Abstract: A unified platform may comprise a combination of independent frameworks that have been integrated and configured to collaboratively operate seamlessly. In some aspects, the unified platform may comprise one or more of an authentication and authorization framework, a dynamic user interface framework, a workflow state management framework, a notification and active data loss and prevention (DLP) engine framework, and an orchestration engine framework. Each of the frameworks included in the unified platform may comprise one or more of the plurality of computing devices executing computer-readable program instructions.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The invention relates to agonistic TrkB binding molecules, methods for improving agonistic TrkB binders, their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Abstract: This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention relates to novel agonistic anti-TrkB antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: A method for operating an internal combustion piston engine, preferably a spark ignition engine, is disclosed. For each combustion chamber at least one intake valve is closed prematurely or belatedly and an exhaust gas recirculation can be carried out. For each combustion chamber at least two intake valves are provided which are opened at least during the exhaust gas recirculation with different maximum strokes.

Abstract: Described herein generally are catheter systems used to deliver cells and other bioactive materials to a target location within the vascular system of the human body, and methods of delivering cells and other bioactive materials to such target locations.

Abstract: Described herein generally are catheter systems used to deliver cells and other bioactive materials to a target location within the vascular system of the human body, and methods of delivering cells and other bioactive materials to such target locations.

Abstract: Antibody complexes including anti-A? antibodies conjugated with a sialic acid-containing molecule show improved bioavailability with no significant adverse effects on binding to amyloid beta.

Abstract: The disclosure is directed to a method to determine oil consumption in an internal combustion engine that does not require extended operation of the engine in the files and is adaptable to be useful at production facilities for testing of sample engines from the line without installation of the engine into a vehicle and operating the vehicle in order to determine oil consumption of the engine during operating conditions.

Abstract: The disclosure is directed to a method to determine oil consumption in an internal combustion engine that does not require extended operation of the engine in the files and is adaptable to be useful at production facilities for testing of sample engines from the line without installation of the engine into a vehicle and operating the vehicle in order to determine oil consumption of the engine during operating conditions.

Abstract: A device (3) for portioning a string of material (2) moving in the conveying direction (F), particularly a string of sausage, into individual sections (2a) of a predetermined length, including at least one portioning tool (18, 18a, 18b, 19, 19a, 19b, 119a, 119b), which is movable in a circular path around an axis in a manner that it can be moved transversely with respect to the conveying direction (F) into the string of material (2) and out of the string of material and follows the movement of the conveying direction (F) in a limited manner. The portioning tool is rotatable on a circular path around a first axis (20, 21) and on a second circular path around a second axis (16), wherein the axes (16, 20, 21) are arranged at a distance with respect to one another and the rotary movements around the first and around the second axis (16, and 20, 21, respectively) are formed in a manner controllable independent of one another.

Abstract: In an engine braking method for a supercharged internal combustion engine, wherein combustion air, which is under boost pressure and is supplied to the cylinders under the control of engine inlet and outlet valves, is compressed in the cylinders and is subsequently discharged into the exhaust tract, engine braking takes place in a two-stroke operating mode.

Abstract: Compounds that include diorgano groups having quaternary carbons and optionally urethane groups, urea groups, or combinations thereof (i.e., polyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.

Abstract: Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.

Abstract: In a method of operating an internal combustion engine in the engine braking mode, wherein an adjustable cross section adjusting means is provided in the exhaust system upstream of the exhaust gas purification device and at least one of the cylinders of the internal combustion engine is provided with a throttle valve, which, in the engine braking mode, is opened so that the cylinder content is discharged directly into the exhaust system during the compression stroke of the piston and at the same time, the cross section adjusting means is moved into a blocking position, whereupon an increased pressure level is generated in the exhaust system, in the event that a characteristic variable which corresponds to the exhaust gas temperature exceeds a given limit value, the cross section adjusting means is briefly opened and subsequently again closed to avoid overheating of the exhaust system.

Abstract: Polyketal polymers, and methods of making and using such polyketal polymers are disclosed herein. The polyketal poylmers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the polyketal polymers are biodegradable.