Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.

Abstract: Computer system, method and program product for identifying a malicious intrusion. A first number of different destination IP addresses, a second number of different destination ports and a third number of different signatures of messages, are identified from a source IP address during a predetermined period. A determination is made that in one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures. Based on the determination that in the one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures, a determination is made that the messages are characteristic of a malicious intrusion.

Abstract: This invention relates to a method and system for producing electrical current based on a temperature differential. The system comprises of at least one unit having a plurality of chips sandwiched between a higher temperature layer on one side and a lower temperature layer on an opposite side. Chips are preferably thermoelectric solid state chips that produce an electric current when there is a temperature differential created across the chips. There are a plurality of chips in each unit and the chips within each unit are electrically connected to one another in series. Preferably, there are a plurality of units.

Abstract: Computer system, method and program product for identifying a malicious intrusion. A first number of different destination IP addresses, a second number of different destination ports and a third number of different signatures of messages, are identified from a source IP address during a predetermined period. A determination is made that in one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures. Based on the determination that in the one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures, a determination is made that the messages are characteristic of a malicious intrusion.

Abstract: A computer system and program product for automatically determining if a packet is a new, exploit candidate. First program instructions determine if the packet is a known exploit or portion thereof. Second program instructions determine if the packet is network broadcast traffic presumed to be harmless. Third program instructions determine if the packet is network administration traffic. If the packet is a known exploit or portion thereof, network broadcast traffic, or network administration traffic, the packet is not considered a new, exploit candidate. If the packet is not a known exploit or portion thereof, network broadcast traffic, or network administration traffic, the packet is an exploit candidate. Alternately, the first program instructions determine if the packet is a known exploit or portion thereof. The second program instructions determine if the packet is network broadcast traffic presumed to be harmless.

Abstract: A method of progressive response for invoking and suspending blocking measures that defend against network anomalies such as malicious network traffic so that false positives and false negatives are minimized. When an anomaly is detected, the detector notifies protective equipment such as a firewall or a router to invoke a blocking measure. The blocking measure is maintained for an initial duration, after which it is suspended while another test for the anomaly is made. If the anomaly is no longer evident, the method returns to the state of readiness. Otherwise, a loop is executed to re-apply the blocking measure for a specified duration, then suspend the blocking measure and test again for the anomaly. If the anomaly is detected, the blocking measure is re-applied, and its duration is adapted. If the anomaly is no longer detected, the method returns to the state of readiness.

Abstract: A method of progressive response for invoking and suspending blocking measures that defend against network anomalies such as malicious network traffic so that false positives and false negatives are minimized. When an anomaly is detected, the detector notifies protective equipment such as a firewall or a router to invoke a blocking measure. The blocking measure is maintained for an initial duration, after which it is suspended while another test for the anomaly is made. If the anomaly is no longer evident, the method returns to the state of readiness. Otherwise, a loop is executed to re-applying the blocking measure for a specified duration, then suspend the blocking measure and test again for the anomaly. If the anomaly is detected, the blocking measure is re-applied, and its duration is adapted. If the anomaly is no longer detected, the method returns to the state of readiness.

Abstract: A method of progressive response for invoking and suspending blocking measures that defend against network anomalies such as malicious network traffic so that false positives and false negatives are minimized. When an anomaly is detected, the detector notifies protective equipment such as a firewall or a router to invoke a blocking measure. The blocking measure is maintained for an initial duration, after which it is suspended while another test for the anomaly is made. If the anomaly is no longer evident, the method returns to the state of readiness. Otherwise, a loop is executed to re-applying the blocking measure for a specified duration, then suspend the blocking measure and test again for the anomaly. If the anomaly is detected, the blocking measure is re-applied, and its duration is adapted. If the anomaly is no longer detected, the method returns to the state of readiness.

Abstract: The present invention provides compounds and methods of synthesizing furanose and aminofuranose compounds of Formula I which are useful fro treating rheumatoid arthritis, immunomodulatory diseases and disorders, inflammation, and diseases and disorders characterized by exhibiting tissue proliferation.

Abstract: The invention features novel mutations in the FREAC3 gene. Our discovery provides methods for early diagnosis of glaucoma, other disorders of the eye, and heart defects. Also provided are cells having at least one deficient FREAC3 gene. Such cells may be used to detect therapeutic compounds that mimic FREAC3, are agonists of FREAC3, or otherwise modulate the level of FREAC3 biological activity.

Abstract: The present invention provides compounds and methods of synthesizing furanose and aminofuranose compounds of Formula I 1

Abstract: A process for fabricating a printed circuit board includes the steps of producing data in a printing-scan format representative of a designed area circuit pattern; with such data, printing a mask pattern, corresponding to said circuit pattern, on the metal surface of a dielectric substrate; and etching to remove unmasked portions of the metal layer.

Abstract: An improved nest device construction for use with insertable ink jet print/cartridges having detent portions accurately located vis a vis their orifice array. The construction includes a U-shaped member, having a handle and arms spaced to receive a print/cartridge, which is mounted on a printer carriage for rotation between insert and retain positions. The arms have interior pinch surfaces for slidably engaging an inserted print/cartridge during rotation of said member and a bottom lip edge that extends inwardly to initially support a print/cartridge in an insert position. A spring is located between the arms of the member to contact the bottom rear surface of an inserted print/cartridge and tilt its front face into engagement with a positioning knife edge.

Abstract: An ink cartridge interface system for multicolor ink jet printing apparatus of the kind having discrete, different color, continuous ink jet circulation subsystems. Each cartridge has a key system component, formed on one of its wall elements at a location for interfitting with a printer housing key system component, and is constructed to have a shape that uniquely identifies the color of ink within said ink cartridge. The printer has a plurality of separate housings each with a different key system component designed to interfit with its particular ink color cartridge.