Patents by Inventor Michael Birch
Michael Birch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11819503Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.Type: GrantFiled: April 22, 2020Date of Patent: November 21, 2023Assignees: F2G LtdInventors: Derek Law, John H. Rex, Michael Birch, Nathan P. Wiederhold, Thomas F. Patterson
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Patent number: 11065228Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: GrantFiled: February 10, 2020Date of Patent: July 20, 2021Assignee: F2G LimitedInventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
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Publication number: 20200338072Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.Type: ApplicationFiled: April 22, 2020Publication date: October 29, 2020Inventors: Derek LAW, John H. REX, Michael BIRCH
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Publication number: 20200179340Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: ApplicationFiled: February 10, 2020Publication date: June 11, 2020Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
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Patent number: 10596150Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: GrantFiled: December 17, 2018Date of Patent: March 24, 2020Assignee: F2G LIMITEDInventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
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Publication number: 20190314333Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: ApplicationFiled: December 17, 2018Publication date: October 17, 2019Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
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Patent number: 10201524Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: GrantFiled: November 20, 2015Date of Patent: February 12, 2019Assignee: F2G LIMITEDInventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
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Publication number: 20170340607Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamideor a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: ApplicationFiled: November 20, 2015Publication date: November 30, 2017Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
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Patent number: 9760192Abstract: A method and apparatus varying, by interval, a frequency of a drive signal applied to one electrode of each of a plurality of electrode pairs, select a frequency corresponding to the frequency of the drive signal, monitor changes in capacitance of each of the electrode pairs through receive signals at the selected frequency, from the other electrode of each of the plurality of electrode pairs; and determine a position of at least two objects, which are simultaneously on a touch device, according to the monitored capacitance changes.Type: GrantFiled: November 7, 2012Date of Patent: September 12, 2017Assignee: CYPRESS SEMICONDUCTOR CORPORATIONInventors: Jonathan R. Peterson, Robert Michael Birch
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Patent number: 9452168Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: February 18, 2015Date of Patent: September 27, 2016Assignee: F2G LTDInventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Michael Birch, Gareth Morse Davies
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Patent number: 9292122Abstract: An apparatus having a processing device for calibrating a touch-sensor device with calibration capacitors is described. Methods of calibrating the touch-sensor device using the same are also described. Processing device and multiple calibration capacitors are disposed on an integrated circuit (IC) die substrate. The processing device includes a measurement circuit to be coupled to a touch-sensor device and a switching circuit to selectively couple the calibration capacitors to the measurement circuit. The processing device is configured to calibrate the touch-sensor device by applying one or more capacitance touch values from one or more of the calibration capacitors using the switching circuit. The one or more capacitance touch values simulate a touch on the touch-sensor device.Type: GrantFiled: August 17, 2012Date of Patent: March 22, 2016Assignee: Cypress Semiconductor CorporationInventors: Andriy Maharyta, Robert Michael Birch
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Publication number: 20150238500Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: ApplicationFiled: February 18, 2015Publication date: August 27, 2015Inventors: Graham Edward Morris SIBLEY, Robert DOWNHAM, Lloyd James PAYNE, Derek LAW, Jason David OLIVER, Michael BIRCH, Gareth Morse DAVIES
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Patent number: 9034887Abstract: A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.Type: GrantFiled: May 1, 2009Date of Patent: May 19, 2015Assignee: F2G LimitedInventors: Jason David Oliver, John Leslie Thain, Michael John Bromley, Graham Edward Morris Sibley, Michael Birch
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Patent number: 8647573Abstract: An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.Type: GrantFiled: February 25, 2010Date of Patent: February 11, 2014Assignee: Lawrence Livermore National Security, LLCInventors: John Frederick Regan, James Michael Birch
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Patent number: 8248081Abstract: A single-layer touch-sensor device having a calibration mechanism coupled therewith is described. Included is a charge measurement circuit coupled, by a pair of electrical traces, with a slider of the single-layer touch-sensor device. A pair of calibration capacitors is included, each calibration capacitor coupled, between the slider and the charge measurement circuit, with one of the pair of electrical traces. A pair of connection switches is also included, each connection switch coupled with one of the pair of calibration capacitors.Type: GrantFiled: August 28, 2008Date of Patent: August 21, 2012Assignee: Cypress Semiconductor CorporationInventors: Andriy Maharyta, Robert Michael Birch
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Publication number: 20110183969Abstract: The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.Type: ApplicationFiled: May 29, 2009Publication date: July 28, 2011Inventors: Michael Birch, Graham Edward Morris Sibley, Derek Law, Jason David Oliver
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Publication number: 20110160231Abstract: A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.Type: ApplicationFiled: May 1, 2009Publication date: June 30, 2011Inventors: Jason David Oliver, John Leslie Thain, Michael John Bromley, Graham Edward Morris Sibley, Michael Birch
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Patent number: 7914266Abstract: A booster pumping system is disclosed for producing hydrocarbons from a subsea production well. The booster pumping system includes: (1) a submersible pump hydraulically connected to the production well to provide energy to the hydrocarbon flow and boost production to another destination such as a subsea production facility or the surface via a riser; (2) an inlet conduit to receive the flow from the production well and isolate the flow from the dummy wellbore and direct the flow to the intake of the pump; and (3) a motor exposed to the dummy wellbore to drive the pump. The dummy wellbore may be flooded or circulated with seawater to cool the motor.Type: GrantFiled: March 21, 2005Date of Patent: March 29, 2011Assignee: Schlumberger Technology CorporationInventors: John A. Kerr, Michael Birch, Joseph C. Scranton, Tauna Leonardi, Randall S. Vessels
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Publication number: 20100152885Abstract: An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.Type: ApplicationFiled: February 25, 2010Publication date: June 17, 2010Inventors: John Frederick Regan, James Michael Birch
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Patent number: D957811Type: GrantFiled: July 10, 2020Date of Patent: July 19, 2022Assignee: Kodiak Wildlife Products Inc.Inventor: Christopher Michael Birch