Patents by Inventor Michael Allegrezza

Michael Allegrezza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MATERIALS AND METHODS FOR BIOENGINEERED IPSC POPULATIONS
    Publication number: 20240010991
    Abstract: Provided herein are methods of producing bioengineered pluripotent stem cells (iPSCs) and isolated populations thereof.
    Type: Application
    Filed: June 30, 2023
    Publication date: January 11, 2024
    Inventors: Jennifer MCCAFFREY, Iqbal S. GREWAL, Dharmeshkumar PATEL, Michael ALLEGREZZA, Glenn S. COWLEY, HONGXING SUN
  • Method for treatment of metastatic and refractory cancers and tumors with an inducer that overcomes inhibition of T cell proliferation
    Patent number: 10258625
    Abstract: A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule that induces T cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the MEK/MAPK pathway and the T cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo. Compositions and kits including these components are also provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: April 16, 2019
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Jose R. Conejo-Garcia, Michael Allegrezza
  • METHODS AND COMPOSITIONS FOR TREATMENT OF METASTATIC AND REFRACTORY CANCERS AND TUMORS
    Publication number: 20180280393
    Abstract: A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule that induces T cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the MEK/MAPK pathway and the T cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo. Compositions and kits including these components are also provided.
    Type: Application
    Filed: October 5, 2016
    Publication date: October 4, 2018
    Applicant: The Wistar Institute of Anatomy and Biology
    Inventors: Jose R. Conejo-Garcia, Michael Allegrezza
  • METHODS AND COMPOSITIONS FOR TREATMENT OF METASTATIC AND REFRACTORY CANCERS AND TUMORS
    Publication number: 20170326205
    Abstract: A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule that induces T cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the MEK/MAPK pathway and the T cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo. Compositions and kits including these components are also provided.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 16, 2017
    Inventors: Jose R. Conejo-Garcia, Michael Allegrezza
  • Method for treatment of metastatic and refractory cancers and tumors with an inducer that overcomes inhibition of T cell proliferation
    Patent number: 9724393
    Abstract: A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule that induces T cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the MEK/MAPK pathway and the T cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo. Compositions and kits including these components are also provided.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: August 8, 2017
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Jose R. Conejo-Garcia, Michael Allegrezza
  • METHODS AND COMPOSITIONS FOR TREATMENT OF METASTATIC AND REFRACTORY CANCERS AND TUMORS
    Publication number: 20170020964
    Abstract: A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule that induces T cell proliferation in the presence of said inhibitor. The combination of a small molecule inhibitor of a target of the MEK/MAPK pathway and the T cell proliferation inducer reduces the proliferation of the cancer and tumor cells in vivo. Compositions and kits including these components are also provided.
    Type: Application
    Filed: October 5, 2016
    Publication date: January 26, 2017
    Inventors: Jose R. Conejo-Garcia, Michael Allegrezza