Patents by Inventor Michael B. Simmers

Michael B. Simmers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20220298487
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: April 26, 2021
    Publication date: September 22, 2022
    Inventors: Brian R. WAMHOFF, Brett R. BLACKMAN, Robert A. FIGLER, Daniel G. GIOELI, Michael B. SIMMERS
  • In vitro model for pathological or physiologic conditions
    Patent number: 11061016
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: July 13, 2021
    Assignee: HemoShear, LLC
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • IN VITRO MODEL FOR PATHOLOGICAL OR PHYSIOLOGIC CONDITIONS
    Publication number: 20210172935
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Application
    Filed: October 1, 2020
    Publication date: June 10, 2021
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • In vitro model for a tumor microenvironment
    Patent number: 11008549
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: May 18, 2021
    Assignee: Hemoshear, LLC
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • In vitro model for pathological or physiologic conditions
    Patent number: 10837957
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: November 17, 2020
    Assignee: HemoShear, LLC
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • IN VITRO MODEL FOR PATHOLOGICAL OR PHYSIOLOGIC CONDITIONS
    Publication number: 20200326329
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Application
    Filed: December 18, 2019
    Publication date: October 15, 2020
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20200010809
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: February 22, 2019
    Publication date: January 9, 2020
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • In vitro model for pathological or physiologic conditions
    Patent number: 10514374
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: December 24, 2019
    Assignee: HemoShear, LLC
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • In vitro model for a tumor microenvironment
    Patent number: 10221394
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: March 5, 2019
    Assignee: HemoShear, LLC
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • IN VITRO MODEL FOR PATHOLOGICAL OR PHYSIOLOGIC CONDITIONS
    Publication number: 20180045714
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Application
    Filed: May 19, 2017
    Publication date: February 15, 2018
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20180016557
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: April 10, 2017
    Publication date: January 18, 2018
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • IN VITRO MODEL FOR PATHOLOGICAL OR PHYSIOLOGIC CONDITIONS
    Publication number: 20170227527
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Application
    Filed: November 18, 2016
    Publication date: August 10, 2017
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • In vitro model for pathological or physiologic conditions
    Patent number: 9658211
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: May 23, 2017
    Assignee: HemoShear, LLC
    Inventors: Brett R. Blackman, Brian R. Warnhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • In vitro model for a tumor microenvironment
    Patent number: 9617521
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: April 11, 2017
    Assignee: HemoShear, LLC
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • In vitro model for pathological or physiologic conditions
    Patent number: 9500642
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: November 22, 2016
    Assignee: Hemoshear, LLC
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • IN VITRO MODEL FOR PATHOLOGICAL OR PHYSIOLOGIC CONDITIONS
    Publication number: 20150362483
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Application
    Filed: April 18, 2013
    Publication date: December 17, 2015
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • IN VITRO MODEL FOR A TUMOR MICROENVIRONMENT
    Publication number: 20150111240
    Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 23, 2015
    Inventors: Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
  • IN VITRO MODEL FOR PATHOLOGICAL OR PHYSIOLOGIC CONDITIONS
    Publication number: 20130309677
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Application
    Filed: April 18, 2013
    Publication date: November 21, 2013
    Applicant: HemoShear, LLC
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver