Patents by Inventor Michael Bech Jensen

Michael Bech Jensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220054604
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: April 15, 2021
    Publication date: February 24, 2022
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt
  • Publication number: 20200254072
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: April 30, 2020
    Publication date: August 13, 2020
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20200046812
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 13, 2020
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt
  • Publication number: 20190328851
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: July 10, 2019
    Publication date: October 31, 2019
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20190209475
    Abstract: The present invention relates to pharmaceutical formulations, in particular FVIII formulations. The present invention furthermore relates to methods for producing such compositions.
    Type: Application
    Filed: November 3, 2016
    Publication date: July 11, 2019
    Inventors: Thomas Nylandsted Krogh, Michael Bech Jensen, Heidi Westh Bagger
  • Publication number: 20190111118
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 18, 2019
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20180369347
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 27, 2018
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt
  • Publication number: 20180085439
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: November 21, 2017
    Publication date: March 29, 2018
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20170128550
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: January 19, 2017
    Publication date: May 11, 2017
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20160228553
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 11, 2016
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20160101163
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 14, 2016
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt
  • Publication number: 20160000884
    Abstract: The invention is directed to a liquid, aqueous formulation of coagulation Factor VIII, comprising a Factor VIII molecule, a calcium salt in a concentration of more than 10 mM, and a saccharide and/or polyol in a concentration of at least 100 mM, wherein the formulation has a pH from 5.5-7.5. The invention furthermore provides a method for optimising a liquid formulation of coagulation Factor VIII, the method comprising the steps of: (i) Providing one or more liquid formulations comprising Factor VIII to be tested; (ii) Adding a protein denaturant to said liquid formulations, and incubating the resulting solutions for a predetermined period of time; (iii) Analysing the incubated solutions of (ii) for the presence of dissociated Factor VIII; and (iv) Selecting one or more formulation(s) having a desired low level of dissociated Factor VIII.
    Type: Application
    Filed: August 13, 2013
    Publication date: January 7, 2016
    Applicant: NOVO NORDISK A/S
    Inventors: Christian Rischel, Hans Holmegaard Soerensen, Michael Bech Jensen, Thomas Bjerg
  • Publication number: 20150343064
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: August 11, 2015
    Publication date: December 3, 2015
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Patent number: 9186323
    Abstract: The present invention relates to pharmaceutical compositions comprising: (i) at least 10 mg/mL of a Factor VII polypeptide; (ii) a buffering agent suitable for keeping pH in the range of from about 5.0 to about 9.0; (iii) at least one aromatic preservative in a concentration of at least 0.1 mg/mL; and (iv) at least one antioxidant in a concentration of at least 0.1 mg/mL; the composition optionally comprising further components, with the proviso that such further components are not Factor VII polypeptide stabilizing agents selected from (a) metal-containing agents, wherein said metal is selected from the group consisting of first transition series metals of oxidation state +II, except zinc; and (b) stabilizing agents comprising a —C(?N—Z1-R1)-NH—Z2-R2 motif.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: November 17, 2015
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Christian Rischel, Michael Bech Jensen, Anders Dybdal Nielsen
  • Publication number: 20140178356
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: February 21, 2014
    Publication date: June 26, 2014
    Applicant: Novo Nordisk HealthCare AG
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Patent number: 8729022
    Abstract: The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used at room temperature.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 20, 2014
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt
  • Publication number: 20140127181
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Application
    Filed: December 10, 2013
    Publication date: May 8, 2014
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt
  • Patent number: 8658597
    Abstract: The invention relates to chemically as well as physically stable kits and compositions comprising polypeptides, in particular Factor VII or Factor VII-related polypeptides, such that these compositions can be stored, handled and used at room temperature.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: February 25, 2014
    Assignee: Novo Nordisk HealthCare AG
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt
  • Patent number: 8536127
    Abstract: Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formulation of a protein. Also provided are new methods of storing proteinaceous compositions. In one aspect, the stored protein is characterized as having an amino-terminal ?-carboxyglutamic acid (Gla) domain with 9-12 Gla residues.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: September 17, 2013
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Michael Bech Jensen, Birthe Lykkegaard Hansen, Troels Kornfelt, Kirsten Kramer Jakobsen
  • Patent number: 8461116
    Abstract: A liquid aqueous composition comprising (i) a factor VII polypeptide; (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 8.0; (iii) an agent selected from the list of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is at least 15 mM is described.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: June 11, 2013
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Birthe Lykkegaard Hansen, Michael Bech Jensen, Troels Kornfelt