Patents by Inventor Michael B. Gross

Michael B. Gross has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11648227
    Abstract: This invention relates to methods for treating dry eye and improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands of a mammal, comprising the steps of administering a composition consisting essentially of an effective amount of omega-3 fatty acids on a daily dosage basis to the mammal having inflamed or dysfunctional meibomian glands, wherein the effective amount of omega-3 fatty acids comprises eicosapentaenoic acid (EPA) in an amount greater than 600 mg and in the re-esterified triglyceride form, and wherein the composition administered does not include any additional omega-6 fatty acids beyond the range normally found in the source material of the omega-3 fatty acids. The composition administered may facilitate an increase in levels of anti-inflammatory omega-3's in the meibum composition of the treated meibomian glands of the mammal and a decrease in the levels of inflammatory omega-6's in the meibum composition of the treated meibomian glands.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: May 16, 2023
    Assignee: PRN Physician Recommended Nutriceuticals LLC
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Publication number: 20220184018
    Abstract: This invention relates to methods for treating dry eye and improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands of a mammal, comprising the steps of administering a composition consisting essentially of an effective amount of omega-3 fatty acids on a daily dosage basis to the mammal having inflamed or dysfunctional meibomian glands, wherein the effective amount of omega-3 fatty acids comprises eicosapentaenoic acid (EPA) in an amount greater than 600 mg and in the re-esterified triglyceride form, and wherein the composition administered does not include any additional omega-6 fatty acids beyond the range normally found in the source material of the omega-3 fatty acids. The composition administered may facilitate an increase in levels of anti-inflammatory omega-3's in the meibum composition of the treated meibomian glands of the mammal and a decrease in the levels of inflammatory omega-6's in the meibum composition of the treated meibomian glands.
    Type: Application
    Filed: March 4, 2022
    Publication date: June 16, 2022
    Applicant: PRN PHYSICIAN RECOMMENDED NUTRICEUTICALS LLC
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Patent number: 11077161
    Abstract: This invention relates to methods for administering an effective amount of a dietary or nutritional supplement composition that effectively changes the levels of biomarkers in the synovium of a joint and resulting in decreased pain and ultimately better outcomes for subjects. The formulation comprises an effective amount of the following: Boswellia; Vitamin C; Ginger; Turmeric; Vitamin D3; and Rutin. In a preferred embodiment of the composition of the invention, the composition is substantially free of omega-3 fatty acids.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: August 3, 2021
    Assignee: Orthopedic Solutions LLC
    Inventors: Michael B. Gross, Javad Parvizi
  • Publication number: 20210121430
    Abstract: This invention relates to methods for treating dry eye and improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands of a mammal, comprising the steps of administering a composition consisting essentially of an effective amount of omega-3 fatty acids on a daily dosage basis to the mammal having inflamed or dysfunctional meibomian glands, wherein the effective amount of omega-3 fatty acids comprises eicosapentaenoic acid (EPA) in an amount greater than 600 mg and in the re-esterified triglyceride form, and wherein the composition administered does not include any additional omega-6 fatty acids beyond the range normally found in the source material of the omega-3 fatty acids. The composition administered may facilitate an increase in levels of anti-inflammatory omega-3?s in the meibum composition of the treated meibomian glands of the mammal and a decrease in the levels of inflammatory omega-6?s in the meibum composition of the treated meibomian glands.
    Type: Application
    Filed: October 22, 2020
    Publication date: April 29, 2021
    Applicant: PRN Physician Recommended Nutriceuticals, LLC
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Patent number: 10709680
    Abstract: This invention relates to methods for improving the quality of the meibum composition of the meibomian glands to enhance or improve the lipid layer of the tear and increase tear breakup time by way of elevating the omega-3 index in patients suffering from symptoms of dry eye, posterior blepharitis, and/or meibomian gland dysfunction. The methods comprise administering a supplementation of omega-3 fatty acids to a patient having an inflamed meibomian gland so as to facilitate an increase in the amount of omega-3's acting as an anti-inflammatory and, respectively, decrease the amount of omega-6's (arachidonic acid) acting as an inflammatory in the composition of the meibum, thereby normalizing the lipid layer of the tear and effectively reducing the associated symptoms. In certain embodiments, the supplementation of omega-3's comprises the esterified or re-esterified triglyceride form.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: July 14, 2020
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Publication number: 20200138897
    Abstract: This invention relates to methods for administering an effective amount of a dietary or nutritional supplement composition that effectively changes the levels of biomarkers in the synovium of a joint and resulting in decreased pain and ultimately better outcomes for subjects. The formulation comprises an effective amount of the following: Boswellia; Vitamin C; Ginger; Turmeric; Vitamin D3; and Rutin. In a preferred embodiment of the composition of the invention, the composition is substantially free of omega-3 fatty acids.
    Type: Application
    Filed: March 16, 2018
    Publication date: May 7, 2020
    Inventors: Michael B. Gross, Javad Parvizi
  • Publication number: 20180214407
    Abstract: This invention relates to methods for improving the quality of the meibum composition of the meibomian glands to enhance or improve the lipid layer of the tear and increase tear breakup time by way of elevating the omega-3 index in patients suffering from symptoms of dry eye, posterior blepharitis, and/or meibomian gland dysfunction. The methods comprise administering a supplementation of omega-3 fatty acids to a patient having an inflamed meibomian gland so as to facilitate an increase in the amount of omega-3's acting as an anti-inflammatory and, respectively, decrease the amount of omega-6's (arachidonic acid) acting as an inflammatory in the composition of the meibum, thereby normalizing the lipid layer of the tear and effectively reducing the associated symptoms. In certain embodiments, the supplementation of omega-3's comprises the esterified or re-esterified triglyceride form.
    Type: Application
    Filed: March 2, 2018
    Publication date: August 2, 2018
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Publication number: 20160310456
    Abstract: This invention relates to compositions for reducing levels of arachidonic acid (omega-6) found at the cellular level in tissue after surgery, wherein the composition consists of an effective amount of at least one fatty acid. In certain embodiments, the composition includes omega-3 fatty acids, which may comprise the triglyceride form. The omega-3 fatty acids of the present invention may comprise eicosapentaenoic acid (EPA) in an amount greater than 600 mg. The omega-3 fatty acids may also comprise docosahexaenoic acid (DHA) in an amount greater than 500 mg. In some embodiments, the composition of the present invention comprises an amount of EPA and an amount of DHA in a 3:1 ratio. Correspondingly, the present invention is further directed to methods for reducing inflammation in tissue after surgery.
    Type: Application
    Filed: June 29, 2016
    Publication date: October 27, 2016
    Inventors: S. Gregory Smith, Michael B. Gross
  • Patent number: 9381183
    Abstract: This invention relates to methods for improving changing the quality of the meibum composition of the meibomian glands to enhance or improve the lipid layer of the tear and increase tear breakup time by way of elevating the omega-3 index in patients suffering from symptoms of dry eye, posterior blepharitis, and/or meibomian gland dysfunction. The methods comprise administering a supplementation of omega-3 fatty acids to a patient having an inflamed meibomian gland so as to facilitate an increase in the amount of omega-3's acting as an anti-inflammatory and, respectively, decrease the amount of omega-6's (arachidonic acid) acting as an inflammatory in the composition of the meibum, thereby normalizing the lipid layer of the tear and effectively reducing the associated symptoms. In certain embodiments, the supplementation of omega-3's comprises the esterified or re-esterified triglyceride form.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 5, 2016
    Assignee: Physicians Recommended Nutriceuticals, LLC
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Patent number: 9115078
    Abstract: This invention relates to methods for administering an effective amount of a dietary or nutritional supplement composition that effectively changes the quality of the meibum lipid composition of inflamed or dysfunctional meibomian glands so as to improve or increase tear break up time, reduce tear osmolarity, and elevate the omega-3 index, while reducing or eliminating the symptoms associated with dry eye or meibomianitis. The dietary or nutritional supplement composition administered to the patient suffering from inflamed or dysfunctional meibomian glands comprises an effective amount of omega-3 fatty acids.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: August 25, 2015
    Assignee: Physicians Recommended Nutriceuticals, LLC
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Publication number: 20140024625
    Abstract: This invention relates to methods for improving changing the quality of the meibum composition of the meibomian glands to enhance or improve the lipid layer of the tear and increase tear breakup time by way of elevating the omega-3 index in patients suffering from symptoms of dry eye, posterior blepharitis, and/or meibomian gland dysfunction. The methods comprise administering a supplementation of omega-3 fatty acids to a patient having an inflamed meibomian gland so as to facilitate an increase in the amount of omega-3's acting as an anti-inflammatory and, respectively, decrease the amount of omega-6?s (arachidonic acid) acting as an inflammatory in the composition of the meibum, thereby normalizing the lipid layer of the tear and effectively reducing the associated symptoms. In certain embodiments, the supplementation of omega-3's comprises the esterified or re-esterified triglyceride form.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 23, 2014
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes
  • Publication number: 20130065867
    Abstract: This invention relates to methods for administering an effective amount of a dietary or nutritional supplement composition that effectively changes the quality of the meibum lipid composition of inflamed or dysfunctional meibomian glands so as to improve or increase tear break up time, reduce tear osmolarity, and elevate the omega-3 index, while reducing or eliminating the symptoms associated with dry eye or meibomianitis. The dietary or nutritional supplement composition administered to the patient suffering from inflamed or dysfunctional meibomian glands comprises an effective amount of omega-3 fatty acids.
    Type: Application
    Filed: July 18, 2012
    Publication date: March 14, 2013
    Inventors: S. Gregory Smith, Michael B. Gross, Olav E. Sandnes