Patents by Inventor Michael B. Seal
Michael B. Seal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240142478Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.Type: ApplicationFiled: January 5, 2024Publication date: May 2, 2024Applicant: Cytiva US LLCInventors: Michael B. Seal, Darren G. Elton, Bojan Isailovic, Jeremy Rautenbach
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Patent number: 11899028Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.Type: GrantFiled: December 18, 2020Date of Patent: February 13, 2024Assignee: Cytiva US LLCInventors: Michael B. Seal, Darren G. Elton, Bojan Isailovic, Jeremy Rautenbach
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Patent number: 11814200Abstract: A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.Type: GrantFiled: September 23, 2022Date of Patent: November 14, 2023Assignee: Cytiva US LLCInventors: Michael B. Seal, Bojan Isailovic, Robert Flisar, Jeremy Rautenbach
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Publication number: 20230211905Abstract: A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.Type: ApplicationFiled: September 23, 2022Publication date: July 6, 2023Applicant: Pall CorporationInventors: Michael B. Seal, Bojan Isailovic, Robert Flisar, Jeremy Rautenbach
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Publication number: 20210197142Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The manifold includes a buffer inlet line in selective fluid communication with the supply of concentrated buffer solution, a WFI inlet line in selective fluid communication with the source of WFI, and a discharge line in fluid communication with both the buffer inlet line and the WFI inlet line. The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions.Type: ApplicationFiled: December 18, 2020Publication date: July 1, 2021Applicant: Pall CorporationInventors: Michael B. Seal, Matthew J. Loveless
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Publication number: 20210199679Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.Type: ApplicationFiled: December 18, 2020Publication date: July 1, 2021Applicant: Pall CorporationInventors: Michael B. Seal, Darren G. Elton, Bojan Isailovic, Jeremy Rautenbach
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Publication number: 20210197189Abstract: A buffer management system includes a supply of concentrated buffer solution, an inline dilution skid having a manifold in fluid communication with the supply of concentrated buffer solution and a control unit configured to operate the dilution skid to selectively dilute the supply of concentrated buffer solution in the manifold with a source of water for injection (WFI), and a biocontainer assembly. The biocontainer assembly includes a biocontainer bag defining a storage volume and a fill level sensor configured to generate a fill level signal indicative of the amount of material within the storage volume of the biocontainer bag. The biocontainer bag is in fluid communication with the manifold of the dilution skid for storing diluted buffer solution therein. The fill level sensor communicates the fill level signal to the control unit of the dilution skis, which uses it to manage the operation of the dilution skid.Type: ApplicationFiled: December 18, 2020Publication date: July 1, 2021Applicant: Pall CorporationInventors: Bojan Isailovic, Michael B. Seal, Matthew J. Loveless, Robert Flisar, Damir F. Söhngen
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Publication number: 20210199484Abstract: A biocontainer assembly includes a biocontainer bag, a support frame, and a capacitive fill level sensor. The biocontainer bag defines a storage volume. The support frame includes a shelf having a support surface disposed at an oblique angle with respect to a horizontal axis. The capacitive fill level sensor is mounted to the support surface and is configured to generate a fill level signal indicative of the amount of material within the storage volume of the biocontainer bag.Type: ApplicationFiled: December 18, 2020Publication date: July 1, 2021Applicant: Pall CorporationInventors: Michael B. Seal, Matthew J. Loveless
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Patent number: 9714405Abstract: Bioprocessing container tube management systems, totes including the systems, and methods of using the systems, are disclosed.Type: GrantFiled: April 14, 2015Date of Patent: July 25, 2017Assignee: PALL CORPORATIONInventors: Michael B. Seal, Nicholas L. Yoward
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Patent number: 9687852Abstract: Supports for biocontainer bags and systems, and methods of using the supports and systems, are disclosed.Type: GrantFiled: April 14, 2015Date of Patent: June 27, 2017Assignee: PALL CORPORATIONInventors: Michael B. Seal, Paul Clark
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Publication number: 20160304822Abstract: Bioprocessing container tube management systems, totes including the systems, and methods of using the systems, are disclosed.Type: ApplicationFiled: April 14, 2015Publication date: October 20, 2016Inventors: Michael B. SEAL, Nicholas L. Yoward
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Publication number: 20160303567Abstract: Supports for biocontainer bags and systems, and methods of using the supports and systems, are disclosed.Type: ApplicationFiled: April 14, 2015Publication date: October 20, 2016Inventors: Michael B. SEAL, Paul CLARK
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Patent number: 4917519Abstract: A writing instrument has a retraction mechanism of simple, inexpensive construction comprising a wheel (5) rotatably mounted on the barrel (1) and to which the trailing end of the writing unit (8) is connected by a pivot having its axis spaced from the rotation axis. In the writing position of the writing tip (9), the wheel abuts a stop defined either by the writing unit or the barrel to support the writing pressure exerted against the writing tip. The rear end of the reservoir tube (10) can be formed for direct snap-fit connection to the wheel, and the wheel is a snap-fit in the barrel.Type: GrantFiled: February 22, 1989Date of Patent: April 17, 1990Assignee: The Gillette CompanyInventors: Robert White, Michael B. Seal