Abstract: A polymer masonry unit (PMU) and methods and systems for forming PMUs are presented. In embodiments, a PMU may be made from a PMU mixture of a polymer, a quarry byproduct, such as a limestone aggregate, and water. The PMU may be ambient-dried to become a brick unit. The proportions of the PMU mixture may include 1-10% polymer, 80-90% quarry byproduct, and 1-10% water. The process for making a brick using the PMU of embodiments may avoid a kiln-firing process, which is costly, creates waste, and consumes significant energy. Furthermore, the PMU mixture may be formulated to enable the PMU mixture to be extruded from an extruder, enabling a system for making bricks to take advantage of the extrusion method, which can be very efficient and cost-effective for making bricks, and which is currently not possible with existing techniques and systems.

Abstract: The present invention provides a moisture reduction roller conveyor system (100, 200, 301) and method comprising a continuous carry belt (105, 205, 308) to carry a bulk material and an oscillatory motion assembly (110, 210, 320) operatively connected and configured to induce oscillatory motion of the belt that is transmitted to the bulk material. The oscillatory motion assembly (110) is operatively connected to the frame to induce the oscillatory motion. Alternatively, the oscillatory motion assembly has idler rollers (210a, 210b, 210c) that are offset or eccentric to one another to induce the oscillatory motion. A different oscillatory motion assembly comprises a carriage body (325) for supporting the belt (308) and wheels (340, 345) for engaging a rail track (302). The wheels (340, 345) are configured to induce the oscillatory motion, preferably by periodically lifting one end (360) of the carriage body from the rail track as the carriage moves.

Abstract: Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3; A is a lipophilic, hydrophobic moiety; R1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubstituted or substituted C6 to C24 alkylene or alkenylene group, which is optionally interrupted by one or more —NR9—, —O— or —S— linkages, R2 is —YC(R4)(R5)CO2R6; and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy.

Abstract: Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3; A is a lipophilic, hydrophobic moiety; R1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubstituted or substituted C6 to C24 alkylene or alkenylene group, which is optionally interrupted by one or more —NR9—, —O— or —S— linkages, R2 is —YC(R4)(R5)CO2R6; and pharmaceutically acceptable salts or solvates thereof are useful as endosomolytic agents particularly for the delivery of nucleic acids useful in gene therapy.

Abstract: The Event-Associating Software Application for Accessing Digital Media (the “Software Application”) consists of a Software Application designed to receive messages and digital media files from external sources, then to read and categorize each file's metadata based on events of which the person submitting the file has taken a photograph or a video, or recorded audio. The Software Application parses each file's metadata, looks up events in the System database to match with the digital media file, and associates those events with the message. The Application's parsing function generally comprises reading the metadata, splitting it up into component parts, and categorizing it in databases together with the message data, which consists of EXIF data (Exchangeable Image File Format data, such as time, location, and other related tags) encoded in photograph and audio files and user-generated text and tags that accompany the files.

Abstract: A Venturi Effect fluid Turbine of a Utility Design, that is fashioned in such a way as to maximize energy production from fluids in motion, by mechanically creating a vortex that reduces fluid pressure at the axis of rotation of said art device, thereby causing the free stream velocity to increase as a function of said vortex. Upon a fluid impacting the airfoil(s) or hydrofoil(s) leading edge, a reduction in fluid pressure begins on the curved outside surface of the airfoil(s) or hydrofoils and continues to decrease as the trailing edge is approached by said fluid flow. The difference in fluid flow velocity between the curve side and the concave side of the airfoil(s) or hydrofoil(s) creates a venturi effect at the boundary layer where the low pressure fluid flow of the curve side impacts the higher pressure fluid flow of the concave side.

Abstract: Targeted lipids and lipid particles are described which are assemblies of multipolar lipids, targeting molecules such as antibodies and polyanions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

Abstract: Compounds of formula (1) ##STR1## are described wherein Y represents a halogen atom or a group --OR.sup.1, where R.sup.1 is an optionally substituted alkyl group; R.sup.2 represents an optionally substituted cycloalkyl or cycloalkenyl group; R.sup.3 is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen or sulphur atoms or a group --N(R.sup.4)-- where R.sup.4 is a hydrogen atom or an alkyl group; X is --O--, --S--, or --N(R.sup.5)--, where R.sup.5 is a hydrogen or an alkyl group; with the proviso that when X is --O-- then R.sup.3 is not a 3-cyanamino-6-pyridazinyl or a 3-chloro-6-pyridazinyl group; and the salts, solvates, hydrates and N-oxides thereof.The compounds are selective and potent inhibitors of phosphodiesterase IV and are useful for the prophylaxis and treatment of inflammatory diseases and the alleviation of conditions associated with central nervous malfunction.

Abstract: Compounds of general formula (1): ##STR1## wherein Y is a halogen atom or a group --OR.sup.1 where R.sup.1 is an optionally substituted alkyl group;X is --O--, --S-- or --N(R.sup.8)--, where R.sup.8 is a hydrogen atom or an alkyl group;R.sup.2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group;R.sup.3 is a hydrogen or halogen atom or an --OR.sup.9 group, where R.sup.9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group;R.sup.4 is a group --(CH.sub.2).sub.n Ar, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1,2 or 3;R.sup.5 is a C.sub.3-9 carbocyclic ketone optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms;R.sup.6 is a hydrogen atom or an optionally substituted alkyl group;R.sup.

Abstract: Compounds of formula (1) ##STR1## are described wherein Y represents a halogen atom or a group --OR.sup.1, where R.sup.1 is an optionally substituted alkyl group; R.sup.2 represents an optionally substituted cycloalkyl or cycloalkenyl group; R.sup.3 is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen or sulphur atoms or a group --N(R.sup.4)-- where R.sup.4 is a hydrogen atom or an alkyl group; X is --O--, --S--, or --N(R.sup.4)--, where R.sup.5 is a hydrogen or an alkyl group; with the proviso that when X is --O-- then R.sup.3 is not a 3-cyanamino-6-pyridazinyl or a 3-chloro-6-pyridazinyl group; and the salts, solvates, hydrates and N-oxides thereof.The compounds are selective and potent inhibitors of phosphodiesterase IV and are useful for the prophylaxis and treatment of inflammatory diseases and the alleviation of conditions associated with central nervous malfunction.

Abstract: Poly(5-hydroxycytidylic acids), produced by the enzymatic polymerization of 5-hydroxycytidylic acid, possess the ability to induce the production of interferon and, furthermore, exhibit anti-viral properties.