Abstract: The present application discloses granules with a solid core that is coated with a cellulosic polymer. The solid core of the granules can be made of a number of active ingredients. The granules can be used in animal feeds to deliver the active ingredients into the intestine of animals for maximum effect.

Abstract: Techniques for modifying data within a virtual space are discussed herein. A communication platform may receive a request from a user profile associated with a virtual space. The request may include instruction(s) for the communication platform to perform a modifying operation on data within a virtual space. Based on receiving the request, the communication platform may identify the data on which the operation is to be performed. The communication platform may input the data to one or more machine-learning models trained to output data that is a modified version of the data input to the machine-learning model (e.g., modified data). In such cases, the modified data may be modified consistent with the requested operation. The communication platform may receive the modified data from the machine-learning model and cause the modified data to be displayed via a user interface associated with the user profile.

Abstract: Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

Abstract: A system receives identification of an item to be loaded into a vehicle and determines dimensions of the item. The system adds the item to a total load for an identified vehicle and, based on known dimensions of available space in the identified vehicle, determines one or more candidate placement options for each of one or more items comprising the total load, within available space within the vehicle, wherein candidate placement options for each item are determined so as not to overlap with placement options for another of the one or more items within a given configuration representing placement options for all of the one or more items comprising the total load. Additionally, the system presents a visual rendering of at least one given configuration that successfully allows the total load to fit within the available space.

Abstract: A system includes one or more processors configured to determine that a vehicle is attempting to enter an area designated for off-road travel. The processors are also configured to access use-restrictions stored in a database and associated with the area, the use-restrictions defining at least one vehicle constraint required for the vehicle to travel over one or more locations that are part of the area, the use restrictions defining at least one of vehicle control limiting or vehicle weight maximums. The processors are further configured to determine whether the vehicle meets the use-restrictions based on an assessment of vehicle characteristics compared to the use-restrictions and responsive to determining that the vehicle meets the restrictions, providing the vehicle with a digital access pass to the area.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: Virtual auditory display devices are described. An example virtual auditory display device comprises a first and a second ear-worn device, each of which include an acoustic package, an ear interface having multiple cavities, and an electronics package. The acoustic package may be positioned at least partially within the ear interface cavities and includes a housing, a connector including a set of annular electrical contacts, and one or more speakers positioned within the housing that are configured to emit sound based on signals received by the set of annular electrical contacts. The electronics package is removably coupleable to the acoustic package and includes a set of electrical connectors configured to connect with the set of annular electrical contacts and electronics configured to receive audio signals, generate the signals based on the audio signals, and provide the signals to the set of annular electrical contacts via the set of electrical connectors.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for robot motion planning using unmanned aerial vehicles (UAVs). One of the methods includes determining that a current plan for performing a particular task with a robot requires modification; in response, generating one or more flight plans for an unmanned aerial vehicle (UAV) based on a robotic operating environment comprising the robot; obtaining, using the UAV in accordance with the one or more flight plans, a new measurement of the robotic operating environment comprising the robot; and generating, based at least on a difference between the new measurement of the robotic operating environment and a previous measurement of the robotic operating environment, a modified plan for performing the particular task with the robot.

Abstract: A guard for a space access device is configured to output air flow through a distal end portion thereof. The guard includes q housing having a proximal end opening, a distal end opening, and a filter portion positioned between the proximal and distal end openings. The filter includes a first plate having a first opening therethrough and a second plate having a second opening therethrough. When the first plate is overlaid in contact with the second plate, this forms an aperture that extends through both the first and second plates.

Abstract: Embodiments include, for example, mechanical release systems for implantable medical devices.

Abstract: Embodiments include, for example, mechanical release systems for implantable medical devices.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Abstract: Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.

Abstract: Techniques to facilitate prevention of malicious attacks on a web service are disclosed herein. In at least one implementation, a computing system intercepts a web request directed to a web server providing the web service. The computing system identifies whether or not the web request is malicious. When the web request is identified as malicious, the computing system redirects the web request to an isolated mitigation server configured to mimic responses of the web server. The isolated mitigation server processes the web request to generate artificial content based on the web request that appears to be genuine content provided by the web server, and presents the artificial content in response to the web request.

Abstract: Embodiments include, for example, mechanical release systems for implantable medical devices.