Abstract: The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.

Abstract: The present invention is drawn to systems and methods for reducing unintended use of an active ingredient, such as residual active ingredients present in spent dermal patches and peels. The system can include a dermal patch including an active ingredient and a destructive agent configured to chemically react with the active ingredient. The destructive agent can be present in a container or an absorber. In one embodiment, the absorber can be used within the container. The container can be configured to receive the dermal patch such that the active ingredient contacts the destructive agent within the container. The absorber can be configured to contact the dermal patch such that the active ingredient contacts the destructive agent of the absorber. Additionally, systems and methods for impeding the unintended use of an active ingredient, such as those present in dermal patches or peels, are also provided.

Abstract: An analog-to-digital metering circuit includes a first programmable gain amplifier to amplify a first voltage signal from a first channel before being received by a first analog-to-digital converter that converts the amplified first voltage signal to a first digital signal. A second programmable gain amplifier amplifies a second voltage signal from a second channel and feds the amplified signal to a second analog-to-digital converter that converts the amplified second voltage signal to a second digital signal. A first lowpass filter circuit receives the first and second digital signals, to generate therefrom, a multi-bit analog-to-digital value. A direct digital synthesizer generates a digital signal representing a predetermined waveform that is fed to a digital-to-analog converter. The second voltage signal and the digital signal representing the predetermined waveform are multiplied together to generate a digital value.

Abstract: Systems and methods for attenuating a panic attack are provided. Such methods can comprise steps of delivering a drug to a subject such that the drug forms a depot beneath a skin surface, wherein the drug is suitable for attenuating a panic attack if delivered in a pharmaceutically effective amount into systemic circulation of the subject; and applying heat to the skin surface when the subject experiences an onset of the panic attack, thereby causing the pharmaceutically effective amount of the drug to rapidly enter systemic circulation from the depot.

Abstract: An analog-to-digital metering circuit includes a first programmable gain amplifier to amplify a first voltage signal from a first channel before being received by a first analog-to-digital converter that converts the amplified first voltage signal to a first digital signal. A second programmable gain amplifier amplifies a second voltage signal from a second channel and feds the amplified signal to a second analog-to-digital converter that converts the amplified second voltage signal to a second digital signal. A first lowpass filter circuit receives the first and second digital signals, to generate therefrom, a multi-bit analog-to-digital value. A direct digital synthesizer generates a digital signal representing a predetermined waveform that is fed to a digital-to-analog converter. The second voltage signal and the digital signal representing the predetermined waveform are multiplied together to generate a digital value.

Abstract: A bus interface is provided including a first bus transmission medium adapted for being connected to a control signal source which generates a plurality of sequential control signals. During use, the first bus transmission medium serves to communicate the sequential control signals. Associated with the first bus transmission medium is a second bus transmission medium that is in communication with at least one peripheral device. Such device generates an output signal on the second bus transmission medium upon actuation. Tracking circuitry is connected to the device and remains in communication with the first bus transmission medium. By this interconnection, the tracking circuitry is capable of actuating the device upon the receipt of at least one of the sequential control signals that is associated with the device and is distinguishable by a unique sequential order amongst the remaining sequential control signals.

Abstract: A bus interface is provided including a first bus transmission medium adapted for being connected to a control signal source which generates a plurality of sequential control signals. During use, the first bus transmission medium serves to communicate the sequential control signals. Associated with the first bus transmission medium is a second bus transmission medium that is in communication with at least one peripheral device. Such device generates an output signal on the second bus transmission medium upon actuation. Tracking circuitry is connected to the device and remains in communication with the first bus transmission medium. By this interconnection, the tracking circuitry is capable of actuating the device upon the receipt of at least one of the sequential control signals that is associated with the device and is distinguishable by a unique sequential order amongst the remaining sequential control signals.

Abstract: The present invention enables data communications between multiple devices over a single wire bus. This single-wire interface can be used for sensors, amplifiers, analog-to-digital converters (ADCs), or any other circuit which would normally have an electrical output. Advantages of the present invention include a reduction in device pin count, conservation of the limited number of I/O pins on the control device, and reduced board layout complexity. Speaking generally, each slave device coupled to the single wire bus interface is assigned a different response time window. This enables multiple slave devices to respond to an initial trigger signal generated by the master device without overlapping responses being generated on the single wire bus interface.