Patents by Inventor Michael B. SHAGHAFI

Michael B. SHAGHAFI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAGL INHIBITORS
    Publication number: 20240018120
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 18, 2024
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20230357190
    Abstract: Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: Thomas VETTER, John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • MAGL inhibitors
    Patent number: 11691975
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: July 4, 2023
    Assignee: H. LUNDBECKA/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • TARGETED AUTOPHAGY CONJUGATES AND METHODS
    Publication number: 20220387411
    Abstract: Provided herein are methods and compounds for targeted autophagy.
    Type: Application
    Filed: September 23, 2020
    Publication date: December 8, 2022
    Inventors: Michael B. SHAGHAFI, Johannes HERMANN
  • MAGL inhibitors
    Patent number: 11434222
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: September 6, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: John J. M. Wiener, Cheryl A. Grice, Daniel J. Buzard, Justin S. Cisar, Olivia Delene Weber, Amy Allan, Nicholas Raffaele, Jeanne Moody, Michael B. Shaghafi
  • MAGL INHIBITORS
    Publication number: 20220153721
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 11, 2021
    Publication date: May 19, 2022
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne MOODY, Michael B. SHAGHAFI
  • MAGL inhibitors
    Patent number: 11332453
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 17, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • MAGL INHIBITORS
    Publication number: 20220135563
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: June 9, 2021
    Publication date: May 5, 2022
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • MAGL inhibitors
    Patent number: 11214557
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: January 4, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • Spirocycle compounds and methods of making and using same
    Patent number: 11161856
    Abstract: Provided herein are compounds of the formula: and compositions comprising the same, which are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: November 2, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi
  • Pyrazole MAGL inhibitors
    Patent number: 11149037
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 19, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi, John J. M. Wiener, Justin S. Cisar, Katharine K. Duncan
  • Spirocycle compounds and methods of making and using same
    Patent number: 11142526
    Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 12, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi, Todd K. Jones
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210214375
    Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: August 28, 2018
    Publication date: July 15, 2021
    Inventors: Cheryl A. GRICE, Olivia D. WEBER, Daniel J. BUZARD, Michael B. SHAGHAFI
  • MAGL inhibitors
    Patent number: 11059822
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: July 13, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
  • MAGL INHIBITORS
    Publication number: 20210206735
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 14, 2019
    Publication date: July 8, 2021
    Applicant: Lundbeck La Jolla Research Center, Inc.
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20210147367
    Abstract: Described herein is new crystalline forms of the MAGL inhibitor 2-(2-((4-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)carbonyl)piperazin-1-yl)methyl)-5-(trifluoromethyl)phenoxy)-2-methylpropanoic acid, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 12, 2020
    Publication date: May 20, 2021
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI, Nicole S. WHITE, Heidi LOPEZ DE DIEGO, Frans Dennis THERKELSEN, Ida Marie Brødsgaard KNUDSEN
  • Piperazine carbamates and methods of making and using same
    Patent number: 10899737
    Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: January 26, 2021
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi, Olivia D. Weber
  • Spirocycle compounds and methods of making and using same
    Patent number: 10781211
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 22, 2020
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Daniel J. Buzard, Michael B. Shaghafi, Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber
  • MAGL INHIBITORS
    Publication number: 20200291023
    Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: November 15, 2017
    Publication date: September 17, 2020
    Inventors: Cheryl A. GRICE, Daniel J. BUZARD, Michael B. SHAGHAFI
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200255427
    Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: August 28, 2018
    Publication date: August 13, 2020
    Inventors: Cheryl A. GRICE, Olivia D. WEBER, Daniel J. BUZARD, Michael B. SHAGHAFI, Todd K. JONES