Patents by Inventor Michael Antoniou
Michael Antoniou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10576168Abstract: The present invention relates to the prevention and/or treatment of lysosomal storage diseases in a patient.Type: GrantFiled: December 16, 2016Date of Patent: March 3, 2020Assignee: UCL Business LTDInventors: Bobby Gaspar, Adrian Thrasher, Michael Antoniou, Claudia Montiel-Equihua
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Publication number: 20170173184Abstract: The present invention relates to the prevention and/or treatment of lysosomal storage diseases in a patient.Type: ApplicationFiled: December 16, 2016Publication date: June 22, 2017Inventors: Bobby GASPAR, Adrian THRASHER, Michael ANTONIOU, Claudia MONTIEL-EQUIHUA
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Patent number: 8058028Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: September 22, 2008Date of Patent: November 15, 2011Assignee: Millipore CorporationInventors: Michael Antoniou, Robert L Crombie
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Publication number: 20100112640Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: September 22, 2008Publication date: May 6, 2010Inventors: Michael Antoniou, Robert L. Crombie
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Patent number: 7442787Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE). The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: March 22, 2005Date of Patent: October 28, 2008Assignee: Millipore CorporationInventors: Michael Antoniou, Robert Crombie
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Publication number: 20070256932Abstract: The invention provides low cost methods and apparatus that utilize at least one carbon-filled polymeric electrode to electrolytically generate desirable products.Type: ApplicationFiled: May 8, 2007Publication date: November 8, 2007Applicant: SIEMENS WATER TECHNOLOGIES CORP.Inventors: Barry L. Martin, Vadim Zolotarsky, Irina A. Ivanter, Michael Antoniou
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Patent number: 6964951Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: August 21, 2002Date of Patent: November 15, 2005Assignee: M.L. Laboratories PLCInventors: Michael Antoniou, Robert Crombie
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Patent number: 6949361Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) that does not occur in nature. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector and use of the polynucleotide, vector or host cell in therapy, or for in vitro protein expression applications.Type: GrantFiled: September 20, 2001Date of Patent: September 27, 2005Assignee: M.L. Laboratories PLCInventors: Michael Antoniou, Robert L. Crombie, Steven G. Williams
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Publication number: 20050181428Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present inverition also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: March 22, 2005Publication date: August 18, 2005Inventors: Michael Antoniou, Robert Crombie
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Patent number: 6881556Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: August 21, 2002Date of Patent: April 19, 2005Assignee: M. L. Laboratories PLCInventors: Michael Antoniou, Robert Crombie
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Patent number: 6797494Abstract: Selph-replicating, locus control region (LCR)-containing, episomal expression vectors for tissue-specific gene expression for long-term persistent, tissue-specific expression of a gene of interest are described.Type: GrantFiled: February 9, 1999Date of Patent: September 28, 2004Assignee: Medical Research CouncilInventors: Michael Antoniou, Frankin G. Grosveld
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Publication number: 20040038402Abstract: The present invention concerns the use of a nucleic acid fragment comprising a portion of at least 100 contigous nucleotide bases which portion has a sequence the same as, or homologous to a portion of corresponding length of the sequence as set out in SEQ ID NO:1 starting at nucleotide approximately 1 and ending at nucleotide approximately 16879 or the same as, or homologous to a portion of the corresponding length of the sequence complementary to said SEQ ID NO: 1 within the specified positions, for improving the persistence of transfected cells expressing one or more gene(s) of interest operably linked to said acid nucleic fragment. The invention also relates to an expression cassette for the expression of one or more gene(s) of interest which expression is controlled by one or more control sequence(s) and a nucleic acid fragment as defined above.Type: ApplicationFiled: March 4, 2003Publication date: February 26, 2004Inventors: Michael Antoniou, Selina Raguz, Eric Jacobs, Nathalie Silvestre
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Patent number: 6689606Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: GrantFiled: July 21, 1999Date of Patent: February 10, 2004Assignee: M.L. Laboratories PLCInventors: Michael Antoniou, Robert Crombie
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Publication number: 20030082599Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: May 1, 2003Applicant: WOODCOCK WASHBURN LLPInventors: Michael Antoniou, Robert Crombie
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Publication number: 20030061628Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: March 27, 2003Inventors: Michael Antoniou, Robert Crombie
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Publication number: 20030061627Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: March 27, 2003Inventors: Michael Antoniou, Robert Crombie
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Publication number: 20030018986Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of FIG. 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: August 21, 2002Publication date: January 23, 2003Inventors: Michael Antoniou, Robert Crombie
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Publication number: 20020106789Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from13.The polynucleotide of any one of claims 1 to 7, wherein the UCOE comprises the sequence of Figure 20 between nucleotides 1 to 7627 or a functional homologue or fragment thereof. an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleotide, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.Type: ApplicationFiled: July 21, 1999Publication date: August 8, 2002Applicant: Cobra therapeutics LimitedInventors: Michael Antoniou , Robert Crombie
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Publication number: 20020094967Abstract: The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) that does not occur in nature. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector and use of the polynucleotide, vector or host cell in therapy, or for in vitro protein expression applications.Type: ApplicationFiled: September 20, 2001Publication date: July 18, 2002Inventors: Michael Antoniou, Robert L. Crombie
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Patent number: 5538885Abstract: Expression systems which comprise a mammalian host, such as erythroid cells, transformed with a vector which comprises a promoter, a DNA sequence which codes for a desired polypeptide and a dominant control region. The vectors and methods for preparing polypeptides using the expression systems are also described. In a preferred embodiment, the vector contains cDNA for the desired polypeptide and a sequence which is capable of stabilising mRNA produced from the cDNA. The expression systems are particularly efficient and are capable of secreting the desired polypeptide.Type: GrantFiled: January 27, 1994Date of Patent: July 23, 1996Assignee: Imperial Chemical Industries PLCInventors: Melvyn Hollis, Maurice R. C. Needham, Clare Gooding, Franklin G. Grosveld, Michael Antoniou