Patents by Inventor Michael A. Walters

Michael A. Walters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12209140
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: January 28, 2025
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Publication number: 20230101009
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Application
    Filed: November 21, 2022
    Publication date: March 30, 2023
    Applicants: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Patent number: 11505572
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: November 22, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Patent number: 10981951
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: April 20, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Publication number: 20210040148
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Application
    Filed: October 22, 2020
    Publication date: February 11, 2021
    Applicants: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Publication number: 20170002040
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Application
    Filed: January 30, 2015
    Publication date: January 5, 2017
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Patent number: 8931099
    Abstract: Computer system, method and program product for identifying a malicious intrusion. A first number of different destination IP addresses, a second number of different destination ports and a third number of different signatures of messages, are identified from a source IP address during a predetermined period. A determination is made that in one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures. Based on the determination that in the one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures, a determination is made that the messages are characteristic of a malicious intrusion.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: January 6, 2015
    Assignee: International Business Machines Corporation
    Inventors: Jeffrey S. Lahann, Frederic G. Thiele, Michael A. Walter
  • Publication number: 20140048111
    Abstract: This invention relates to a method and system for producing electrical current based on a temperature differential. The system comprises of at least one unit having a plurality of chips sandwiched between a higher temperature layer on one side and a lower temperature layer on an opposite side. Chips are preferably thermoelectric solid state chips that produce an electric current when there is a temperature differential created across the chips. There are a plurality of chips in each unit and the chips within each unit are electrically connected to one another in series. Preferably, there are a plurality of units.
    Type: Application
    Filed: August 17, 2012
    Publication date: February 20, 2014
    Inventors: THOMAS G. HINSPERGER, Michael A. Walter
  • Publication number: 20130333036
    Abstract: Computer system, method and program product for identifying a malicious intrusion. A first number of different destination IP addresses, a second number of different destination ports and a third number of different signatures of messages, are identified from a source IP address during a predetermined period. A determination is made that in one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures. Based on the determination that in the one or more other such predetermined periods the source IP address sent messages having the first number of different destination IP addresses, the second number of different destination ports and the third number of different signatures, a determination is made that the messages are characteristic of a malicious intrusion.
    Type: Application
    Filed: August 13, 2013
    Publication date: December 12, 2013
    Applicant: International Business Machines Corporation
    Inventors: JEFFREY S. LAHANN, FREDERIC G. THIELE, MICHAEL A. WALTER
  • Patent number: 8127356
    Abstract: A computer system and program product for automatically determining if a packet is a new, exploit candidate. First program instructions determine if the packet is a known exploit or portion thereof. Second program instructions determine if the packet is network broadcast traffic presumed to be harmless. Third program instructions determine if the packet is network administration traffic. If the packet is a known exploit or portion thereof, network broadcast traffic, or network administration traffic, the packet is not considered a new, exploit candidate. If the packet is not a known exploit or portion thereof, network broadcast traffic, or network administration traffic, the packet is an exploit candidate. Alternately, the first program instructions determine if the packet is a known exploit or portion thereof. The second program instructions determine if the packet is network broadcast traffic presumed to be harmless.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: February 28, 2012
    Assignee: International Business Machines Corporation
    Inventors: Frederic G. Thiele, Michael A. Walter
  • Patent number: 7707633
    Abstract: A method of progressive response for invoking and suspending blocking measures that defend against network anomalies such as malicious network traffic so that false positives and false negatives are minimized. When an anomaly is detected, the detector notifies protective equipment such as a firewall or a router to invoke a blocking measure. The blocking measure is maintained for an initial duration, after which it is suspended while another test for the anomaly is made. If the anomaly is no longer evident, the method returns to the state of readiness. Otherwise, a loop is executed to re-apply the blocking measure for a specified duration, then suspend the blocking measure and test again for the anomaly. If the anomaly is detected, the blocking measure is re-applied, and its duration is adapted. If the anomaly is no longer detected, the method returns to the state of readiness.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: April 27, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert William Danford, Kenneth M. Farmer, Clark Debs Jeffries, Robert B. Sisk, Michael A. Walter
  • Patent number: 7308716
    Abstract: A method of progressive response for invoking and suspending blocking measures that defend against network anomalies such as malicious network traffic so that false positives and false negatives are minimized. When an anomaly is detected, the detector notifies protective equipment such as a firewall or a router to invoke a blocking measure. The blocking measure is maintained for an initial duration, after which it is suspended while another test for the anomaly is made. If the anomaly is no longer evident, the method returns to the state of readiness. Otherwise, a loop is executed to re-applying the blocking measure for a specified duration, then suspend the blocking measure and test again for the anomaly. If the anomaly is detected, the blocking measure is re-applied, and its duration is adapted. If the anomaly is no longer detected, the method returns to the state of readiness.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: December 11, 2007
    Assignee: International Business Machines Corporation
    Inventors: Robert William Danford, Kenneth M. Farmer, Clark Debs Jeffries, Robert B. Sisk, Michael A. Walter
  • Publication number: 20040236963
    Abstract: A method of progressive response for invoking and suspending blocking measures that defend against network anomalies such as malicious network traffic so that false positives and false negatives are minimized. When an anomaly is detected, the detector notifies protective equipment such as a firewall or a router to invoke a blocking measure. The blocking measure is maintained for an initial duration, after which it is suspended while another test for the anomaly is made. If the anomaly is no longer evident, the method returns to the state of readiness. Otherwise, a loop is executed to re-applying the blocking measure for a specified duration, then suspend the blocking measure and test again for the anomaly. If the anomaly is detected, the blocking measure is re-applied, and its duration is adapted. If the anomaly is no longer detected, the method returns to the state of readiness.
    Type: Application
    Filed: May 20, 2003
    Publication date: November 25, 2004
    Applicant: International Business Machines Corporation
    Inventors: Robert William Danford, Kenneth M. Farmer, Clark Debs Jeffries, Robert B. Sisk, Michael A. Walter
  • Patent number: 6794497
    Abstract: The present invention provides compounds and methods of synthesizing furanose and aminofuranose compounds of Formula I which are useful fro treating rheumatoid arthritis, immunomodulatory diseases and disorders, inflammation, and diseases and disorders characterized by exhibiting tissue proliferation.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: September 21, 2004
    Assignee: Warner-Lambert Company
    Inventors: Armen M. Boldi, Elaine B. Krueger, Michael A. Walters, Thutam P. Hopkins, Meghan T. Keaney
  • Publication number: 20030013087
    Abstract: The invention features novel mutations in the FREAC3 gene. Our discovery provides methods for early diagnosis of glaucoma, other disorders of the eye, and heart defects. Also provided are cells having at least one deficient FREAC3 gene. Such cells may be used to detect therapeutic compounds that mimic FREAC3, are agonists of FREAC3, or otherwise modulate the level of FREAC3 biological activity.
    Type: Application
    Filed: April 16, 1999
    Publication date: January 16, 2003
    Inventors: MICHAEL A. WALTER, TIM JORDAN, VINCENT RAYMOND
  • Publication number: 20020173632
    Abstract: The present invention provides compounds and methods of synthesizing furanose and aminofuranose compounds of Formula I 1
    Type: Application
    Filed: January 22, 2002
    Publication date: November 21, 2002
    Inventors: Armen M. Boldi, Elaine B. Krueger, Michael A. Walters, Thutam P. Hopkins, Meghan T. Keaney
  • Patent number: 4991287
    Abstract: A process for fabricating a printed circuit board includes the steps of producing data in a printing-scan format representative of a designed area circuit pattern; with such data, printing a mask pattern, corresponding to said circuit pattern, on the metal surface of a dielectric substrate; and etching to remove unmasked portions of the metal layer.
    Type: Grant
    Filed: December 26, 1989
    Date of Patent: February 12, 1991
    Assignee: Eastman Kodak Company
    Inventors: Michael J. Piatt, Mark E. Brown, Michael A. Walters
  • Patent number: 4990938
    Abstract: An improved nest device construction for use with insertable ink jet print/cartridges having detent portions accurately located vis a vis their orifice array. The construction includes a U-shaped member, having a handle and arms spaced to receive a print/cartridge, which is mounted on a printer carriage for rotation between insert and retain positions. The arms have interior pinch surfaces for slidably engaging an inserted print/cartridge during rotation of said member and a bottom lip edge that extends inwardly to initially support a print/cartridge in an insert position. A spring is located between the arms of the member to contact the bottom rear surface of an inserted print/cartridge and tilt its front face into engagement with a positioning knife edge.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: February 5, 1991
    Assignee: Eastman Kodak Company
    Inventors: John M. Brandon, Richard J. Ratermann, Michael A. Walters, David P. Schenck
  • Patent number: 4853708
    Abstract: An ink cartridge interface system for multicolor ink jet printing apparatus of the kind having discrete, different color, continuous ink jet circulation subsystems. Each cartridge has a key system component, formed on one of its wall elements at a location for interfitting with a printer housing key system component, and is constructed to have a shape that uniquely identifies the color of ink within said ink cartridge. The printer has a plurality of separate housings each with a different key system component designed to interfit with its particular ink color cartridge.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: August 1, 1989
    Assignee: Eastman Kodak Company
    Inventor: Michael A. Walters
  • Patent number: D299346
    Type: Grant
    Filed: April 24, 1986
    Date of Patent: January 10, 1989
    Assignee: Eastman Kodak Company
    Inventors: David A. Lehman, Michael A. Walters