Abstract: The invention relates to a head cap, for placement of a head of a person. The head cap comprises a support shell with an inner face facing the head and an outer face facing away from the head and a cover shell with an inner face facing the head and a outer face facing away from the head, wherein at least the inner face of the support shell is optionally at least along an outer edge of the inner face, preferably over the entire surface, cushioned with a cushion layer and is covered by a flexible cover layer which encloses the inner face and extends up to the outer face of the support shell at least in a peripheral support shell edge region, wherein at least one cover layer edge is covered by the cover shell.

Abstract: Systems and methods provide witness sled hardware installed in a chassis and supported during network failures using management resources of the chassis. A chassis may include data storage devices and Information Handling Systems (IHSs), each configured to store data redundantly to the data storage devices, such as part of a vSAN (Virtual Storage Area Network). The witness sled is configured to provide witness functions, such as to arbitrate discrepancies in the redundantly stored data. The chassis also includes a chassis management controller (CMC) configured to initiate a connection with the witness sled via a management signaling pathway in response to a notification indicating a network fault in a high-speed connection used by the IHSs in communicating with the witness sled. The CMC receives witness transactions from theses IHSs and utilizes the connection initiated via the management signaling pathway to submit the transactions for processing by the witness sled.

Abstract: The present disclosure describes a method to modify dried polymer films using printed crosslinking agents, including that the crosslinked polymer resulting from the method exhibits greater insolubility compared to crosslinked polymers made where the crosslinking agent and the polymer are combined and applied as a homogenous solution. Articles of manufacture generated by such a method are also disclosed.

Abstract: This disclosure relates to mRNA therapy for the treatment of relaxin-related diseases, disorders or conditions such as, e.g., fibrosis or cardiovascular disease (e.g., acute heart failure or acute coronary syndrome). mRNAs for use in the invention, when administered in vivo, encode relaxin. mRNA therapies of the disclosure increase and/or restore deficient levels of relaxin expression and/or activity in subjects.

Abstract: Methods, systems, and devices for storing data are provided. To store data, a data storage system may include multiple storage nodes and a support node. Copies of data may be stored in the storage nodes. When the data stored by the storage nodes appears to be inconsistent, metadata from the support node may be used to resolve the inconsistencies. The storage nodes and support node may be integrated into a single chassis. The chassis may be a form factor compliant chassis such as a rack unit compliant chassis for mounting to rack rails.

Abstract: The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.

Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.

Abstract: Systems and methods provide witness sled hardware that may be installed in a chassis and that may be updated using management resources of a chassis in which the witness sled is installed. A chassis may include data storage devices and Information Handling Systems (IHSs), each including one or more CPUs (Central Processing Units) configured to cause each respective IHS to store data redundantly to the data storage devices, such as part of a vSAN (Virtual Storage Area Network). The chassis also includes a witness sled configured to provide witness functions, such as to arbitrate discrepancies in the redundantly stored data. The chassis may further include a chassis management controller that receives updates to the witness sled, such as to the witness sled operating system. The update is deconflicted with any pending updates and is transmitted to the witness sled while accounting for the limited resources of the compute sled.

Abstract: Systems and methods provide witness sled hardware installed in a chassis and supported during network failures using management resources of the chassis. A chassis may include data storage devices and Information Handling Systems (IHSs), each configured to store data redundantly to the data storage devices, such as part of a vSAN (Virtual Storage Area Network). The witness sled is configured to provide witness functions, such as to arbitrate discrepancies in the redundantly stored data. The chassis also includes a chassis management controller (CMC) configured to initiate a connection with the witness sled via a management signaling pathway in response to a notification indicating a network fault in a high-speed connection used by the IHSs in communicating with the witness sled. The CMC receives witness transactions from theses IHSs and utilizes the connection initiated via the management signaling pathway to submit the transactions for processing by the witness sled.

Abstract: Systems and methods provide witness sled hardware installed in a chassis and supported during failures using management resources of the chassis. A chassis may include data storage devices and Information Handling Systems (IHSs), each storing data redundantly to the storage devices, such in a vSAN. The witness sled provides witness functions, such as arbitrating discrepancies in the redundantly stored data. The chassis includes a chassis management controller (CMC) that maintains a copy of witness transactions stored by the witness sled based on transaction data transmitted by the witness sled to the CMC via the management signaling pathway. The CMC notifies the IHSs of witness operations supported by the CMC in response to a detected fault in the witness sled and utilizes the copy of witness transactions to process witness transactions from the IHSs while the witness sled is not operational.

Abstract: Systems and methods provide witness sled hardware that may be installed in a chassis and that is configurable using management resources of a chassis in which the witness sled is installed. The chassis may include data storage devices and Information Handling Systems (IHSs), each including one or more CPUs (Central Processing Units) that execute instructions that cause a respective IHS to store data redundantly to the plurality of data storage devices, such as part of a vSAN (Virtual Storage Area Network). The witness sled is configured to provide witness functions, such as arbitrating discrepancies in the redundantly stored data. The chassis includes a management controller that is configured to interface with the witness sled to set up high-speed network connections supported by the witness sled in order to configure the witness sled for providing witness functions within the vSAN, while accounting for the limited resources of the compute sled.

Abstract: Methods and systems for managing the operation of data processing systems are disclosed. A data processing system may include a computing device that may provide computer implemented services. To provide the computer implemented services, hardware components of the data processing system may need to operate in predetermined manners. To manage the operation of the hardware components, the data processing system may cool the hardware components to dissipate heat from the hardware components. The data processing system may include a fan retention mechanism that facilitates orientation of positioning of cooling components used to dissipate the heat from the hardware components.

Abstract: A clamp assembly for orthopedic use having a housing that includes a top surface, a recess, a distal base and a bottom surface, the recess defining a longitudinal axis and extending through the housing from the top surface through the distal base and toward the bottom surface, and at least two through slots, each one of being disposed at a bottom or a side a surface of the housing. The assembly including a securement assembly positionable within the recess in a co-axial relationship to a mating surface on the recess, and a band sized for travel along a predetermined path defined in part by the through slots in the housing, wherein at least one of the through slots is a starting point for travel of the band along the predetermined path.

Abstract: The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.

Abstract: A method of processing EEG data. The EEG data from a user is captured utilizing one or more EEG devices worn by the user. The one or more EEG devices sense EEG data and biometrics of the user. User activity and a status of the user associated with the user is determined. The EEG data is analyzed. The EEG data is compared against control data. A service response is generated for one or more systems in communication with the one or more EEG devices to control the one or more systems.

Abstract: The present disclosure describes a method to modify dried polymer films using printed crosslinking agents, including that the crosslinked polymer resulting from the method exhibits greater insolubility compared to crosslinked polymers made where the crosslinking agent and the polymer are combined and applied as a homogenous solution. Articles of manufacture generated by such a method are also disclosed.

Abstract: A method for point-in-time visualization system management is provided. The method includes receiving organizational structure queries from user interfaces, creating organizational hierarchy database queries from the organizational structure query, and converting the results of those queries into entity change parameters lists and organizational tree structures for display on the user interface. The displayed organizational tree structure and entity change parameters can be filtered via controls available on the user interface.

Abstract: A clamp assembly for orthopedic use having a housing that includes a top surface, a recess, a distal base and a bottom surface, the recess defining a longitudinal axis and extending through the housing from the top surface through the distal base and toward the bottom surface, and at least two through slots, each one of being disposed at a bottom or a side a surface of the housing. The assembly including a securement assembly positionable within the recess in a co-axial relationship to a mating surface on the recess, and a band sized for travel along a predetermined path defined in part by the through slots in the housing, wherein at least one of the through slots is a starting point for travel of the band along the predetermined path.

Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.