Abstract: The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided.

Abstract: A method of measuring the state or condition of spatially spaced apart machine parts subject to wear and emitting an acoustic signature.

Abstract: Disclosed herein are genetically engineered hematopoietic cells, which express one or more Krebs cycle modulating polypeptides, and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide or a chimeric antigen receptor (CAR) polypeptide) capable of binding to a target antigen of interest. Also disclosed herein are uses of the engineered hematopoietic cells for inhibiting cells expressing a target antigen in a subject in need thereof.

Abstract: Herein is disclosed a rim for a wheel. the rim comprising a barrel having first and second flanges extending radially outward from opposing edges of the barrel. and the barrel comprising a first bead seat and a second bead seat arranged axially inwardly. respectively. of the first and second flanges, wherein the barrel, and first and second flanges. comprise layers of structural fibres bound in a polymer matrix, wherein a pre-form insert is disposed between layers of the structural fibres. wherein the insert comprises a material which acts to absorb and/or deflect and/or dissipate energy from a load or impact applied axially and/or radially to a rim and/or acts to increase the hoop stiffness of the wheel and wherein the insert has, when viewed in cross-section (with the axis of the rim being parallel to the plane of the cross-section). two elongate portions. with a first elongate portion of the insert extending into one of the first or second flanges.

Abstract: A method of identifying a vehicle total loss claim includes retrieving a plurality of historical vehicle records, labeling the records as repaired or total loss, calculating mean cost values, training a regression model, optimizing a probability threshold, analyzing a plurality of inputs to generate a prediction, and transmitting the prediction. A computing system includes a transceiver; a processor; and a memory storing instructions that, when executed by the processor, cause the computing system to receive answers, transmit the answers, receive a prediction, when the prediction is repairable, generate a repair suggestion, and when the prediction is total loss, generate a settlement offer. A non-transitory computer readable medium containing program instructions that when executed, cause a computer to receive answers, transmit the answers, receive a prediction, when the prediction is repairable, generate a repair suggestion, and when prediction is total loss, generate a settlement offer.

Abstract: Aspects of the present invention provide a corn protein isolate, comprising at least about 85 wt % corn protein on a dry basis; an “a*” color value ranging from about ?0.5 and 1.5, and a “b” color value ranging from about 10 and 25; and less than about 1.5% oil on a dry basis. Further aspects include methods of making the same.

Abstract: Systems and methods for permitting DOCSIS 3.1 equipment to operate at higher frequencies than specified in the DOCSIS 3.1 standard. Exemplary systems may be capable of alternating between a first mode of operation that provides DOCSIS 3.1 compatible services and a second mode of operation providing a higher level of service than DOCSIS 3.1.

Abstract: The present application provides BCMA targeting chimeric antigen receptor (CAR) comprising a BCMA binding region and an intracellular costimulatory domain derived from DAP10. Further provided are engineered immune effector cells (such as NK cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Abstract: A headstone socket preserver for insertion in the ground adjacent to a burial site. The headstone socket preserver has a body comprising a top surface, a bottom surface spaced from the top surface along a first axis, and at least one peripheral surface extending between the top surface and the bottom surface. The body can have a decreasing width dimension, measured along a second axis that is perpendicular to the first axis, between the top surface and the bottom surface.

Abstract: Systems and methods for manufacturing a garment, include: receiving garment design input data for a garment design including data representing a first textile structural unit at a first location and data representing a second textile structural unit at a second location; generating a textile production machine instruction data set based on the garment design input data; forming a first garment using a first textile production machine to include the first textile structural unit and the second textile structural unit; creating revised garment design input data for the garment design based on the first garment based on receiving additional body map data relating to the first garment; generating revised textile production machine instruction data set based on the revised garment design input data; and forming a second garment using a textile production machine and the revised garment design input data including the changes to the garment design.

Abstract: The present application relates to halo-substituted heterocyclic compounds of Formula (I): or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting HPK1, such as cancer.

Abstract: Robotic intervention systems may be used to perform medical procedures on patients using percutaneous instruments. Percutaneous interventional techniques are typically short in duration, requiring quick set-up and tear down to ensure minimal impact to medical workflow or process while maintaining a sterile field. A sterile disposable interface provides an inexpensive sterile barrier between the interventional site and the robotic system.

Abstract: A matching computer system for electronically generating, matching, and providing online user profiles, and determining a sharing score between the online user profiles is provided. The matching computer system may be configured to generate online user profiles associated with users of the systems. The matching computer system may be also configured to calculate a base score based upon the generated online user profile. Each base score represents a level of trustworthiness of each respective user. The matching computer system may be further configured to determine a sharing score between users based upon the base scores. Each sharing score represents a level of matching between the online user profiles.

Abstract: A head unit system for controlling motion of an object includes a secondary object sensor and a head unit that includes shear thickening fluid (STF) and a chamber configured to contain the STF. The chamber further includes a front channel and a back channel. The head unit further includes a piston housed at least partially radially within the piston compartment and separating the back channel and the front channel. The piston includes a first piston bypass and a second piston bypass to control flow of the STF between opposite sides of the piston. The chamber further includes a set of fluid flow sensors and a set of fluid manipulation emitters to control the flow of the STF to cause selection of one of a variety of shear rates for the STF within the chamber to control motion of the object with regards to a secondary object.

Abstract: Systems and methods disclosed herein relates generally to using virtual reality (VR) for creating a digital twin of a home. In some embodiments, image data of a structure and an indication of a modification may be received, a virtual reality (VR) feed including a virtual representation of the modification proximate the structure may be generated, and the VR feed may be provided for presentation to a user within a VR display.

Abstract: A head unit system for controlling motion of an object includes an environment sensor and a head unit that include shear thickening fluid (STF) and a chamber to contain the STF. The chamber further includes front and back channels. The head unit further includes a piston housed radially within the piston compartment and separating the back channel and the front channel. The piston includes a first piston bypass and a second piston bypass to control flow of the STF between opposite sides of the piston. The chamber further includes a set of fluid flow sensors and a set of fluid manipulation emitters to control the flow of the STF to cause selection of one of a variety of shear rates for the STF within the chamber to abate an internal factor of concern associated with an internal environment as sensed by the environment sensor.

Abstract: Implementations set forth herein relate to an automated assistant and/or other application that can adapt settings of a foldable display interface of a computing device according to user interactions occurring during a multilingual conversation. During the multilingual conversation between at least two users, translated content of the conversation can be rendered at a portion of the display interface according to which user is actively speaking. When a user is actively speaking, a brightness level of a portion of the display interface that is facing another user in the conversation can be modified to emphasize that the user is speaking and that the translated content is being rendered. When the user who is speaking is also the owner of the computing device, a portion of the display interface that is facing the other user can exhibit a limited responsiveness to touch inputs.