Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.

Abstract: A method of inducing an anti-retroviral immune response by counter-acting retro-virus induced anti-apoptosis is disclosed. The present invention relates, at least in part, to agents and methods for treating, inhibiting, vaccinating or controlling HIV. In certain non-limiting aspects, it relates to the reduction of viral load in an HIV-1 infected subject, while simultaneously developing immunological responsiveness within the subject toward HIV-1 that continues after the agent is removed or excreted from the subject's body.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Abstract: The present invention relates to compositions and methods of treating, inhibiting, or controlling HIV infection.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.

Abstract: The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome.

Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.

Abstract: The present invention relates to a system and method for providing location determination in a configured environment in which Global Navigation Satellite System Signals are not available. In this regard, local beacon systems generate spread spectrum CDMA signals that are received by spectral compression units that derive physically meaningful observations without a requirement for correlation of the intercepted energy by means of the known spreading codes. The invention can coexist with communication assets already in place, and the design allows for self calibration, which simplifies installation and usage. The invention has utility in applications in which GNSS signals are unavailable or limited, for example, in warehouse inventory management, in search and rescue operations and in asset tracking in indoor environments.

Abstract: The present invention relates to a system and method for providing location determination in a configured environment in which Global Navigation Satellite System Signals may not be available. In this regard, local beacon systems generate spread spectrum CDMA signals that are received by spectral compression units that derive physically meaningful observations without a requirement for correlation of the intercepted energy by means of the known spreading codes. The invention can coexist with communication assets already in place, and the design allows for self calibration, which simplifies installation and usage. The invention has utility in applications in which GNSS signals are unavailable or limited, for example, in warehouse inventory management, in search and rescue operations and in asset tracking in indoor environments.