Patents by Inventor Michael B. Austin

Michael B. Austin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INCORPORATION OF TYPE III POLYKETIDE SYNTHASES INTO MULTIDOMAIN PROTEINS OF THE TYPE I AND III POLYKETIDE SYNTHASE AND FATTY ACID SYNTHASE FAMILIES
    Publication number: 20120122180
    Abstract: Recombinant fusion proteins in which intermediates are covalently bound to the fusion proteins and transferred between domains of the fusion proteins are provided. The fusion proteins include proteins having type I polyketide or fatty acid synthase domains fused with type III polyketide synthase domains. Methods of making such recombinant fusion proteins and methods using such proteins to produce polyketide and other products are described.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: Salk Institute for Biological Studies
    Inventors: Michael B. Austin, Joseph P. Noel, Marianne E. Bowman
  • METHODS OF PRODUCING POLYKETIDE SYNTHASE MUTANTS AND COMPOSITIONS AND USES THEREOF
    Publication number: 20120096581
    Abstract: The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acid encoding such non-native polyketide synthases. Also disclosed are methods of producing mutant polyketide synthases, and methods of altering the activity and/or substrate specificity of putative polyketide synthases.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 19, 2012
    Inventors: Joseph P. Noel, Michael B. Austin, Marianne E. Bowman
  • Methods of producing polyketide synthase mutants and compositions and uses thereof
    Patent number: 7807424
    Abstract: The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acid encoding such non-native polyketide synthases. Also disclosed are methods of producing mutant polyketide synthases, and methods of altering the activity and/or substrate specificity of putative polyketide synthases.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: October 5, 2010
    Assignee: The Salk Institute for Biological Studies
    Inventors: Joseph P. Noel, Michael B. Austin, Marianne E. Bowman
  • METHODS OF PRODUCING POLYKETIDE SYNTHASE MUTANTS AND COMPOSITIONS AND USES THEREOF
    Publication number: 20090271888
    Abstract: The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acid encoding such non-native polyketide synthases. Also disclosed are methods of producing mutant polyketide synthases, and methods of altering the activity and/or substrate specificity of putative polyketide synthases.
    Type: Application
    Filed: October 22, 2007
    Publication date: October 29, 2009
    Inventors: Joseph P. Noel, Michael B. Austin, Marianne E. Bowman
  • Incorporation of type III polyketide synthases into multidomain proteins of the type I and III polyketide synthase and fatty acid synthase families
    Publication number: 20080233628
    Abstract: Recombinant fusion proteins in which intermediates are covalently bound to the fusion proteins and transferred between domains of the fusion proteins are provided. The fusion proteins include proteins having type I polyketide or fatty acid synthase domains fused with type III polyketide synthase domains. Methods of making such recombinant fusion proteins and methods using such proteins to produce polyketide and other products are described.
    Type: Application
    Filed: September 13, 2007
    Publication date: September 25, 2008
    Inventors: Michael B. Austin, Joseph P. Noel, Marianne E. Bowman
  • Methods of producing polyketide synthase mutants and compositions and uses thereof
    Patent number: 7285380
    Abstract: The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of producing mutant polyketide synthases, and methods of altering the activity and/or substrate specificity of putative polyketide synthases.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: October 23, 2007
    Assignee: The Salk Institute for Biological Studies
    Inventors: Joseph P. Noel, Michael B. Austin, Marianne E. Bowman
  • Combined cap and ball glove
    Patent number: 5907871
    Abstract: A combination cap/glove selectively usable as a cap worn on a person's head and a glove worn on a person's hand for catching a ball. The cap/glove includes a concave crown having a peripheral bottom edge, an interior surface and an exterior surface. A hand receptacle having an opening is mounted to a first side of the crown. A band of flexible sheet material having a top and a bottom edge is attached by the bottom edge of the band to the interior surface of the crown at a second side of the crown substantially opposite the first side of the crown. The band is attached to the crown in a manner biasing the top edge of the band away from the crown interior to define a ball catching pocket opposite the hand receptacle.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: June 1, 1999
    Inventor: Michael B. Austin