Abstract: A detachable, retrofitting light accessory for both magnetic and adhesive attachment to a high-heeled shoe having an open archway with a ferrous metal shank, having a light-emitting diode (LED) light assembly, a magnet affixed to the LED light assembly and configured to magnetically engage the ferrous metal shank in the open archway of the shoe, and to magnetically attach the light accessory to the shoe, and a double-sided adhesive strip configured for placement between the magnet and an outer surface in the open archway to also adhesively attach the light accessory to the shoe, to prevent the light accessory from slipping relative to the shoe during use.

Abstract: A method includes determining, by an assistant executing at one or more processors, a default group of actions that the assistant is configured to execute in response to receiving a particular audible command. The method includes determining, by the assistant, based on the default group of actions and a user profile associated with a particular user, a custom group of actions that the assistant is configured to execute in response to receiving the particular audible command from the particular user. The method also includes receiving, by the assistant, an indication of the particular audible command, and determining, by the assistant, whether the indication of particular audible command originated from the particular user. The method further includes, responsive to determining that the indication of particular audible command originated from the particular user, executing, by the assistant, each action from the custom group of actions.

Abstract: The disclosure provides an effervescent composition adapted for oral use, the composition including an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; at least one active ingredient; and optionally, a lipid in an amount of at least about 20% by weight. Melting effervescent compositions are also provided, which include the lipid.

Abstract: A modular gear transmission and associated systems. The modular gear transmission has an assembled configuration, and the modular gear transmission includes a first transmission body and a first transmission gear set. The first transmission gear set includes a first protruding gear, a first intermediate gear set including at least one intermediate transmission gear, and a first transmission socket. The first transmission body is configured so that, when the modular gear transmission is in the assembled configuration, the first transmission body engages the first transmission gear set to hold the first transmission gear set in a rotatable configuration. The first protruding gear is configured so that, when the modular gear transmission is in the assembled configuration, the first protruding gear protrudes from the first transmission body and is rotatably engaged with the first intermediate gear set, the first protruding gear configured to rotate around a first referential axis of rotation.

Abstract: Tetrahydronaphthyridines of formula are disclosed. These compounds selectively inhibit ?V?3 without activating the ?V?3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing ?V?3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.

Abstract: Disclosed herein are platforms, systems, devices, software, and methods for processing and analyzing real-time data to generate predictions of near future events. Machine learning algorithms can be configured for varying levels of aggression to enhance timeliness of the predictions. Ensemble machine learning techniques combining a plurality of trained models configured with higher and lower aggression levels can be used to improve both timeliness and accuracy.

Abstract: Aspects describe a dual-planar retaining piece for stabilizing and securing earpiece in a wearer's ear. The retaining piece is either fixed or removable from the earpiece. The retaining piece includes a first cantilevered portion shaped to flexibly fit under the antitragus of a wearer's ear when the earpiece is worn, a second cantilevered portion shaped to flexibly fit under the antihelix of the wearer's ear when the earpiece is worn, and at least one attachment feature that couples the retaining piece to a body of the earpiece, wherein the body is shaped to fit in the lower concha of the wearer's ear when the earpiece is worn. In aspects, the first and second cantilevered portions are integrally formed.

Abstract: Devices and methods are provided that utilize two adjacent nanopore readers for sequencing of a polymer or a portion thereof.

Abstract: A vacuum pumping arrangement comprises a first pump which has a first inlet and a first outlet. The first inlet is fluidly connected to a first common pumping line. The first common pumping line includes a plurality of first pumping line inlets each of which is fluidly connectable to a least one process chamber within a group of process chambers that form a semiconductor fabrication tool. The vacuum pumping arrangement also includes a reserve pump which has a reserve inlet and a reserve outlet. The reserve inlet is selectively fluidly connectable to each process chamber within the group of process chambers that form the semiconductor fabrication tool. The vacuum pumping arrangement additionally includes a controller which is configured to selectively fluidly isolate the pump from one or more given process chambers and selectively fluidly connect the reserve pump with the said one or more given process chambers.

Abstract: A seating unit is provided that is moveable between closed, extended and fully reclined positions. The seating unit comprises two sides spaced from one another and a seat extending between the two sides, an extendable ottoman and a chair back extending upwardly from a rearward edge of the seat. The seating unit further comprises a side plate adjacent each of the two sides and at least one support tube extending between the side plates. The seating unit has a linkage mechanism supported on the side plates and coupling at least the ottoman and the chair back. A motor is coupled to the linkage mechanism to move the seating unit between the closed, extended and fully reclined positions, wherein the motor extends above the at least one support tube.

Abstract: Safety apparatus including a first monitoring device designed to be locked onto a threatening individual and including GPS apparatus. A second monitoring device designed to be possessed by a threatened victim and including GPS apparatus. A relative motion sensor included in the second monitoring device designed to compare GPS information between the first monitoring device and the second monitoring device and to provide an activating signal when the GPS information indicates closing at a speed greater than the reaction time of the second monitoring device. A rapid response system included in the second monitoring device and connected to receive the activating signal from the relative motion sensor, whereby the rapid response system is activated to send one of a pulse mode and a drive-stun mode to the first monitoring device.

Abstract: Materials, designs, and methods of fabrication for electrodes for electrochemical cells are disclosed. In various embodiments, the electrode comprises iron. Various embodiments may include materials, systems, and methods for the use of various iron-bearing materials, starting from the discharged or partially discharged state in an alkaline electrochemical cell, such as an Fe—Ni, Fe—MnO2, or Fe-air battery. Various embodiments may include a battery comprising an electrode comprising iron. In various embodiments, the iron may be in various forms, such as iron ore, iron concentrate, iron pellets, BF grade pellets, DR grade pellets, hematite, magnetite, wustite, martite, goethite, limonite, siderite, pyrite, ilmenite, spinel manganese ferrite, etc. In various embodiments, the iron may include impurity phases, such as SiO2, CaO, etc.

Abstract: The development of a new, targeted drug delivery paradigm coupled to improved PI3K inhibitors (e.g., PI3K? inhibitors) represents a significant advance in cancer therapy. Provided herein are compounds, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds provided herein are PI3K (e.g., PI3K?) inhibitors and are therefore useful for the treatment and/or prevention of various diseases (e.g., proliferative diseases such as cancer). Also provided herein are nanoparticles and nanogels (e.g., P-selectin targeting nanoparticles) comprising PI3K inhibitors, such a compound described herein. In certain embodiments, a nanoparticle or nanogel described herein encapsulates a compound described herein for targeting delivery to cancer cells or tumors.

Abstract: A progressive cavity pump includes at least one of a jacketed stator casing and a jacketed inlet body. The jacketed stator casing includes a stator heating chamber, a stator assembly, and a rotor rotatably disposed within the stator assembly. The stator heating chamber forms a first space around the stator assembly and receives heating fluid therein. The stator assembly includes a cylindrical wall and a stator segment that forms a helically-convoluted chamber within the cylindrical wall. The jacketed inlet body includes an inlet heating chamber and a working fluid chamber in fluid communication with the helically-convoluted chamber. The inlet heating chamber forms a second space around the working fluid chamber and receives heating fluid therein. The stator heating chamber and the inlet heating chamber are isolated from each other, the helically-convoluted chamber, and the working fluid chamber.

Abstract: Tissue sample cassettes for receiving tissue samples include an upper tray including compartments separated by dividers, a lower tray coupled to the upper tray and having a central recess, and an absorbent material located in the recess of the lower tray. Related systems and methods for automated gross processing of tissue samples are also disclosed.

Abstract: Various embodiments relate to several processes that may recover commodity chemicals from an alkaline metal-air battery. In various embodiments, while the cell is operating, various side products and waste streams may be collected and processed to regain use or additional value. Various embodiments also include processes to be performed after the cell has been disassembled, and each of its electrodes have been separated such as not to be an electrical hazard. The alkaline metal battery recycling processes described herein may provide multiple forms of commodity iron, high purity transition metal ores, fluoropolymer dispersions, various carbons, commodity chemicals, and catalyst dispersions.

Abstract: A method of operation and non-transitory computer readable medium are provided for a mobile communications device which includes memory storing program instructions and a processor coupled to a first input that passively collects input data and a second input that collects response data based on a challenge. A statistical behavioral model is generated based upon passively collected input data for the user. A level of assurance (LOA) is determined based upon the statistical behavioral model and the passively collected input data from the first input. The LOA is compared with a threshold and based on the comparison: the mobile device operation is enabled as a result of determining that the LOA meets or exceeds the threshold without requiring response data from the at least one second input, otherwise, the challenge is generated and the mobile device operation is enabled responsive to valid response data from the second input.

Abstract: A smoking article is provided, having a component housing including a power source, and a tubular housing having a first end and a longitudinally-opposed second end, wherein the first or second end is configured to receive the component housing. The tubular housing includes an outer wall defining a cylindrical cavity. An aerosol-generating element is configured to be received within the cylindrical cavity, wherein the aerosol-generating element is configured to produce an aerosol in response to heat. An associated aerosol-generating element and related production methods are also provided.

Abstract: Our system describes Unlimited Range Drive (URD) capabilities of an electrical automotive vehicle using machine learning technique, assisted by newly designed intelligent battery modules (IBM-R, IBM-D/R) and newly invented high voltage continuous variable power plant (CVPP), our intelligent battery and power plant modules work in harmony and continuously provide feedback to each other, causing a high voltage battery to recharge while other high voltage battery is in use to drive a vehicle, this charging/recharging process and dynamically switching high voltage battery in use is continued until physical life of batteries is exhausted which may be 10 to 15 years, dynamic coordination of the modules with dynamic switching of battery in use archives Unlimited Range Drive (URD) capabilities which may exceed more than 1 million miles drive on a single high voltage battery charge, our URD system provides clean environment and cost effective more than 1 million miles drive solution.