Patents by Inventor Michael B. Mc Keown

Michael B. Mc Keown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
    Patent number: 6281330
    Abstract: In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 28, 2001
    Assignee: The Salk Institute Biological Studies
    Inventors: Ronald M. Evans, Michael B. Mc Keown, Anthony E. Oro, William A. Segraves, Tso-Pang Yao
  • Methods of modulating the expression of genes using ultraspiracle receptor
    Patent number: 6265173
    Abstract: In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to trans-activate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 24, 2001
    Assignee: The Salk Institute for Biological Studies
    Inventors: Ronald M. Evans, Michael B. Mc Keown, Anthony E. Oro, William A. Segraves, Tso-Pang Yao