Patents by Inventor Michael Benjamin Sano

Michael Benjamin Sano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230000543
    Abstract: Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.
    Type: Application
    Filed: November 23, 2020
    Publication date: January 5, 2023
    Inventors: Michael Benjamin Sano, Christopher Fesmire, Ross A. Petrella
  • Patent number: 11519877
    Abstract: Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: December 6, 2022
    Assignee: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY
    Inventors: Rafael V. Davalos, Hadi Shafiee, Michael Benjamin Sano, John L. Caldwell
  • Publication number: 20220080192
    Abstract: A method of treatment includes modifying and/or killing cells by changing the cell membrane charging time to make the cells more susceptible to the influence of electric fields. The method may further include inserting one or more electrodes into tissue, acquiring a temperature of the tissue, delivering electrical energy to the tissue by electrical pulses, determining a rate of energy delivery of the electrical energy such that the temperature rises above a first critical temperature but remains below a second critical temperature, and delivering the electrical energy until a specific dose is achieved.
    Type: Application
    Filed: November 29, 2021
    Publication date: March 17, 2022
    Inventors: Michael Benjamin Sano, Christopher Fesmire, Ross A. Petrella
  • Publication number: 20210212753
    Abstract: A method for performing electrothermal therapy (ETT) includes inserting one or more electrodes into a target tissue, inserting one or more temperature sensors into the target tissue, selecting a pulse waveform for a plurality of electrical pulses, and delivering to the target tissue the plurality of electrical pulses having the selected pulse waveform through the one or more electrodes, wherein a delay between ones of the plurality of electrical pulses is selected based on a temperature reading from the one or more temperature sensors.
    Type: Application
    Filed: May 31, 2019
    Publication date: July 15, 2021
    Inventors: Michael Benjamin Sano, Christopher Carl Fesmire
  • Publication number: 20190137446
    Abstract: Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
    Type: Application
    Filed: August 8, 2018
    Publication date: May 9, 2019
    Inventors: Rafael V. Davalos, Hadi Shafiee, Michael Benjamin Sano, John L. Caldwell
  • Patent number: 10078066
    Abstract: Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: September 18, 2018
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Rafael V. Davalos, Hadi Shafiee, Michael Benjamin Sano, John L. Caldwell
  • Publication number: 20100224493
    Abstract: Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 9, 2010
    Applicant: Virginia Tech Intellectual Properties, Inc.
    Inventors: Rafael V. DAVALOS, Hadi Shafiee, Michael Benjamin Sano, John L. Caldwell