Abstract: Apparatus and method for designing an optical extender for a vehicle heads up display (HUD). An example vehicle includes a windshield and a HUD system. The HUD system includes an image source to provide a projection image and a main mirror to project the projection image onto the windshield. The image source and the main mirror define a light path. The HUD system also includes an optical extender between the main mirror and the windshield. The optical extender has a multi-polynomial top surface that modifies light in the light path to, when the light in the light path intersects the windshield, create an optical path wherein a virtual image of the projection image is visible from an eyebox defined within a cabin of the vehicle.

Abstract: Apparatus and method for designing an optical extender for a vehicle heads up display (HUD). An example vehicle includes a windshield and a HUD system. The HUD system includes an image source to provide a projection image and a main mirror to project the projection image onto the windshield. The image source and the main mirror define a light path. The HUD system also includes an optical extender between the main mirror and the windshield. The optical extender has a multi-polynomial top surface that modifies light in the light path to, when the light in the light path intersects the windshield, create an optical path wherein a virtual image of the projection image is visible from an eyebox defined within a cabin of the vehicle.

Abstract: This disclosure provides a glioblastoma biomarker profile comprising glioblastoma associated genetic aberrations. The profile is indicative of a cellular and physiological characteristic of a sample from a subject. The disclosure further provides methods for profiling glioblastoma cellular and physiological characteristics including subtype, survival and drug response.

Abstract: Embodiments of the invention provide a low-power, high-gain amplifier for a crystal oscillator. In some embodiments, the oscillator amplifier circuit comprises two NMOS transistors stacked in series with a PMOS transistor. In various embodiments, each of the NMOS transistors is diode-connected through a resistor and has the input signal capacitively coupled onto its control terminal. The stacked amplifier raises the DC level of the amplified oscillatory signal and can support a substantial oscillation amplitude without clipping.

Abstract: A high-performance crystal oscillator providing effective bias resistors with low power consumption and minimal substrate surface area. In various embodiments of the invention, a switched-capacitor resistor is operably coupled to circuit components, such as an oscillation source, a current source, an input buffer, or an amplifier to provide a bias resistance.

Abstract: A high-performance crystal oscillator providing effective bias resistors with low power consumption and minimal substrate surface area. In various embodiments of the invention, a switched-capacitor resistor is operably coupled to circuit components, such as an oscillation source, a current source, an input buffer, or an amplifier to provide a bias resistance.

Abstract: Embodiments of the invention provide a low-power, high-gain amplifier for a crystal oscillator. In some embodiments, the oscillator amplifier circuit comprises two NMOS transistors stacked in series with a PMOS transistor. In various embodiments, each of the NMOS transistors is diode-connected through a resistor and has the input signal capacitively coupled onto its control terminal. The stacked amplifier raises the DC level of the amplified oscillatory signal and can support a substantial oscillation amplitude without clipping.

Abstract: An integrated circuit has an internal oscillator circuit for being connected to an external frequency source such as a crystal or a ceramic resonator. The internal oscillator circuit has an inverting amplifier across the frequency source terminals to establish an oscillation there. One terminal of the frequency source is coupled to one input of the comparator and to a second input of the comparator through a low pass filter. Coupling the output of the low pass filter to the second input of the comparator is for preventing a DC offset from developing between the two inputs of the comparator. The other terminal of the frequency source is coupled to the second input of the comparator through a high pass filter. The high pass filter provides the comparator with a larger voltage differential to increase noise margin. Noise margin is further improved by allowing an increase in hysteresis in the comparator.

Abstract: A reference circuit provides a reference voltage and a reference current that are both temperature and a power supply voltage independent. The reference circuit includes a bandgap reference circuit, a current source, and a resistor. The bandgap reference circuit provides a feedback voltage to control the current source and thereby generate a temperature independent voltage and a PTAT (proportional to absolute temperature) current. A resistor having a positive temperature coefficient is coupled to the feedback controlled current source to provide a CTAT (complementary to absolute temperature) current. The CTAT current is summed directly into the feedback controlled current source to produce a reference current that is substantially constant over a range of temperatures.

Abstract: A programmable capacitor array does not require separate switching transistors because the capacitors themselves have a switchable capacitance, which capacitors are made in the manner of regular N channel transistors with their source/drains connected to each other. When a logic low is applied to the gate, the capacitance is relatively low and the capacitance is what is commonly called parasitic capacitance. The capacitance increases significantly when a logic high is applied to the gate because the logic high has the effect of inverting the channel. Thus, the capacitor array is made of transistors that themselves have switchable capacitance operated so that no separate switching transistors are required. This allows for construction of an array of unit capacitors to achieve monotonic operation and good linearity using conventional manufacturing of N channel transistors while achieving significant area savings and reduced power consumption.

Abstract: Methods for treating an individual having cancer are provided. The method may include administering a cell migration inhibitor and a chemotherapeutic agent to the individual to inhibit migration of cancer cell. Inhibiting cell migration may increase cell division. In this manner, the cell migration inhibitor and the chemotherapeutic agent in combination may have increased efficacy compared to the chemotherapeutic agent alone due to the increased cell division. The cell migration inhibitor may include any of the inhibitors described herein. For example, the cell migration inhibitor may be an organic molecule having a molecular weight of less than about 700, a monoclonal antibody, or a natural product.