Abstract: Disclosed herein is a nanocomposite comprising a core-shell nanoparticle and a core-shell quantum dot. The core-shell nanoparticle comprises a phosphor core, a shell layer, and a cleavable peptide. The core-shell quantum dot comprises a center core, an intermediate layer, an outer layer, a silica layer, and an arginylglycylaspartic acid (RGD) peptide. The core-shell nanoparticle and the core-shell quantum dot are linked to each other via forming a peptide bond between the cleavable peptide and the RGD peptide. Also disclosed are the uses of the nanocomposite in making a diagnosis of tumors.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: An autonomous vehicle configured to autonomously pass a cyclist includes an imaging device and processing circuitry configured to receive information from the imaging device. Additionally, the processing circuitry of the autonomous vehicle is configured to identify a cyclist passing situation based on the information received from the imaging device, and plan a path of an autonomous vehicle based on the cyclist passing situation. The autonomous vehicle also includes a positioning system and the processing circuitry is further configured to receive information from the positioning system, determine if the cyclist passing situation is sufficiently identified, and identify the cyclist passing situation based on the information from the imaging device and the positioning system when the cyclist passing situation is not sufficiently identified based on the information received from the imaging device.

Abstract: Fibrous structures containing filaments and solid additives, and more particularly to fibrous structures containing filaments and solid additives wherein the fibrous structure has three or more regions that exhibit different characteristics and/or properties and methods for making same, are provided.

Abstract: A method of transferring a facial expression from a subject to a computer generated character that includes receiving a plate with an image of the subject's facial expression, a three-dimensional parameterized deformable model of the subject's face where different facial expressions of the subject can be obtained by varying values of the model parameters, a model of a camera rig used to capture the plate, and a virtual lighting model that estimates lighting conditions when the image on the plate was captured.

Abstract: A method of transferring a facial expression from a subject to a computer generated character that includes receiving a plate with an image of the subject's facial expression, a three-dimensional parameterized deformable model of the subject's face where different facial expressions of the subject can be obtained by varying values of the model parameters, a model of a camera rig used to capture the plate, and a virtual lighting model that estimates lighting conditions when the image on the plate was captured.