Abstract: A class of polycyclic compounds of general formula (I), of general formula (I?), or of general formula (I?), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract: The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

Abstract: A testing device (1) for a lamp (3) operated at a nominal voltage (Vn) and at a nominal frequency (fn), having a capacitive coupling of a test voltage (Vp) at a testing frequency of (fp) to the lamp (3), wherein a coupled test voltage (Vpa) corresponds to the nominal voltage (Vn), and a coupled test frequency (fpa) corresponds to the nominal frequency (fn). The testing device is capable of testing a gas-filled lamp having integrated upstream electronics between power supply connections and a gas filled portion.

Abstract: A testing device (1) for lighting means (3) operated at a nominal voltage (Vn) and at a nominal frequency (fn), having a capacitive coupling of a test voltage (Vp) at a testing frequency of (fp) to the lighting means (3), wherein a coupled test voltage (Vpa) corresponds to the nominal voltage (Vn), and a coupled test frequency (fpa) corresponds to the nominal frequency (fn).

Abstract: An ice cube-making machine that is characterized by noiseless operation at the location where ice cubes are dispensed and be lightweight packages for ease of installation. The ice cube-making machine has an evaporator package, a separate compressor package and a separate condenser package. Each of these packages has a weight that can generally by handled by one or two installers for ease of installation. The noisy compressor and condenser packages can be located remotely of the evaporator package. The maximum height distance between the evaporator package and the condenser package is greatly enhanced by the three package system. A pressure regulator operates during a harvest cycle to limit flow of refrigerant leaving the evaporator, thereby increasing pressure and temperature of the refrigerant in the evaporator and assisting in defrost thereof. The evaporator can be integrated with a beverage dispenser and an ice dispenser.

Abstract: An evaporator device and method of making the device. The evaporator device comprises a one-piece metallic body, which is preferably aluminum or an alloy thereof, with a refrigerant tube embedded therein. The metallic body further includes horizontal fins and vertical partitions protruding from at least one surface that define an array of ice forming cells. The one-piece metallic body is formed by a die casting process that eliminates the conventional assembly steps of separate evaporator pans, refrigerant tube pieces, vertical partitions horizontal fins and other parts.

Abstract: An ice cube-making machine that is characterized by noiseless operation at the location where ice cubes are dispensed and be lightweight packages for ease of installation. The ice cube-making machine has an evaporator package, a separate compressor package and a separate condenser package. Each of these packages has a weight that can generally by handled by one or two installers for ease of installation. The noisy compressor and condenser packages can be located remotely of the evaporator package. The maximum height distance between the evaporator package and the condenser package is greatly enhanced by the three package system. A pressure regulator operates during a harvest cycle to limit flow of refrigerant leaving the evaporator, thereby increasing pressure and temperature of the refrigerant in the evaporator and assisting in defrost thereof. The evaporator can be integrated with a beverage dispenser and an ice dispenser.

Abstract: The present invention relates to a process for alkylating hindered sulfonamides useful as intermediates in the preparation of matrix metalloproteinase inhibitors.