Patents by Inventor Michael Apicella

Michael Apicella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240156970
    Abstract: This disclosure relates generally to Neisseria surface moieties. More particularly, the present disclosure relates to oligosaccharides corresponding to Neisseria lipooligosaccharides and to chimeric molecules comprising these moieties for eliciting an immune response to Neisseria organisms and/or for treating or inhibiting the development of Neisseria infections.
    Type: Application
    Filed: March 14, 2022
    Publication date: May 16, 2024
    Inventors: Michael Jennings, Feda (En-Chi) Jen, Kate Seib, Evegny Semchenko, Milton Kiefel, Michael Apicella
  • Publication number: 20070104736
    Abstract: A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional HtrB protein, resulting in a mutant that lacks one or more secondary acyl chains and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, or the endotoxin isolated therefrom, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically effective amount of the vaccine formulation.
    Type: Application
    Filed: March 23, 2005
    Publication date: May 10, 2007
    Inventors: Michael Apicella, Melvin Sunshine, Na-Gyong Lee, Bradford Gibson
  • Publication number: 20070048331
    Abstract: A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutant that lacks one or more secondary acyl chains contained in the wild type gram-negative bacterial pathogen, and displays substantially reduced toxicity as compared to the wild type strain. Also, the present invention provides methods for using a vaccine formulation containing the htrB mutant, the endotoxin isolated therefrom, or the endotoxin isolated therefrom which is then conjugated to a carrier protein, to immunize an individual against infections caused by gram-negative bacterial pathogens by administering a prophylactically. effective amount of the vaccine formulation.
    Type: Application
    Filed: January 12, 2006
    Publication date: March 1, 2007
    Inventors: Michael Apicella, Melvin Sunshine, Na-Gyong Lee, Rasappa Arumugham, Bradford Gibson
  • Publication number: 20060257961
    Abstract: This invention relates to purified sialic acid permease systems, and inhibitory agents of sialic acid permease systems.
    Type: Application
    Filed: January 13, 2006
    Publication date: November 16, 2006
    Inventors: Michael Apicella, Anthony Zaleski, Bradford Gibson, Simon Allen
  • Publication number: 20060099691
    Abstract: Compositions and methods for making complex carbohydrates in a bacterial production cell are disclosed. The complex carbohydrates that can be made include oligosaccharides and polysaccharides of bacterial or mammalian origin.
    Type: Application
    Filed: May 18, 2000
    Publication date: May 11, 2006
    Inventors: Michael Apicella, Bradford Gibson, Nancy Phillips