Patents by Inventor Michael Anthony Marella

Michael Anthony Marella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6028063
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compounds of formula III having the structure: ##STR1## wherein Ar and X.sup.7 ;R.sub.1 and R.sub.2 ; andn are as described in the specification.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: February 22, 2000
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 5981513
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: ##STR1## wherein X.sub.4, X.sub.5 ;R.sub.1, R.sub.2 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: March 21, 1998
    Date of Patent: November 9, 1999
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5945443
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formulae IV having the structure: ##STR1## wherein X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ;and n are as described in the specification.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: August 31, 1999
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 5763445
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compounds of formular I, II, III and IV have the structure: ##STR1## wherein X, X.sub.4, X.sub.5, X.sub.7, X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ; andY, Z and n are as described in the specification.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: June 9, 1998
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5744458
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compound of formula II has the structure: ##STR1## wherein X.sub.4, X.sub.5 ;R.sub.1, R.sub.2 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: April 28, 1998
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5688955
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formulae I, II, III and IV have the structure: ##STR1## wherein X, X.sub.4, X.sub.5, X.sub.7, X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ; andY, Z and n are as described in the specification.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: November 18, 1997
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang