Patents by Inventor Michael B. Wallace

Michael B. Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KINASE INHIBITORS
    Publication number: 20100120717
    Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture in comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: October 8, 2007
    Publication date: May 13, 2010
    Inventors: Jason W. Brown, Qing Dong, Bheema R. Paraselli, Jeffrey A. Stafford, Michael B. Wallace, Hasanthi Wijesekera
  • Kinase inhibitors
    Patent number: 7713973
    Abstract: Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: May 11, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Qing Dong, David J. Hosfield, Bheema R. Paraselli, Nicholas Scorah, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7687638
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound of the formula: wherein the substituents are as defined herein.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: March 30, 2010
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Michael B. Wallace, Zhlyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7687625
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C?NR9; and R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: March 30, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • cMET INHIBITORS
    Publication number: 20100063054
    Abstract: Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: August 14, 2009
    Publication date: March 11, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Jerome C. Bressi, Shaosong Chu, Philip Erickson, Mallareddy Komandla, Lily Kwok, John D. Lawson, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang, Sanjib Das
  • PREPARATION OF (R)-3-AMINOPIPERIDINE DIHYDROCHLORIDE
    Publication number: 20100029941
    Abstract: Described herein are methods for making chiral derivatives of 3-aminopiperidine, including the production of such derivatives in quantities exceeding 1 kilogram. The chiral 3-aminopiperidine derivatives include (R)-3-aminopiperidine derivatives which may be used to synthesize inhibitors of Dipeptidyl Peptidase IV. (R)-3-Aminopiperidine dihydrochloride is prepared by reducing (R)-3-aminopiperidin-2-one hydrochloride with lithium aluminum hydride. The preparation of (R)-3-aminopiperidin-2-one hydrochloride starting from (R)-methyl-2,5-diaminopentanoate dihydrochloride or (R)-2,5-diaminopentanoic acid hydrochloride is also described.
    Type: Application
    Filed: March 26, 2007
    Publication date: February 4, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Michael B. Wallace, Jeremy Cody, Richard S. Fornicola, Silvina Garcia-Rubio, Philip B. Kisanga, Maxwell D. Reeve, Chandra Wilson
  • Dipeptidyl peptidase inhibitors
    Patent number: 7638638
    Abstract: Pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound with the formula: where the labeled substituents are as described herein.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: December 29, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Michael B. Wallace, Xiao-Yi Xiao, Zhiyuan Zhang
  • KINASE INHIBITORS
    Publication number: 20090247554
    Abstract: Compounds are provided for use with kinases that comprise (I), (II), (III), (IV): wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: March 27, 2007
    Publication date: October 1, 2009
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Qing Dong, Michael B. Wallace
  • Dipeptidyl peptidase inhibitors
    Patent number: 7579357
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: August 25, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhlyuan Zhang
  • Dipeptidyl peptidase inhibitors
    Patent number: 7550590
    Abstract: Compounds, pharmaceuticals, kits, and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C?NR9; and R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: June 23, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • KINASE INHIBITORS
    Publication number: 20090156557
    Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: April 15, 2008
    Publication date: June 18, 2009
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Jason W. Brown, Qing Dong, Bheema R. Paraselli, Jeffrey A. Stafford, Xianchang Gong, Yan Liu, Nicholas Scorah, Michael B. Wallace
  • MAPK/ERK KINASE INHIBITORS
    Publication number: 20090124595
    Abstract: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: November 7, 2008
    Publication date: May 14, 2009
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: MarK Adams, Qing Dong, Toufike Kanouni, Stephen W. Kaldor, Nicholas Scorah, Michael B. Wallace
  • MAPK/ERK KINASE INHIBITORS
    Publication number: 20090118324
    Abstract: Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: March 17, 2008
    Publication date: May 7, 2009
    Inventors: Qing DONG, Toufiko Kanounl, Michael B. Wallace
  • Dipeptidyl peptidase inhibitors
    Patent number: 7470700
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: December 30, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, II, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang
  • MAPK/ERK KINASE INHIBITORS
    Publication number: 20080312307
    Abstract: Compounds are provided for inhibition of MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: May 23, 2008
    Publication date: December 18, 2008
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Mark E. Adams, Qing Dong, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace
  • MAPK/ERK KINASE INHIBITORS
    Publication number: 20080255160
    Abstract: Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: December 18, 2007
    Publication date: October 16, 2008
    Inventors: Qing Dong, Xianchang Gong, Stephen W. Kaldor, Toufike Kanouni, Nicholas Scorah, Michael B. Wallace, Feng Zhou
  • MAPK/ERK KINASE INHIBITORS
    Publication number: 20080188453
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 7, 2008
    Inventors: Mark E. Adams, Qing Dong, Stephen W. Kaldor, Toulik Kanouri, Michael B. Wallace
  • Probe, assay and kits for detecting 11?-hydroxysteroid dehydrogenase and modulators thereof
    Patent number: 7235672
    Abstract: A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises: wherein DM is a detectable marker; and L is a straight or branched chain moiety providing between 1 and 20 atom separation between DM and the ring atom to which DM is attached.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 26, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Christopher L. Caster, Andrew J. Jennings, Marc E. Navre, Michael B. Wallace, Yiqin Wu
  • Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
    Patent number: 6919461
    Abstract: Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: July 19, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Siegfried Heinz Reich, Ted Michael Bleckman, Susan Elizabeth Kephart, William Henry Romines, Michael B. Wallace
  • Dipeptidyl peptidase inhibitors
    Publication number: 20040259870
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: 1
    Type: Application
    Filed: March 24, 2004
    Publication date: December 23, 2004
    Applicant: Syrrx, Inc.
    Inventors: Jun Feng, Stephen L. Gwaltney, Stephen W. Kaldor, Jeffrey A. Stafford, Michael B. Wallace, Zhiyuan Zhang