Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents methods for preparing thereof, and methods for preparing nucleoside phosphorothioate compounds by using the novel reagents.

Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Abstract: The present invention provides inhibitors of fucosylation during protein expression from mammalian cells. The inhibitors are derived from rhamnose and act by inhibition of GDP-mannose 4,6-dehydratase (GMD). The invention further provides methods of making proteins with reduced level of fucosylation, such as antibodies and antibodies made by the methods of the present invention. Such hypofucosylated or nonfucosylated antibodies may find use, for example, in treatment of human disease in which is it therapeutically eneficial to direct antibody dependent cellular cytotoxicity (ADCC) mediated killing of cells expressing the antibody target on their surface, for example in depletion of Tregs in cancer patients using a hypofucosylated or nonfucosylated anti-CTLA-4 antibody.

Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.

Abstract: Compounds according to formula (I) or (II), wherein R1, R2, and R3 are as defined in the specification, are versatile intermediates for the synthesis of DNA minor groove binder-alkylators having a cyclopropapyrroloindole (CPI) or seco-CPI alkylating subunit.

Abstract: Compounds according to formula (I) or (II), wherein R1, R2, and R3 are as defined in the specification, are versatile intermediates for the synthesis of DNA minor groove binder-alkylators having a cyclopropapyrroloindole (CPI) or seco-CPI alkylating subunit.

Abstract: An improved process for making a compound B of the structure wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.

Abstract: A program product for processing a request for a state of a resource in a distributed processing environment may in general terms comprise receiving an identification of a resource, and identifying a provider associated with an indicator of states of the resource. The program product may further comprise obtaining the state of the resource. The state may be obtained by observing the state in memory shared with the indicator, or by retrieving the state from memory in which the state is contained, or by requesting and receiving the state from a remote provider, depending upon the particular resource.

Abstract: A system for processing a request for a state of a resource in a distributed processing environment may in general terms comprise receiving an identification of a resource, and identifying a provider associated with an indicator of states of the resource. The system may further comprise obtaining the state of the resource. The state may be obtained by observing the state in memory shared with the indicator, or by retrieving the state from memory in which the state is contained, or by requesting and receiving the state from a remote provider, depending upon the particular resource.

Abstract: A method for processing a request for a state of a resource in a distributed processing environment may in general terms comprise receiving an identification of a resource, and identifying a provider associated with an indicator of states of the resource. The method may further comprise obtaining the state of the resource. The state may be obtained by observing the state in memory shared with the indicator, or by retrieving the state from memory in which the state is contained, or by requesting and receiving the state from a remote provider, depending upon the particular resource.

Abstract: A system of processing a request for notice of occurrence of an event in a distributed processing environment may in general terms comprise receiving a request for notice of occurrence of an event, the request including an identification of a resource in which the will occur, and identifying a monitor associated with an indicator of states of the resource. The system may further comprise obtaining indication of the event. The state characterizing the event may be received from the client or may be a default value. Indication of the event may be obtained by receiving state values and determining if they indicate the event, or periodically monitoring the indicator for occurrence of the event, or requesting monitoring from a monitor associated with the indicator.

Abstract: A method of processing a request for notice of occurrence of an event in a distributed processing environment may in general terms comprise receiving a request for notice of occurrence of an event, the request including an identification of a resource in which the will occur, and identifying a monitor associated with an indicator of states of the resource. The method may further comprise obtaining indication of the event. The state characterizing the event may be received from the client or may be a default value. Indication of the event may be obtained by receiving state values and determining if they indicate the event, or periodically monitoring the indicator for occurrence of the event, or requesting monitoring from a monitor associated with the indicator.

Abstract: A program product of processing a request for notice of occurrence of an event in a distributed processing environment may in general terms comprise receiving a request for notice of occurrence of an event, the request including an identification of a resource in which the will occur, and identifying a monitor associated with an indicator of states of the resource. The program product may further comprise obtaining indication of the event. The state characterizing the event may be received from the client or may be a default value. Indication of the event may be obtained by receiving state values and determining if they indicate the event, or periodically monitoring the indicator for occurrence of the event, or requesting monitoring from a monitor associated with the indicator.