Abstract: Nucleic acids are described that encode for triggering receptor expressed on myeloid cells 2 (TREM2) and that can be used in expression constructs, vectors and gene therapies. Also described are methods of using the same for the treatment of TREM2-associated diseases and disorders, especially neurological diseases such as Alzheimer's Disease (AD), Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) or Nasu-Hakola Disease (NHD).

Abstract: Weather metrics data and a weather factor relationship knowledgebase are received and used to forecast the weather-based demand. The weather factor relationship knowledgebase can be a weather-impact model. The weather-impact model can comprise at least one of an empirical scoring matrix, a weather indices template, and a proxy model conditions template. The weather-impact model can be derived from an analysis of normalized proxy sales history data. Optionally, the weather-based demand can be scaled, deaggregated, or both.

Abstract: Systems and methods to generate business recommendations for specific business actions based on weather element forecasts and known relationships between a business activity and weather elements are provided. The system includes a confidence level filter, an opportunity matrix filter, a weather decision point generator, a business rule recommendation engine and a business rule knowledge database. Methods to generate a business recommendation for a business activity are also provided. The methods include receiving weather driven demand data, assigning opportunity measures to each of the data points, identifying weather decision points based on opportunity measures, and applying business weather rules to the weather decision points to generate business recommendations. In a further feature, a weather element relationship and/or a weather element forecast confidence level is assigned to each data point within the weather driven demand data.

Abstract: Systems and methods to generate business recommendations for specific business actions based on weather element forecasts and known relationships between a business activity and weather elements are provided. The system includes a confidence level filter, an opportunity matrix filter, a weather decision point generator, a business rule recommendation engine and a business rule knowledge database. Methods to generate a business recommendation for a business activity are also provided. The methods include receiving weather driven demand data, assigning opportunity measures to each of the data points, identifying weather decision points based on opportunity measures, and applying business weather rules to the weather decision points to generate business recommendations. In a further feature, a weather element relationship and/or a weather element forecast confidence level is assigned to each data point within the weather driven demand data.

Abstract: Weather metrics data and a weather factor relationship knowledgebase are received and used to forecast the weather-based demand. The weather factor relationship knowledgebase can be a weather-impact model. The weather-impact model can comprise at least one of an empirical scoring matrix, a weather indices template, and a proxy model conditions template. The weather-impact model can be derived from an analysis of normalized proxy sales history data. Optionally, the weather-based demand can be scaled, deaggregated, or both.