Abstract: A spark ignited engine is disclosed. The spark ignited engine includes a main combustion chamber and a cylinder head at least partially surrounding the main combustion chamber. A spark plug having a central axis is arranged in the cylinder head and an ignition end of the spark plug faces the main combustion engine. A pre-chamber with at least two nozzles is arranged in the main combustion chamber and connects the ignition end and the main combustion chamber via the at least two nozzles. A pre-chamber volume ratio corresponds to a ratio of a volume of the pre-chamber to a volume of the main combustion chamber at a top-dead-center and is between 1.9% and 3.1%. A nozzle factor corresponds to a ratio of a summed flowed-through area of the at least two nozzles to the volume of the pre-chamber and is between 0.085 l/cm and 1.15 l/cm.

Abstract: A medical patch can comprise a biocompatible substrate and a dry hydrogel precursor layer on the substrate, the dry hydrogel precursor layer comprising an electrophilic-hydrogel precursor having a plurality of electrophilic functional groups and a nucleophilic-hydrogel precursor having a plurality of protonated amine groups and no more than about 2 weight percent water. Both the electrophilic-hydrogel precursor and the nucleophilic-hydrogel precursor are substantially uncrosslinked, and are blended or in direct contact with each other. The medical patches can be formed by coating a melt blend of hydrogel precursors in a dry environment or based on solution coating from a dry, non-aqueous solvent, onto a porous, hydrophilic substrate. The medical patches can be used for placement over a bleeding wound or the like and may function as a hemostatic patch. Shredded patches and compositions mimicking a shredded patch can be placed into a wound defect.

Abstract: Compositions, methods, and applications for single component systems for the formation of in situ hydrogels are described. The single component systems are effective for forming stable, single solutions containing precursors providing both electrophilic and nucleophilic groups that chemically crosslink on contact with physiological fluids associated with vital physiological tissue. The single component systems can be applied using various delivery vehicles, including injections, needle and needless catheters, and sprays. The single component systems can be useful for enabling multiple injections from a single syringe through a small gauge needle or other dispenser. Methods for transcervical installation of in situ formed hydrogels into one or more fallopian tubes are described.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Polymers may be entrapped in pores of materials to provide a durable modification of the materials.

Abstract: A spark ignited engine is disclosed. The spark ignited engine includes a main combustion chamber and a cylinder head at least partially surrounding the main combustion chamber. A spark plug having a central axis is arranged in the cylinder head and an ignition end of the spark plug faces the main combustion engine. A pre-chamber with at least two nozzles is arranged in the main combustion chamber and connects the ignition end and the main combustion chamber via the at least two nozzles. A pre-chamber volume ratio corresponds to a ratio of a volume of the pre-chamber to a volume of the main combustion chamber at a top-dead-center and is between 1.9% and 3.1%. A nozzle factor corresponds to a ratio of a summed flowed-through area of the at least two nozzles to the volume of the pre-chamber and is between 0.085 l/cm and 1.15 l/cm.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Polymers may be entrapped in pores of materials to provide a durable modification of the materials.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: Medical hydrogel systems for providing improved properties for certain medical applications are described. The hydrogel systems are effective for forming a space filling hydrogel in a body cavity and for the prevention of adhesion formation between tissues within the body cavity following a surgical procedure. Hydrogel delivery systems for transcervical delivery of a premixed precursor solution and an accelerator solution are described. Methods for transcervical installation of intrauterine hydrogels with distended fill are also described. The hydrogel systems, hydrogel delivery systems, and associated methods can be useful for providing degradable hydrogel in the uterine cavity, including the cervical canal, for the prevention of adhesions following intrauterine procedures.

Abstract: Transcervical access systems for providing transcervical movement of fluids are described. The transcervical access systems are effective for transferring a broad range of fluids, including the delivery of hydrogel precursors, saline, and imaging fluids, to the uterine cavity. The transcervical access systems are also effective for removing fluids from the uterine cavity, such as residual bodily fluids, residual fluids from a procedure, or tissue. The transcervical access systems described include flow limiters, such as egress limiters and/or cervical plugs. Methods of use of the transcervical access systems are also described. Methods include using the transcervical access systems to transcervical access the uterine cavity and install hydrogel. The transcervical access systems and associated methods can be useful for providing degradable hydrogel in the uterine cavity, including the cervical canal, for the prevention of adhesions following intrauterine procedures.

Abstract: Articles, such as catheters, comprising markings and associated methods are generally provided. The articles described herein may be configured to be exhibit one or more desirable properties. For instance, in some embodiments, an article comprises markings that are spaced from each other at known distances. Such markings may be employed to aid users of the article in measuring distances. As another example, an article may be configured to swell upon exposure to the fluid such that markings positioned thereon do not crack or delaminate. It is also possible for the article to be configured to swell upon exposure to the fluid in a known, predictable, and/or uniform manner. This swelling may cause the spacings between the markings to increase, and such increase may also be in a known, predictable, and/or uniform manner.

Abstract: A prosthesis comprising a water-dissolvable coating. A prosthesis for a lacrimal canaliculus comprising a swellable punctal plug with a proximal end and a distal end, with the plug comprising a water-dissolvable biocompatible coating on the distal and/or the proximal end. Materials and methods for making and using the same. A prosthesis for placement in or across natural or prosthetic lumens, ostia, ducts, sinus, or sphincters, the prosthesis comprising a coating. The prosthesis can further provide a depot for sustained drug delivery to tissue.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces. Biologically active agents may be entrapped in pores of materials to provide a controlled release of the biologically active agent.

Abstract: A prosthesis comprising a water-dissolvable coating. A prosthesis for a lacrimal canaliculus comprising a swellable punctal plug with a proximal end and a distal end, with the plug comprising a water-dissolvable biocompatible coating on the distal and/or the proximal end. Materials and methods for making and using the same. A prosthesis for placement in or across natural or prosthetic lumens, ostia, ducts, sinus, or sphincters, the prosthesis comprising a coating. The prosthesis can further provide a depot for sustained drug delivery to tissue.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.

Abstract: Configurations are provided for vehicular robots or other vehicles to provide shifting of their centers of gravity for enhanced obstacle navigation. Various head and neck morphologies are provided to allow positioning for various poses such as a stowed pose, observation poses, and inspection poses. Neck extension and actuator module designs are provided to implement various head and neck morphologies. Robot control network circuitry is also provided.