Patents by Inventor Michael Aye
Michael Aye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11851720Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.Type: GrantFiled: April 10, 2020Date of Patent: December 26, 2023Assignee: Quest Diagnostics Investments LLCInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
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Publication number: 20230235412Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.Type: ApplicationFiled: November 14, 2022Publication date: July 27, 2023Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
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Patent number: 11499199Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.Type: GrantFiled: October 29, 2019Date of Patent: November 15, 2022Assignee: Quest Diagnostics Investments LLCInventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
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Publication number: 20200340068Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.Type: ApplicationFiled: April 10, 2020Publication date: October 29, 2020Applicant: Quest Diagnostics Investments LLCInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
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Publication number: 20200123596Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.Type: ApplicationFiled: October 29, 2019Publication date: April 23, 2020Applicant: Quest Diagnostics Investments LLCInventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
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Patent number: 10619220Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.Type: GrantFiled: October 7, 2016Date of Patent: April 14, 2020Assignee: Quest Diagnostics Investments IncorporatedInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
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Patent number: 10465252Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.Type: GrantFiled: May 7, 2008Date of Patent: November 5, 2019Assignee: Quest Diagnostics Investments IncorporatedInventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
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Patent number: 10407739Abstract: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.Type: GrantFiled: September 19, 2014Date of Patent: September 10, 2019Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Lakshmi Nair, Heather Vincent, Huong Mai, Michael Aye, Michelle Tabb, Maurice Exner
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Patent number: 10260113Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.Type: GrantFiled: December 11, 2012Date of Patent: April 16, 2019Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Jules Chen, Lilly I. Kong, Ming-Chou Lee, Fan Chen, Michelle M. Tabb, Michael Aye
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Publication number: 20170081735Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods as-saying saying extracted nucleic acids.Type: ApplicationFiled: October 7, 2016Publication date: March 23, 2017Applicant: Quest Diagnostics Investments IncorporatedInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
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Patent number: 9464331Abstract: Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction.Type: GrantFiled: July 6, 2012Date of Patent: October 11, 2016Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
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Patent number: 9194006Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.Type: GrantFiled: July 6, 2012Date of Patent: November 24, 2015Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Jules Chen, Michelle M. Tabb, Michael Aye, Emberlee Eleazar
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Publication number: 20150087545Abstract: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.Type: ApplicationFiled: September 19, 2014Publication date: March 26, 2015Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Lakshmi Nair, Heather Vincent, Huong Mai, Michael Aye, Michelle Tabb, Maurice Exner
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Publication number: 20140234830Abstract: Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction.Type: ApplicationFiled: July 6, 2012Publication date: August 21, 2014Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Maurice Exner, Luca Jacky, Yin-Peng Chen, Huong Mai, Michelle M. Tabb, Michael Aye
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Publication number: 20130022963Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.Type: ApplicationFiled: July 6, 2012Publication date: January 24, 2013Inventors: MAURICE EXNER, LUCA JACKY, YIN-PENG CHEN, HUONG MAI, JULES CHEN, MICHELLE M. TABB, MICHAEL AYE, EMBERLEE ELEAZAR
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Patent number: 8354230Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.Type: GrantFiled: December 21, 2007Date of Patent: January 15, 2013Assignee: Quest Diagnostics Investments Inc.Inventors: Jules Chen, Lilly I. Kong, Ming-Chou Lee, Fan Chen, Michelle M. Tabb, Michael Aye
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Publication number: 20090226889Abstract: The present invention generally relates to a molecular test of enterovirus, herpes simplex virus-1 and -2, and/or Varicella-Zoster virus, in order to identify patients with a viral infection, in particular a viral infection of the central nervous system. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a biological sample comprising, wherein the target nucleic acids comprise the 5? UTR of the enterovirus genome, UL29 of herpes simplex virus and gene 36 of Varicella-Zoster virus.Type: ApplicationFiled: January 14, 2008Publication date: September 10, 2009Inventors: Fan Chen, Lilly I. Kong, Ming-Chou Lee, Jules Chen, Michelle M. Tabb, Michael Aye
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Publication number: 20090197262Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.Type: ApplicationFiled: May 7, 2008Publication date: August 6, 2009Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
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Publication number: 20090181360Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.Type: ApplicationFiled: December 21, 2007Publication date: July 16, 2009Inventors: Jules Chen, Lilly I. Kong, Ming-Chou Lee, Fan Chen, Michelle M. Tabb, Michael Aye
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Publication number: 20090092969Abstract: Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.Type: ApplicationFiled: October 9, 2007Publication date: April 9, 2009Inventors: Michael Aye, Ming-Chou Lee, Lilly I. Kong, Michelle M. Tabb, Fan Chen, Jules Chen