Abstract: The present disclosure provides isolated antibodies that specifically bind to human PD-L1, as well as antigen binding fragments of such antibodies, and kits comprising the anti-PD-L1 antibodies or binding fragments and a set of reagents for detecting a complex of the antibody, or antigen binding fragment thereof, bound to human PD-L1. The antibodies and antigen binding fragments of this disclosure are useful for immunohistochemical detection of human PD-L1 expression in tissue samples. Nucleic acid molecules encoding the antibodies and antigen binding fragments of this disclosure, as well as expression vectors and host cells for expression thereof, are also provided.

Abstract: The present disclosure provides isolated antibodies that specifically bind to human PD-L1, as well as antigen binding fragments of such antibodies, and kits comprising the anti-PD-L1 antibodies or binding fragments and a set of reagents for detecting a complex of the antibody, or antigen binding fragment thereof, bound to human PD-L1. The antibodies and antigen binding fragments of this disclosure are useful for immunohistochemical detection of human PD-L1 expression in tissue samples. Nucleic acid molecules encoding the antibodies and antigen binding fragments of this disclosure, as well as expression vectors and host cells for expression thereof, are also provided.

Abstract: Provided are methods for modulating activity of the immune system using agonists or antagonists of a CD200 receptor. Also provided are methods of treatment and diagnosis of immune disorders.

Abstract: The present invention discloses a portable oral irrigator that is made up of a housing, a pump within the housing, a tube adapted to bring liquid to the pump, and an outlet for discharging a pulsating stream of liquid from the pump. The outlet includes a tip adapted for insertion into an oral cavity, and the tube has a first end and a second end, the first end being attached to the housing and the second end being free, thus enabling the second end to be placed by a user in a container of liquid.

Abstract: An electric toothbrush having in its slip-on brush a piston is disclosed, which is set rotating by a motor shaft projecting out of the handle segment. This piston exhibits a lifting cam, by means of which it effects an axial motion relative to the motor shaft in the slip-on brush. This axial motion causes a reciprocating motion of a toothed rack, which sets the bristle tufts of the toothbrush rotating.

Abstract: An electric toothbrush having separable handle and brush segments, a rotating motor shaft extending exteriorly of the handle segment, and a reciprocating toothed rack in the brush segment which engages and imparts a counter-rotating movement to a plurality of tufts on the brush head. A cylindrically shaped gear mounts to and is axially movable on the motor shaft when the brush and handle segments are attached together. First and second lifting cams configured as elliptical flanges lying in oblique planes are provided in radially spaced relationship on the exterior surface and interior bore hole of the gear, respectively. Respective first and second guide grooves are associated with the lifting cams and the reciprocal toothed rack whereby rotation of the gear generates a long stroke of the rack through the interaction of the first and second lifting cams and guide grooves.

Abstract: An electric toothbrush having in its slip-on brush a piston is disclosed, which is set rotating by a motor shaft projecting out of the handle segment. This piston exhibits a lifting cam, by means of which it effects an axial motion relative to the motor shaft in the slip-on brush. This axial motion causes a reciprocating motion of a toothed rack, which sets the bristle tufts of the toothbrush rotating.