Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.

Abstract: A method of inducing an anti-retroviral immune response by counter-acting retro-virus induced anti-apoptosis is disclosed. The present invention relates, at least in part, to agents and methods for treating, inhibiting, vaccinating or controlling HIV. In certain non-limiting aspects, it relates to the reduction of viral load in an HIV-1 infected subject, while simultaneously developing immunological responsiveness within the subject toward HIV-1 that continues after the agent is removed or excreted from the subject's body.

Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Abstract: A system for providing physical state estimation that can include an emitter configured to emit a structured energy emission within a transmission medium. The system can also include a transponder configured to receive the structured energy emission propagated through a transmission medium from the emitter emit the structured energy emission without significant modification of the internal structure of the energy emission. The system can further include an interceptor configured to receive the transponded structured energy emission propagated through a transmission medium from the emitter. The interceptor can also be configured to process the received emissions using spectral compression utilizing a non-linear operation to produce a set of observables suitable for physical state estimation and communicate the set of observables to a physical state estimator. The yet further include a physical state estimator configured to determine member of the relative physical state.

Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.

Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Abstract: The present invention relates to compositions and methods of treating, inhibiting, or controlling HIV infection.

Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.