Patents by Inventor Michael Avdenko
Michael Avdenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10208340Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: GrantFiled: December 20, 2017Date of Patent: February 19, 2019Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Publication number: 20180112254Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: ApplicationFiled: December 20, 2017Publication date: April 26, 2018Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Patent number: 9868984Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: GrantFiled: April 19, 2017Date of Patent: January 16, 2018Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Publication number: 20170218432Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: ApplicationFiled: April 19, 2017Publication date: August 3, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Patent number: 9656265Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: GrantFiled: October 31, 2014Date of Patent: May 23, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Patent number: 9545648Abstract: Methods and apparatus are adapted to wash magnetic particles isolated in a vessel. The methods include providing a vessel with wash liquid and a layer of magnetic particles, providing a probe having aspiration capability, positioning a probe tip above the layer of magnetic particles, aspirating at least some of the wash liquid above the layer, positioning the probe tip below the layer, and aspirating at least some of the wash liquid from below the layer of magnetic particles. The suction may be turned off as the probe tip descends past the layer. A novel magnetic particle washing apparatus are disclosed.Type: GrantFiled: May 21, 2013Date of Patent: January 17, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Moses Peter, Michael Avdenko
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Publication number: 20150165491Abstract: Methods and apparatus are adapted to wash magnetic particles isolated in a vessel. The methods include providing a vessel with wash liquid and a layer of magnetic particles, providing a probe having aspiration capability, positioning a probe tip above the layer of magnetic particles, aspirating at least some of the wash liquid above the layer, positioning the probe tip below the layer, and aspirating at least some of the wash liquid from below the layer of magnetic particles. The suction may be turned off as the probe tip descends past the layer. A novel magnetic particle washing apparatus are disclosed.Type: ApplicationFiled: May 21, 2013Publication date: June 18, 2015Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Moses Peter, Michael Avdenko
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Publication number: 20150064775Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: ApplicationFiled: October 31, 2014Publication date: March 5, 2015Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Patent number: 8895267Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: GrantFiled: November 1, 2007Date of Patent: November 25, 2014Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Patent number: 8026101Abstract: The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.Type: GrantFiled: March 28, 2005Date of Patent: September 27, 2011Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Randy Kristopher Bower, Stuart Gilmour MacDonald, James David Shaw, Mark Alan Simon, Michael Avdenko, Joseph John Dambra, David Donald Hyde, Merrit Nyles Jacobs, James Daniel Riall
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Publication number: 20100112567Abstract: A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.Type: ApplicationFiled: November 1, 2007Publication date: May 6, 2010Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Robert Adolfsen, Nicolae Dumitrescu, Michael Avdenko, Dario Svenjak
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Patent number: 7402282Abstract: A sample handler includes a plurality of sealable metering tips, each of the tips, when sealed, containing a fluid volume of a test fluid and in which each of the sealed metering tips acts as an auxiliary sample supply container for use with at least one chemistry system of a clinical analyzer.Type: GrantFiled: July 20, 2001Date of Patent: July 22, 2008Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Michael W. LaCourt, James David Shaw, Michael Avdenko, Lee William David, Dale Robert Ryan
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Publication number: 20050196867Abstract: The invention is a method for detecting failures in an analyzer for conducting clinical assays. Potential errors that can result in assay failures in an analyzer are identified, as are their potential sources. The probability that an error source so identified will result in a clinically significant error is also determined. Available potential detection measures corresponding to the source of potential errors are identified with a combination of such measures selected and implemented based on their probability of detecting such errors within an acceptable limit with a concomitant low probability of the false detection of an assay failure. Each of the measures selected are functionally independent of others chosen to address the source of the error and are not subject to the same inherent means of failed detection. Applications of the method in a clinical analyzer are also presented.Type: ApplicationFiled: March 28, 2005Publication date: September 8, 2005Inventors: Randy Bower, Stuart MacDonald, James Shaw, Mark Simon, Michael Avdenko, Joseph Dambra, David Hyde, Merrit Jacobs, James Riall
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Publication number: 20030026733Abstract: A sample handler includes a plurality of sealable metering tips, each of the tips, when sealed, containing a fluid volume of a test fluid and in which each of the sealed metering tips acts as an auxiliary sample supply container for use with at least one chemistry system of a clinical analyzer.Type: ApplicationFiled: July 20, 2001Publication date: February 6, 2003Inventors: Michael W. LaCourt, James David Shaw, Michael Avdenko, Lee William David, Dale Robert Ryan
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Patent number: 6484556Abstract: The accurate determination of the presence of a fluid in a container is determined by assessing the difference in various pressure readings relative to a threshold value. The method distinguishes between actual aspiration of a fluid and aspiration of a film that can otherwise lead one to believe that fluid has been aspirated when it has not. The method is particularly useful in clinical analyzers such as automated enzyme immunoassay devices.Type: GrantFiled: November 13, 2000Date of Patent: November 26, 2002Assignee: Ortho Clinical Diagnostics, Inc.Inventors: Merrit Jabobs, Michael Avdenko, Christopher Michael Parobek, Jim Shaw
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Patent number: 5138228Abstract: A low-wattage metal-halide discharge lamp has a tube of the double ended type that forms a bulb or envelope, a pair of electrodes, e.g., an anode and a cathode, which penetrate into an arc chamber inside the envelope, and a suitable amount of mercury plus one or more metal halide salts. The electrodes are each formed of a refractory metal, i.e., tungsten wire, extending through the respective necks into the arc chamber. Heat transfer along the tube wall and through the necks is controlled by designing the bulb wall so that the cross sectional areas at the necks and at quarter-chamber planes halfway between the necks and a midplane have a respective quarter chamber loading factor and a neck loading factor each within a desired range. Lamps of this design achieve high efficacy at relatively low power, i.e., below 40 watts.Type: GrantFiled: December 31, 1990Date of Patent: August 11, 1992Assignee: Welch Allyn, Inc.Inventors: Brian J. Thomas, Daniel C. Briggs, Michael Avdenko
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Patent number: 5117154Abstract: A low-wattage metal-halide discharge lamp has a quartz tube of the double-ended type that forms a bulb or envelope, a pair of electrodes, e.g., an anode and a cathode, which penetrate into an arc chamber inside the envelope, and a suitable amount of mercury plus one or more metal halide salts. The electrodes are each formed of a refractory metal, i.e., tungsten wire, extending through the respective necks into the arc chamber. Heat dissipation through the neck is controlled by constructing the quartz shanks to that they have shank segments of a desired surface area that extend from the necks a distance equal to the length of the arc chamber. A shank segment loading factor defined as the rated power divided by the shank segment surface areas, and should be in a target range of 12 to 36 w cm.sup.-2. Lamps of this design achieve high efficacy at relatively low power, i.e., below 30 watts.Type: GrantFiled: December 31, 1990Date of Patent: May 26, 1992Assignee: Welch Allyn, Inc.Inventors: Brian J. Thomas, Daniel C. Briggs, Michael Avdenko