Abstract: Described herein are RPE cells engineered to secrete a FVII protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating a patient with hemophilia or FVII deficiency.

Abstract: Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid.

Abstract: Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

Abstract: Described herein are implantable devices comprising means for mitigating the foreign body response (FBR) and at least one cell-containing compartment which comprises a plurality of cells (e.g., live cells) encapsulated in a polymer composition comprising a cell-binding substance (CBS), as well as compositions and methods of making and using the same. The cells are capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

Abstract: Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

Abstract: Methods for providing remote access to an application executing on a remote server. A client computer includes a client remote access program that is used to connect to a server remote access program. At the client computer, a client difference program having encoded data indicative of changes to the application since changes were last received from the server computer is generated and transmitted to the server remote access program. At the server computer, the client difference program is executed to update the application and a server difference program is generated having encoded changes to the application since the changes were last received from the client computer. The server difference program is transmitted to the client computer to update the application.

Abstract: A method and system for providing remote access to a state of an application is provided. The method comprises executing an application program at a server computer for performing an application associated therewith. At a client computer connected to the server computer via a communication network a remote access program is executed for providing remote access to a state of the performed application. At the client computer a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server computer. At the server computer the client difference program is executed for determining an updated state of the application and a server difference program having encoded a difference between the updated state of the application and the state of the application last sent to the client computer is generated.

Abstract: A method and system for providing remote access to a state of an application executing on a remote server. A client computer includes a client remote access program that is used to connect to a server remote access program. At the client computer, a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server remote access program. At the server computer, the client difference program is executed to update the state of the application and a server difference program is generated having encoded a difference between the updated state of the application and the state of the application last sent to the client computer. The server difference program is transmitted to the client computer to update the state of the application since it was last received from the server computer.

Abstract: A method and system for providing remote access to a state of an application is provided. The method comprises executing an application program at a server computer for performing an application associated therewith. At a client computer connected to the server computer via a communication network a remote access program is executed for providing remote access to a state of the performed application. At the client computer a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server computer. At the server computer the client difference program is executed for determining an updated state of the application and a server difference program having encoded a difference between the updated state of the application and the state of the application last sent to the client computer is generated.

Abstract: A method and system for providing remote access to a state of an application executing on a remote server. A client computer includes a client remote access program that is used to connect to a server remote access program. At the client computer, a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server remote access program. At the server computer, the client difference program is executed to update the state of the application and a server difference program is generated having encoded a difference between the updated state of the application and the state of the application last sent to the client computer. The server difference program is transmitted to the client computer to update the state of the application since it was last received from the server computer.

Abstract: A method and system for providing remote access to a state of an application is provided. The method comprises executing an application program at a server computer for performing an application associated therewith. At a client computer connected to the server computer via a communication network a remote access program is executed for providing remote access to a state of the performed application. At the client computer a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server computer. At the server computer the client difference program is executed for determining an updated state of the application and a server difference program having encoded a difference between the updated state of the application and the state of the application last sent to the client computer is generated.

Abstract: A method and system for providing remote access to a state of an application executing on a remote server. A client computer includes a client remote access program that is used to connect to a server remote access program. At the client computer, a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server remote access program. At the server computer, the client difference program is executed to update the state of the application and a server difference program is generated having encoded a difference between the updated state of the application and the state of the application last sent to the client computer. The server difference program is transmitted to the client computer to update the state of the application since it was last received from the server computer.

Abstract: A method for transmitting image data sets via a communication network is provided. Image data are processed for dividing the image into a plurality of the image sub regions and for determining for each of the plurality of the image sub regions a hash code in dependence upon pixel data of pixels located in the respective image sub region. The hash codes are transmitted together with location data of the respective image sub regions if the hash code exists in an associative dataset and the pixel data are transmitted together with location data of the respective image sub regions if the hash code does not exist in the associative dataset. Upon receipt of at least one of the hash codes and the pixel data together with the location data, image data are generated.

Abstract: A method and system for providing remote access to a state of an application is provided. The method comprises executing an application program at a server computer for performing an application associated therewith. At a client computer connected to the server computer via a communication network a remote access program is executed for providing remote access to a state of the performed application. At the client computer a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server computer. At the server computer the client difference program is executed for determining an updated state of the application and a server difference program having encoded a difference between the updated state of the application and the state of the application last sent to the client computer is generated.

Abstract: A method and system for providing remote access to a state of an application is provided. The method comprises executing an application program at a server computer for performing an application associated therewith. At a client computer connected to the server computer via a communication network a remote access program is executed for providing remote access to a state of the performed application. At the client computer a client difference program having encoded data indicative of a change of a state of the application last received from the server computer is generated and transmitted to the server computer. At the server computer the client difference program is executed for determining an updated state of the application and a server difference program having encoded a difference between the updated state of the application and the state of the application last sent to the client computer is generated.

Abstract: A method and system for accessing a data file is provided. At a server computer a request for accessing a data file of a plurality of data files stored in a database is received. The server computer is connected to the database via a first communication link and a second communication link. Metadata associated with the data file in the database are accessed via the first communication link using a first query protocol. In dependence upon the metadata the data file is located in the database. At least a portion of data stored in the data file is then accessed in the database via the second communication link using a second query protocol.

Abstract: A method for transmitting image data sets via a communication network is provided. Image data are processed for dividing the image into a plurality of image sub regions and for determining for each of the plurality of the image sub regions a hash code in dependence upon pixel data of pixels located in the respective image sub region. The hash codes are transmitted together with location data of the respective image sub regions if the hash code exists in an associative dataset and the pixel data are transmitted together with location data of the respective image sub regions if the hash code does not exist in the associative dataset.

Abstract: Systems and methods for rendering document-based user interface software objects are disclosed. User interface software objects may be represented in a document object model on a first computer system. These objects may then be communicated to a second computer system on which they are similarly rendered through use of a document object model on a second computer system. A document on a first computer system may also be updated to reflect either user input through a user interface software object included in the document, or changes induced by server side logic. The updates may be incrementally communicated to and rendered in a second computer system. Location-neutral user interface software objects may be developed without regard to whether the software object will ultimately reside on a client or server computer system, wherein the user interface software object is equally capable of being supported on either one of a client or server computer system.

Abstract: Systems and methods for rendering document-based user interface software objects are disclosed. User interface software objects may be represented in a document object model on a first computer system. These objects may then be communicated to a second computer system on which they are similarly rendered through use of a document object model on a second computer system. A document on a first computer system may also be updated to reflect either user input through a user interface software object included in the document, or changes induced by server side logic. The updates may be incrementally communicated to and rendered in a second computer system.

Abstract: A method for transmitting image data sets via a communication network is provided. Image data are processed for dividing the image into a plurality of image sub regions and for determining for each of the plurality of the image sub regions a hash code in dependence upon pixel data of pixels located in the respective image sub region. The hash codes are transmitted together with location data of the respective image sub regions if the hash code exists in an associative dataset and the pixel data are transmitted together with location data of the respective image sub regions if the hash code does not exist in the associative dataset.