Patents by Inventor Michael B. Cooper

Michael B. Cooper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190345152
    Abstract: Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
    Type: Application
    Filed: November 29, 2017
    Publication date: November 14, 2019
    Inventors: Arshad M. Siddiqui, Stephane Ciblat, Martin Dery, Lea Constantineau-Forget, Chantal Grand-Maitre, Nicolas Bruneau-Latour, Gerald W. Shipps, Alan B. Cooper, Vibha Oza, Matthew W. Kostura, Michael Luther, Jedd Levine
  • Publication number: 20190301493
    Abstract: A fan system for improved external case fan design with self-cleaning bristles, the fan system includes a housing a housing defining an opening and an interior space that extends along an axis, a plurality of fan blades positioned within the interior space and configured to rotate about the axis, and bristles positioned proximate to the opening of the housing. The fan system also includes one or more brushes configured to rotate about the axis and to be moved to a position to engage the bristles for cleaning and a mechanism configured to move the brushes to the position for engaging the bristles.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 3, 2019
    Inventors: Ralph Saul Cooper, Michael Charles Elles, Robert Anthony Fenoglio, Paul Klustaitis, Luis Quinones Sepulveda, Jeffrey B. Williams
  • Publication number: 20190275357
    Abstract: A portable positive air filtration device including a respiration component and a harness component. The harness component being connected with the respiration component so as to secure the respiration component against the face of a user and covering the mouth and nostril of the user. One or more fans or air-moving components, one or more filters and at least one power supply provide filtered air to the user at a positive pressure. In some examples, the device includes a mask housing, a filter, a fan and an electronics control system. One or more batteries are provided for powering the device. The electronic control system can be connected with an electronic device for real time monitoring and control.
    Type: Application
    Filed: March 11, 2019
    Publication date: September 12, 2019
    Applicants: P&B Innovations LLC, AUBURN UNIVERSITY
    Inventors: Melvin Merri PALMER, JR., Jerry Dwayne BRITTON, David F. DYER, John A. KLINNER, Adam L. LOGAN, Corey M. COX, Morgan I. COOPER, Thomas J. BRACKIN, Ritu SINGH, Christopher L. BRIGHT, Evans A. CARR, Landon B. CARTWRIGHT, Sangyun GO, Michael T. JONES, Brandon M. WEAVER
  • Patent number: 10308718
    Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: June 4, 2019
    Assignee: ALECTOR LLC
    Inventors: Arnon Rosenthal, Tina Schwabe, Michael Kurnellas, Robert Pejchal, Anthony B. Cooper
  • Patent number: 10206950
    Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: February 19, 2019
    Assignees: Smith & Nephew, Inc., Pall Corporation
    Inventors: Samuel O. Sowemimo-Coker, Marcus Lee Scott, Marc Long, Ed Margerrison, Michael B. Cooper
  • Patent number: 9707317
    Abstract: A porous medical implant and a method of making same is described. The medical implant comprises a porous surface formed by application of pulsed electrical energy ins such a way as to cause a localized heating in the surface of the material comprising portions of the implant. The method comprises a pulsed current sintering technique.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 18, 2017
    Assignee: Smith & Nephew, Inc.
    Inventors: Gordon Hunter, Vivek Pawar, Daniel A. Heuer, Abraham Salehi, Michael B. Cooper
  • Publication number: 20150164949
    Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.
    Type: Application
    Filed: December 12, 2014
    Publication date: June 18, 2015
    Inventors: Samuel O. Sowemimo-Coker, Marcus Lee Scott, Marc Long, Ed Margerrison, Michael B. Cooper
  • Publication number: 20120245697
    Abstract: A porous medical implant and a method of making same is described. The medical implant comprises a porous surface formed by application of pulsed electrical energy ins such a way as to cause a localized heating in the surface of the material comprising portions of the implant. The method comprises a pulsed current sintering technique.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 27, 2012
    Applicant: Smith & Nephew Inc.
    Inventors: Gordon Hunter, Vivek Pawar, Daniel A. Heuer, Abraham Salehi, Michael B. Cooper
  • Publication number: 20110159053
    Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.
    Type: Application
    Filed: March 2, 2011
    Publication date: June 30, 2011
    Inventors: Samuel O. Sowemimo-Coker, Marcus L. Scott, Marc Long, Ed Margerrison, Michael B. Cooper
  • Patent number: 7923203
    Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: April 12, 2011
    Assignees: Pall Corporation, Smith & Nephew, Inc.
    Inventors: Samuel O. Sowemimo-Coker, Marcus Lee Scott, Marc Long, Ed Margerrison, Michael B. Cooper
  • Patent number: 7858296
    Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: December 28, 2010
    Assignee: Smith & Nephew, Inc.
    Inventors: Samuel O. Sowemimo-Coker, Marcus Lee Scott, Marc Long, Ed Margerrison, Michael B. Cooper
  • Patent number: 7761346
    Abstract: A computer-implemented method of generating a package of advertising inventory items in response to a set of buyer requirements while optimizing both buyer preferences and a station's revenue objectives given an expected demand can include: selecting a set of candidate inventory items from an inventory of inventory items available for presenting advertising spots, where the set of candidate inventory items satisfy a set of buyer preferences; and scoring the set of candidate inventory items with an affinity score.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: July 20, 2010
    Assignee: Agentsmith, Inc.
    Inventors: Michael B. Cooper, R. Paul Gorman
  • Patent number: 7291450
    Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: November 6, 2007
    Assignees: Smith & Nephew, Inc., Pall Corporation
    Inventors: Samuel O. Sowemimo-Coker, Marcus Lee Scott, Marc Long, Ed Margerrison, Michael B. Cooper
  • Publication number: 20040093286
    Abstract: A computer-implemented method of generating a package of advertising inventory items in response to a set of buyer requirements while optimizing both buyer preferences and a station's revenue objectives given an expected demand can include: selecting a set of candidate inventory items from an inventory of inventory items available for presenting advertising spots, where the set of candidate inventory items satisfy a set of buyer preferences; and scoring the set of candidate inventory items with an affinity score.
    Type: Application
    Filed: November 7, 2002
    Publication date: May 13, 2004
    Applicant: Agentsmith, Inc.
    Inventors: Michael B. Cooper, R. Paul Gorman
  • Publication number: 20040019132
    Abstract: The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a granulated bone material, such as demineralized bone matrix. In addition, a processing aid is utilized to facilitate compaction of the granulated bone material and for release of the product from the die.
    Type: Application
    Filed: July 17, 2003
    Publication date: January 29, 2004
    Inventors: Marc Long, Michael B. Cooper, Keith M. Kinnane, Trevor Allen, Jeffrey E. Schryver
  • Patent number: 6630153
    Abstract: The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a granulated bone material, such as demineralized bone matrix. In addition, a processing aid is utilized to facilitate compaction of the granulated bone material and for release of the product from the die.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: October 7, 2003
    Assignee: Smith & Nephew, Inc.
    Inventors: Marc Long, Michael B. Cooper, Keith M. Kinnane, Trevor Allen, Jeff Schryver
  • Publication number: 20030055511
    Abstract: A shaped particle for use in an array of interlocking particles to repair, replace, improve or augment a bone deficiency is provided. The particle is comprised of bone material and, in a preferred embodiment, has six extremities, and the interstitial spaces between the extremities of one particle accept the extremities of an adjacent particle in an array. In a preferred embodiment, the bone material is demineralized bone material. In some embodiments, the particle is suspended in a material that facilitates application of the particle to bone, and the material may contain biological factors that augment bone growth or prevent infection.
    Type: Application
    Filed: March 15, 2002
    Publication date: March 20, 2003
    Inventors: Jeffrey E. Schryver, Michael B. Cooper, Keith M. Kinnane, Marc Long, Trevor Allen, Ed Margerrison, Robert Morgan, Julie A. Bearcroft, Andrew Harrison, William B. Kaiser
  • Publication number: 20020160032
    Abstract: The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a granulated bone material, such as demineralized bone matrix. In addition, a processing aid is utilized to facilitate compaction of the granulated bone material and for release of the product from the die.
    Type: Application
    Filed: February 23, 2001
    Publication date: October 31, 2002
    Inventors: Marc Long, Michael B. Cooper, Keith M. Kinnane, Trevor Allen, Jeff Schryver
  • Publication number: 20020112981
    Abstract: The present invention is directed to a packaging and delivery system for bone graft particles comprising an outer tray which contains an inner tray comprising a bowl of the particles and also, in some embodiments, a mixing and delivery tool and/or a syringe containing a suspension material for the particles, such as a gel. The inner tray is comprised of an anti-moisture coating and a lid comprised of foil. The mixing and delivery tool preferably has a trowel on one end and a tamping rod on the other end, wherein both features facilitate delivery and compression of the bone graft particles to a bone defect site.
    Type: Application
    Filed: October 25, 2001
    Publication date: August 22, 2002
    Inventors: Michael B. Cooper, Stephanie Riley, James C. Harber, Jeff Martin