Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: This disclosure is generally directed to systems and methods related to providing assistance services to a disabled vehicle. In an example embodiment, a method executed by a first processor in a vehicle may involve detecting an event that places the vehicle in a disabled condition; transmitting information associated with the event to a second processor; and detecting an arrival of a assistance vehicle that is dispatched by the second processor based on an automated evaluation of the information associated with the event. The second processor, which can be, for example, a part of a server computer, may evaluate the information in order to identify an assistance vehicle having equipment for providing the assistance service. In an example scenario, the disabled vehicle and/or the assistance vehicle can be an autonomous vehicle.

Abstract: Use of a satellite network as a source of image data for detection of off-road obstacles is provided. Image data from a satellite network is received to an OBU of a vehicle via a transceiver of the vehicle. The image data is related to an off-road location to be traversed by the vehicle. A navigation map indicating locations of any obstacles detected as being present based on an analysis of changes in the image data over time is displayed in an HMI of the vehicle.

Abstract: A network appliance receives a network packet and determines an application identifier for the network packet. Key specification fetching circuits in the processing stages of the network appliance's match-action pipelines can use the application identifiers to read key specifications. The key specifications are stored in memory and may be cached near the processing stages. Key construction circuits in the processing stages can use the key specifications to construct keys. The processing stages can process the network based on the keys because the keys may be used to obtain action indicators from match-action tables. As such, the processing stages can construct and use keys that may be dynamically defined by storing their key specifications in memory.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for robot motion planning using unmanned aerial vehicles (UAVs). One of the methods includes determining that a current plan for performing a particular task with a robot requires modification; in response, generating one or more flight plans for an unmanned aerial vehicle (UAV) based on a robotic operating environment comprising the robot; obtaining, using the UAV in accordance with the one or more flight plans, a new measurement of the robotic operating environment comprising the robot; and generating, based at least on a difference between the new measurement of the robotic operating environment and a previous measurement of the robotic operating environment, a modified plan for performing the particular task with the robot.

Abstract: A guard for a space access device is configured to output air flow through a distal end portion thereof. The guard includes q housing having a proximal end opening, a distal end opening, and a filter portion positioned between the proximal and distal end openings. The filter includes a first plate having a first opening therethrough and a second plate having a second opening therethrough. When the first plate is overlaid in contact with the second plate, this forms an aperture that extends through both the first and second plates.

Abstract: Embodiments include, for example, mechanical release systems for implantable medical devices.

Abstract: Embodiments include, for example, mechanical release systems for implantable medical devices.

Abstract: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Abstract: A CMOS-based chip having one or more sensing modalities that are able independently to detect multiple metabolites present in a biological sample. The multiple sensing modalities may be provided at different locations with respect to the chip, whereby the chip can simultaneously detect a plurality of metabolites by measuring behaviour of a test material in the different locations. The chip may utilise paper as a transport mechanism for the sample. The paper either conveys the sample to the different locations or itself provides discrete testing zones in which different metabolites can be independently detected. With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.

Abstract: Systems, methods, and apparatuses are described for verifying the authenticity of an integrated circuit device. An integrated test apparatus may use quiescent current and/or conducted electromagnetic interference readings to determine if a device under test matches the characteristics of an authenticated device. Deviations from the characteristics of the authenticated device may be indicative of a counterfeit device.

Abstract: Techniques to facilitate prevention of malicious attacks on a web service are disclosed herein. In at least one implementation, a computing system intercepts a web request directed to a web server providing the web service. The computing system identifies whether or not the web request is malicious. When the web request is identified as malicious, the computing system redirects the web request to an isolated mitigation server configured to mimic responses of the web server. The isolated mitigation server processes the web request to generate artificial content based on the web request that appears to be genuine content provided by the web server, and presents the artificial content in response to the web request.

Abstract: Embodiments include, for example, mechanical release systems for implantable medical devices.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for robot motion planning using unmanned aerial vehicles (UAVs). One of the methods includes determining that a current plan for performing a particular task with a robot requires modification; in response, generating one or more flight plans for an unmanned aerial vehicle (UAV) based on a robotic operating environment comprising the robot; obtaining, using the UAV in accordance with the one or more flight plans, a new measurement of the robotic operating environment comprising the robot; and generating, based at least on a difference between the new measurement of the robotic operating environment and a previous measurement of the robotic operating environment, a modified plan for performing the particular task with the robot.

Abstract: A guard for a space access device is configured to output air flow through a distal end portion thereof. The guard includes q housing having a proximal end opening, a distal end opening, and a filter portion positioned between the proximal and distal end openings. The filter includes a first plate having a first opening therethrough and a second plate having a second opening therethrough. When the first plate is overlaid in contact with the second plate, this forms an aperture that extends through both the first and second plates.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a mobile robotic frame system. In some implementations, a mobile robot includes a motorized frame that is configured to travel to a location. The mobile robot includes a positioning assembly coupled to the motorized frame, a robotic arm having a manipulator, and sensors coupled to the motorized frame. A control system is configured to process data from the sensors and, based on the data from the sensors, provide control data to (i) move the motorized frame, (ii) adjust one or more movable components of the positioning assembly, and (ii) move the robotic arm relative to the motorized frame. The one or more movable components and the robotic arm are operable to position the manipulator at any position in a three-dimensional work volume with 6 degrees of freedom while the motorized frame remains at the location.

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.