Patents by Inventor Michael B. Mathews

Michael B. Mathews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10371806
    Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: August 6, 2019
    Assignee: Telecommunications Systems, Inc.
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Patent number: 9857476
    Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: January 2, 2018
    Assignee: Telecommuncation Systems, Inc.
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Patent number: 9849146
    Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: December 26, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Tsafi Pe'ery, Michael B. Mathews, Mainul Hoque, Hartmut M. Hanauske-Abel
  • Publication number: 20170319612
    Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
    Type: Application
    Filed: June 13, 2012
    Publication date: November 9, 2017
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Tsafi Pe'ery, Michael B. Mathews, Mainul Hoque, Hartmut M. Hanauske-Abel
  • Patent number: 9658341
    Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: May 23, 2017
    Assignee: Telecommunication Systems, Inc.
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Patent number: 9455762
    Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: September 27, 2016
    Assignee: Telecommunication Systems, Inc.
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Publication number: 20160199361
    Abstract: A method of inducing an anti-retroviral immune response by counter-acting retro-virus induced anti-apoptosis is disclosed. The present invention relates, at least in part, to agents and methods for treating, inhibiting, vaccinating or controlling HIV. In certain non-limiting aspects, it relates to the reduction of viral load in an HIV-1 infected subject, while simultaneously developing immunological responsiveness within the subject toward HIV-1 that continues after the agent is removed or excreted from the subject's body.
    Type: Application
    Filed: August 19, 2014
    Publication date: July 14, 2016
    Inventors: Hartmut M. Hanauske-Abel, Paul Palumbo, Bernadette M. Cracchiolo, Axel R. Hanauske, Michael B. Mathews
  • Patent number: 9271998
    Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: March 1, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Tsafi Pe'ery, Michael B. Mathews, Mainul Hoque, Hartmut M. Hanauske-Abel
  • Patent number: 9239376
    Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 19, 2016
    Assignee: Telecommunication Systems, Inc.
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Patent number: 9097783
    Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: August 4, 2015
    Assignee: TELECOMMUNICATION SYSTEMS, INC.
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Publication number: 20140206637
    Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
    Type: Application
    Filed: June 13, 2012
    Publication date: July 24, 2014
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Tsafi Pe'ery, Michael B. Mathews, Mainul Hoque, Hartmut M. Hanauske-Abel
  • Publication number: 20140073685
    Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 13, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Tsafi Pe'ery, Michael B. Mathews, Mainul Hoque, Hartmut M. Hanauske-Abel
  • Publication number: 20140062781
    Abstract: The present invention relates to a system and method using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Combining spectral compression with spread spectrum cross correlation provides unique advantages for positioning and navigation applications including carrier phase observable ambiguity resolution and direct, long-code spread spectrum signal acquisition. Alternatively, the present invention also provides unique advantages for establishing the validity of navigation signals in order to counter the possibilities of electronic attack using spoofing and/or denial methods.
    Type: Application
    Filed: May 17, 2013
    Publication date: March 6, 2014
    Applicant: Loctronix Corporation
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Patent number: 8603814
    Abstract: Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: December 10, 2013
    Assignee: Rutgers the State University of New Jersey
    Inventors: Tsafi Pe'ery, Michael B. Mathews, Mainul Hogue, Hartmut Martin Hanauske-Abel
  • Publication number: 20120225093
    Abstract: The present invention relates to compositions and methods of treating, inhibiting, or controlling HIV infection.
    Type: Application
    Filed: October 11, 2011
    Publication date: September 6, 2012
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Michael B. Mathews, Hartmut M. Hanauske-Abel, Tsafi Pe'ery, Mainul Hoque, Paul Palumbo, Deepti Saxena, Darlene D'Alliessi-Gandolfi, Myung-Hee Park
  • Publication number: 20120169542
    Abstract: The present invention relates to a system and method for positioning and navigation using hybrid spectral compression and cross correlation signal processing of signals of opportunity, which may include Global Navigation Satellite System (GNSS) as well as other wideband energy emissions in GNSS obstructed environments. Examples of these signals of opportunity include but are not limited to GPS, GLONASS, cellular Code Division Multiple Access (CDMA) communications signals, and 802.11 Wi-Fi. Combining spectral compression with spread spectrum cross correlation enables extraction of code and carrier observables without the need to implement the tracking loops (e.g. Costas tracking loop) commonly used in conventional GNSS receivers. For applications where dynamics and transmission medium may make it difficult to continuously track carrier phase, the hybrid approach of the present invention has significant utility.
    Type: Application
    Filed: January 23, 2012
    Publication date: July 5, 2012
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Publication number: 20120095058
    Abstract: The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome.
    Type: Application
    Filed: December 1, 2004
    Publication date: April 19, 2012
    Inventors: H., M. Hanauske-Abel, Paul Palumbo, B., M. Cracchiolo, Myung-Hee Park, Edith Wolff, Axel-Rainer Hanauske, Michael B. Mathews, Deepti Saxena, Mainul Hoque
  • Publication number: 20120086606
    Abstract: Doppler Aided Inertial Navigation (DAIN) facilitates the determination of position, velocity and direction of mobile devices operating in highly obstructed GPS/GNSS environments. Delivering high precision, high resolution positioning information using signals of opportunity, the present invention measures the Doppler shift of a moving device using a variety of signals combined with inertial accelerometers and environmental sensors to deliver an autonomous positioning and navigation capability that does not require external infrastructure or a priori knowledge of signal sources.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Inventors: Michael B. Mathews, Peter F. MacDoran
  • Publication number: 20110234454
    Abstract: The present invention relates to a system and method for providing location determination in a configured environment in which Global Navigation Satellite System Signals are not available. In this regard, local beacon systems generate spread spectrum CDMA signals that are received by spectral compression units that derive physically meaningful observations without a requirement for correlation of the intercepted energy by means of the known spreading codes. The invention can coexist with communication assets already in place, and the design allows for self calibration, which simplifies installation and usage. The invention has utility in applications in which GNSS signals are unavailable or limited, for example, in warehouse inventory management, in search and rescue operations and in asset tracking in indoor environments.
    Type: Application
    Filed: February 17, 2011
    Publication date: September 29, 2011
    Applicant: LOCTRONIX CORPORATION
    Inventors: Michael B. Mathews, Kenn L. Gold, Peter F. MacDoran
  • Patent number: 7916074
    Abstract: The present invention relates to a system and method for providing location determination in a configured environment in which Global Navigation Satellite System Signals may not be available. In this regard, local beacon systems generate spread spectrum CDMA signals that are received by spectral compression units that derive physically meaningful observations without a requirement for correlation of the intercepted energy by means of the known spreading codes. The invention can coexist with communication assets already in place, and the design allows for self calibration, which simplifies installation and usage. The invention has utility in applications in which GNSS signals are unavailable or limited, for example, in warehouse inventory management, in search and rescue operations and in asset tracking in indoor environments.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: March 29, 2011
    Assignee: Loctronix Corporation
    Inventors: Michael B. Mathews, Kenn L. Gold, Peter F. MacDoran