Abstract: Described herein are method of generating and uses of polypeptides with dual binding specificity, wherein the polypeptides contain a first binding-site for a first antigen and a second binding-site for a second antigen. The second binding-site comprises amino acid variants of native amino acid sequences of polypeptides that bind to the first antigen, wherein the variants do not abrogate binding to said first antigen. In one embodiment, polypeptides with dual binding specificity to PD1 and OX40 are disclosed herein. In another embodiment, polypeptides with dual binding specificity to PD1 and GITR are disclosed herein.

Abstract: Described herein are engineered anti-IL-2 antibodies with modified amino acid sequences. The engineered antibodies would confer modified receptor binding specificity to an IL-2-anti-IL2 antibody complex, inhibiting the binding of IL-2 to CD25. The engineered anti-IL-2 antibodies would facilitate expansion of subsets of effector immune cells and decrease undesirable effects caused by IL-2. Thus, the engineered anti-IL-2 antibodies would be useful in treating disease such as cancer and infection.

Abstract: Systems and methods to ensure the safety of pets when using a leash and collar assembly are provided. Embodiments of such systems and methods may be mechanical and/or electro-mechanical devices that allow for the safe decoupling of a pet when potentially injurious forces are applied to the leash and collar assembly. In preferred embodiments, such decoupling or release is substantially automatic based on a set of predefined jeopardy conditions.

Abstract: A tubular motor including a driving systen and a winch mechanism enclosed within a common tubular housing, the driving system including a DC motor and a unitary power supply, the unitary power supply being electrically connectable to an AC electricity source external to the housing and to the DC motor within the housing, and being adapted to convert AC electricity supplied by the AC electricity source into low voltage direct current electricity suitable for the DC motor, by transformation and rectification. The winch mechanism is coupled to and driven by the DC motor.