Patents by Inventor Michael Bienkowski

Michael Bienkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substrates and Assays for Beta Secretase Activity
    Publication number: 20080090260
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: May 24, 2007
    Publication date: April 17, 2008
    Inventors: Riqiang Yan, Alfredo Tomasselli, Mark Gurney, Thomas Emmons, Michael Bienkowski, Robert Heinrikson
  • Heparanase II, a novel human heparanase paralog
    Publication number: 20050282251
    Abstract: The present invention provides a cDNA encoding a heretofore unknown enzyme termed heparanase II; constructs and recombinant host cells incorporating the cDNA; the heparanase II polypeptide encoded by the gene; antibodies to the polypeptide; and methods of making and using all of the foregoing.
    Type: Application
    Filed: February 14, 2005
    Publication date: December 22, 2005
    Inventors: Robert Heinrikson, Michael Bienkowski
  • Alzheimer's disease secretase, APP substrates thereof, and uses thereof
    Publication number: 20050196398
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cleaves the ?-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: April 5, 2004
    Publication date: September 8, 2005
    Inventors: Mark Gurney, Michael Bienkowski
  • Substrates and assays for beta-secretase
    Publication number: 20050096457
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 16, 2004
    Publication date: May 5, 2005
    Applicant: Pharmacia & Upjohn Company, a Delaware corporation
    Inventors: Riqiang Yan, Alfredo Tomasselli, Mark Gurney, Thomas Emmons, Michael Bienkowski, Robert Heinrikson
  • Alzheimer's disease secretase, app substrates therefor, and uses therefor
    Publication number: 20050080232
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: May 9, 2001
    Publication date: April 14, 2005
    Inventors: Mark Gurney, Michael Bienkowski, Robert Heinrikson, Luis Parodi, Riqiang Yan
  • Alzheimer's disease secretase
    Publication number: 20050026256
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
    Type: Application
    Filed: September 14, 2004
    Publication date: February 3, 2005
    Inventors: Mark Gurney, Michael Bienkowski, Robert Heinrikson, Luis Parodi, Riqiang Yan