Patents by Inventor MICHAEL BEASE

MICHAEL BEASE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS
    Publication number: 20200392145
    Abstract: The present invention provides a process for the preparation of a compound of formula (2): the process comprising reacting a compound of formula (1), a base and an alkylating agent R4—X in a nitrile-containing polar aprotic solvent to form the compound of formula (2), wherein the process is carried out at a temperature greater than 60° C.; and wherein R1, R2, R3, R4, and X are as defined in the specification.
    Type: Application
    Filed: January 18, 2018
    Publication date: December 17, 2020
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Nicolas ARCHER, Michael BEASE, Rebecca FISHER, Susan ANDREWS
  • Method of preparing buprenorphine
    Patent number: 10208054
    Abstract: An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: February 19, 2019
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Nicolas Archer, David August, Michael Bease, Barbara Jamieson, Robert S. Marmor
  • METHOD OF PREPARING BUPRENORPHINE
    Publication number: 20170217978
    Abstract: An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.
    Type: Application
    Filed: April 17, 2017
    Publication date: August 3, 2017
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Nicolas ARCHER, David AUGUST, Michael BEASE, Barbara JAMIESON, Robert S. MARMOR
  • Method of preparing buprenorphine
    Patent number: 9624231
    Abstract: An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: April 18, 2017
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Nicolas Archer, David August, Michael Bease, Barbara Jamieson, Robert S. Marmor
  • Process
    Patent number: 8916707
    Abstract: The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6?-oxycodol in an amount ?about 0.800 area % as determined by HPLC.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: December 23, 2014
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Nicolas Archer, Maureen Young, Timothy Davies, Amy Price, Michael Bease, Barbara Jamieson, Ewart Grant, Brian Heinrich, Saroop Matharu
  • METHOD OF PREPARING BUPRENORPHINE
    Publication number: 20140235860
    Abstract: An improved process for preparing buprenorphine and a method for increasing the yield of buprenorphine or a derivative thereof.
    Type: Application
    Filed: October 1, 2012
    Publication date: August 21, 2014
    Applicant: JOHNSON MATTEY PUBLIC LIMITED COMPANY
    Inventors: Nicolas Archer, David August, Michael Bease, Barbara Jamieson, Robert S. Marmor
  • PROCESS
    Publication number: 20140045876
    Abstract: The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6?-oxycodol in an amount ?about 0.800 area % as determined by HPLC.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 13, 2014
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: NICOLAS ARCHER, MAUREEN YOUNG, TIMOTHY DAVIES, AMY PRICE, MICHAEL BEASE, BARBARA JAMIESON, EWART GRANT, BRIAN HEINRICH, SAROOP MATHARU