Abstract: The present disclosure provides an automated sample analyzer having a continuous scanning optical assembly for performing an assay. The optical assembly allows for robust detection of light emitted from a reaction mixture in a dynamically changing environment, such as detection of light from a reaction mixture that is being rotated about an axis at high rotational velocity.

Abstract: A deployment system is provided. The deployment system includes an expandable stent prosthesis. The expandable stent prothesis includes a trunk portion, a first branching portion attached to the trunk portion, and a second branching portion attached to the trunk portion. The first branching portion is configured to secure the second branching portion when the expanded stent prosthesis is in a collapsed configuration.

Abstract: A deployment system is provided. The deployment system includes an expandable stent prosthesis and a medical wire extending through the stent prosthesis. A longitudinal end of the medical wire extends out of a longitudinal end of the stent prosthesis. A protective portion is disposed between the longitudinal end of the stent prosthesis and the longitudinal end of the medical wire. A diameter of the protective portion exceeds a diameter of the longitudinal end of the stent prosthesis when the stent prosthesis is in a collapsed configuration.

Abstract: A method of manipulating a deployment system is provided. The method includes, delivering a deployment system to a branching implant site. The deployment system includes an expandable stent prosthesis including a trunk portion, a first branching portion, and a second branching portion. The deployment system also includes a floss wire including a proximal portion disposed in the first branching portion, a bend disposed at a bifurcation point of the stent prosthesis, and a distal portion disposed in the second branching portion. The method further includes displacing the floss wire to seat the expandable stent prosthesis within the branching implant site, and expanding the expandable stent prosthesis within the branching implant site.

Abstract: A method of manipulating a deployment device is provided. The method includes delivering a deployment system including an expandable branching stent prosthesis to a branching implant site including a trunk, a first branch, and a second branch. The branching stent prosthesis includes a trunk portion, a first branching portion, and a second branching portion. The method further includes advancing a sheath over the second branching portion, seating the stent prosthesis at the branching implant, and withdrawing the sheath from over the second branching portion.

Abstract: The present invention relates to a compound of formula (I), pharmaceutically acceptable salts thereof as well as pharmaceutical compositions comprising the same and, in particular, the compounds of formula (I) and pharmaceutical compositions for use in a method of topical treatment of a skin cancer of a mammal, wherein said method comprises topical administration of said compound to said mammal.

Abstract: A modular cosmetic container assembly includes a base having a bottom wall and a plurality of sidewalls defining an insert receiving space, and a plurality of inserts removably insertable into the insert receiving space. Each of the inserts has a same plurality of outer dimensions and at least one well. The inserts differ in a number of the wells in each of the inserts. The insert receiving space is sized to receive at least two of the plurality of inserts that are all interchangeably positionable in the insert receiving space.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning electrochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: A loaded-chamber indicator firearm trigger device is provided. The device is comprised of a firearm with a trigger (or only a trigger in one embodiment), wherein the trigger is comprised of an exterior side surface with at least one indicia. The indicia is only visible outside of the frame of the firearm when the firing pin of the firearm is engaged (which causes the portion of the trigger the indicia is positioned on to move outside of the frame of the firearm). As a result, the observability of the indicia on the trigger indicates the firearm has an engaged firing pin and is ready to fire.

Abstract: A reinforcing system for a vessel that can contain water. The system includes a shell for containing water, the shell having one or more jets extending therethrough from an inside of the shell to an outside of the shell, and a structural support layer on an underside of the shell. The structural support layer can include: an inner layer of rigidizer applied to the underside of the shell, a central low density core, and an outer layer of rigidizer applied to the central low-density core. The structural support layer can extend from a bottom side of the underside of the shell, across at least one sidewall of the underside of the shell, and form at least one rib along the sidewall of the underside of the shell.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: A vascular prosthesis deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include a pliant member, wherein the pliant member is configured receive a vascular prosthesis. The pliant member may also be configured to aid in incrementally deploying a vascular prosthesis.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: A loaded-chamber indicator firearm trigger device is provided. The device is comprised of a firearm with a trigger (or only a trigger in one embodiment), wherein the trigger is comprised of an exterior side surface with at least one indicia. The indicia is only visible outside of the frame of the firearm when the firing pin of the firearm is engaged (which causes the portion of the trigger the indicia is positioned on to move outside of the frame of the firearm). As a result, the observability of the indicia on the trigger indicates the firearm has an engaged firing pin and is ready to fire.

Abstract: Expandable branching stent prostheses and methods of deployment for the same are discussed herein. A deployment system includes an expandable branching stent prosthesis having a trunk portion, a first branching portion, and a second branching portion. The deployment system also includes a first balloon disposed within the first branching portion and the trunk portion, the first balloon being configured to inflate to deploy the first branching portion and the trunk portion of the expandable branching stent prosthesis. The deployment system also includes a second balloon disposed within the second branching portion and configured to inflate to deploy the second branching portion of the expandable branching stent prosthesis.

Abstract: A water delivery pipe made from PVC or PVCO and having an inner surface which is rifled. The inner surface of the pipe preferably includes a graphene material. The pipe has improved anti-bacterial properties such that the formation of bacterial biofilms is eliminated or reduced. Methods of making the pipe are also disclosed.

Abstract: A modular cosmetic container assembly includes a base having a bottom wall and a plurality of sidewalls defining an insert receiving space, and a plurality of inserts removably insertable into the insert receiving space. Each of the inserts has a same plurality of outer dimensions and at least one well. The inserts differ in a number of the wells in each of the inserts. The insert receiving space is sized to receive at least two of the plurality of inserts that are all interchangeably positionable in the insert receiving space.

Abstract: Dual-wire lumen systems and methods of deployment for the same are discussed herein. Methods for deployment of dual-wire lumen systems include inserting a dilator system through a first branching portion of a branching stent prosthesis which includes the first and a second branching portions and a trunk portion. The dilator system includes a dilator and a first guidewire. The method further includes directing the dilator system towards an intersection between the first branching portion, the second branching portion, and the trunk portion of the branching stent prosthesis and advancing a distal end of the dilator toward the second branching portion. The method further includes advancing, at the intersection, a distal end of the first guidewire along the trunk portion through a port located on a sidewall of the dilator. The method further includes retracting the dilator through the first branching portion.

Abstract: A vascular prosthesis deployment device and related methods are disclosed. In some embodiments the deployment device may include a delivery catheter assembly. The delivery catheter assembly may include an outer sheath, an intermediate sheath, and an inner sheath. One or more of the outer sheath, the intermediate sheath, and the inner sheath may be reinforced with a braided structure to prevent elongation and ovalization of the sheaths. The braided structure may include one or more yarn members imbedded in a material and formed from a plurality of twisted singles. The twisted singles may be formed from an aromatic polyamide material.

Abstract: An organoleptically pleasing snack food chip that contains a low amount of carbohydrates, a good source of protein, and delivers a crunchy texture includes from about 15% to about 35% of almond flour; from about 20% to about 40% of a source of protein; from about 1% to about 5% of a starch; from about 0.1% to about 2% of a leavening agent; from about 20% to about 55% of oil; and has a moisture content between about 0.1% and about 3%. The almond flour may include a mixture of different types of almond flour. The source of protein may include one or more of one or more milk proteins, one or more plant proteins, and one or more seed proteins.