may be additively manufactured onto the metallic substrate and includes structured surface features formed to project above the metallic substrate. Each of the structured surface features are separated from adjacent structured surface features by grooves. The thermal protection coating may be thermally sprayed onto the structured surface and is bonded to each of the structured surface features. The lattice structure is in contact with a surface of the metallic substrate of the composite layer system.

Abstract: This disclosure provides systems and methods for charging a vehicle. A vehicle and charging station can be designed such that an electric or hybrid vehicle can operate in a fashion similar to a conventional vehicle by being opportunity charged throughout a known route.

Abstract: Systems and methods for charging an electric bus having a charging interface on its roof may include determining that an approaching bus is supposed to be charged at the charging station, lowering the charging head of the charging station to land on the roof of the bus, and moving the bus with the charge head on its roof to engage the charging head with the charging interface.

Abstract: A vacuum nozzle includes a main body and at least one auxiliary body. The main body has a first open end and a second open end. The first open end is coupleable to a vacuum hose and the second open end is configured for receiving materials to be transferred. The auxiliary body has a first auxiliary opening and a second auxiliary opening. The first auxiliary opening is positioned closer to the first open end of the main body than the second open end of the main body. The second auxiliary opening covers a portion of the second open end of the main body. The auxiliary body provides a dedicated auxiliary passageway for providing a consistent flow of air to the second open end of the main body when the vacuum nozzle is in use.

Abstract: A low-floor electric bus includes a plurality of battery packs mounted under the floor of such that the floor inside the bus between a front axle and a rear axle of the bus is substantially flat. Each battery pack may include an enclosure and multiple battery modules positioned within the enclosure. And, each battery module may include a plurality of battery cells electrically connected together.

Abstract: This disclosure provides systems and methods for charging a vehicle. A vehicle and charging station can be designed such that an electric or hybrid vehicle can operate in a fashion similar to a conventional vehicle by being opportunity charged throughout a known route.

Abstract: An assembly for a papermaking machine includes: a seal strip with an upper surface configured to provide a seal for a suction roll; a seal strip holder, the seal strip residing in the seal strip holder and movable relative thereto; and a wear monitoring system. The wear monitoring system may include a magnet and magnetic field sensors or an ultrasonic transducer to monitor movement of the seal strip relative to the holder, thereby indicating wear.

Abstract: A method of etching a silicon oxide film with high precision at high selectivity as compared with a silicon nitride film while establishing both of a higher etching rate of the silicon oxide film and a lower etching rate of the silicon nitride film is provided. An etching method according to the present invention is directed to a dry etching method for etching a film structure without using plasma in which an end of a film layer having a silicon oxide film vertically sandwiched between silicon nitride films and laminated and formed in advance on a wafer disposed in a processing chamber forms a side wall of a groove or a hole while a processing gas is supplied into the processing chamber, the method including the steps of: supplying a hydrogen fluoride gas; cooling the wafer to a low temperature of ?30° C. or lower, preferably, to ?30 to ?60° C.; and etching the silicon oxide film laterally from the end.