Abstract: A nanoelectronic device for detecting target molecules is described. The device has an array of nanoscale wires serving as sensors of target molecules and electrical contacts, electrically contacting the nanowires at end regions of the nanoscale wires. The end regions are covered with an insulating material. The insulating material also defines a window region of the nanoscale wires, not covered by the insulating material. Probe molecules are located on the nanoscale wires along the window region. A microfluidic channel can also be provided, to allow flow of the target molecules. A method of fabricating the nanoelectronic device is also shown and described.