Patents by Inventor Michael Birch

Michael Birch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11819503
    Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: November 21, 2023
    Assignees: F2G Ltd
    Inventors: Derek Law, John H. Rex, Michael Birch, Nathan P. Wiederhold, Thomas F. Patterson
  • Patent number: 11065228
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: July 20, 2021
    Assignee: F2G Limited
    Inventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
  • Publication number: 20200338072
    Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.
    Type: Application
    Filed: April 22, 2020
    Publication date: October 29, 2020
    Inventors: Derek LAW, John H. REX, Michael BIRCH
  • Publication number: 20200179340
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: February 10, 2020
    Publication date: June 11, 2020
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Patent number: 10596150
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: March 24, 2020
    Assignee: F2G LIMITED
    Inventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
  • Publication number: 20190314333
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: December 17, 2018
    Publication date: October 17, 2019
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Patent number: 10201524
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 12, 2019
    Assignee: F2G LIMITED
    Inventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
  • Publication number: 20170340607
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamideor a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: November 20, 2015
    Publication date: November 30, 2017
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Patent number: 9760192
    Abstract: A method and apparatus varying, by interval, a frequency of a drive signal applied to one electrode of each of a plurality of electrode pairs, select a frequency corresponding to the frequency of the drive signal, monitor changes in capacitance of each of the electrode pairs through receive signals at the selected frequency, from the other electrode of each of the plurality of electrode pairs; and determine a position of at least two objects, which are simultaneously on a touch device, according to the monitored capacitance changes.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: September 12, 2017
    Assignee: CYPRESS SEMICONDUCTOR CORPORATION
    Inventors: Jonathan R. Peterson, Robert Michael Birch
  • Patent number: 9452168
    Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: September 27, 2016
    Assignee: F2G LTD
    Inventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Michael Birch, Gareth Morse Davies
  • Patent number: 9292122
    Abstract: An apparatus having a processing device for calibrating a touch-sensor device with calibration capacitors is described. Methods of calibrating the touch-sensor device using the same are also described. Processing device and multiple calibration capacitors are disposed on an integrated circuit (IC) die substrate. The processing device includes a measurement circuit to be coupled to a touch-sensor device and a switching circuit to selectively couple the calibration capacitors to the measurement circuit. The processing device is configured to calibrate the touch-sensor device by applying one or more capacitance touch values from one or more of the calibration capacitors using the switching circuit. The one or more capacitance touch values simulate a touch on the touch-sensor device.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: March 22, 2016
    Assignee: Cypress Semiconductor Corporation
    Inventors: Andriy Maharyta, Robert Michael Birch
  • Publication number: 20150238500
    Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 27, 2015
    Inventors: Graham Edward Morris SIBLEY, Robert DOWNHAM, Lloyd James PAYNE, Derek LAW, Jason David OLIVER, Michael BIRCH, Gareth Morse DAVIES
  • Patent number: 9034887
    Abstract: A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: May 19, 2015
    Assignee: F2G Limited
    Inventors: Jason David Oliver, John Leslie Thain, Michael John Bromley, Graham Edward Morris Sibley, Michael Birch
  • Patent number: 8647573
    Abstract: An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: February 11, 2014
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: John Frederick Regan, James Michael Birch
  • Patent number: 8248081
    Abstract: A single-layer touch-sensor device having a calibration mechanism coupled therewith is described. Included is a charge measurement circuit coupled, by a pair of electrical traces, with a slider of the single-layer touch-sensor device. A pair of calibration capacitors is included, each calibration capacitor coupled, between the slider and the charge measurement circuit, with one of the pair of electrical traces. A pair of connection switches is also included, each connection switch coupled with one of the pair of calibration capacitors.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: August 21, 2012
    Assignee: Cypress Semiconductor Corporation
    Inventors: Andriy Maharyta, Robert Michael Birch
  • Publication number: 20110183969
    Abstract: The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.
    Type: Application
    Filed: May 29, 2009
    Publication date: July 28, 2011
    Inventors: Michael Birch, Graham Edward Morris Sibley, Derek Law, Jason David Oliver
  • Publication number: 20110160231
    Abstract: A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
    Type: Application
    Filed: May 1, 2009
    Publication date: June 30, 2011
    Inventors: Jason David Oliver, John Leslie Thain, Michael John Bromley, Graham Edward Morris Sibley, Michael Birch
  • Patent number: 7914266
    Abstract: A booster pumping system is disclosed for producing hydrocarbons from a subsea production well. The booster pumping system includes: (1) a submersible pump hydraulically connected to the production well to provide energy to the hydrocarbon flow and boost production to another destination such as a subsea production facility or the surface via a riser; (2) an inlet conduit to receive the flow from the production well and isolate the flow from the dummy wellbore and direct the flow to the intake of the pump; and (3) a motor exposed to the dummy wellbore to drive the pump. The dummy wellbore may be flooded or circulated with seawater to cool the motor.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: March 29, 2011
    Assignee: Schlumberger Technology Corporation
    Inventors: John A. Kerr, Michael Birch, Joseph C. Scranton, Tauna Leonardi, Randall S. Vessels
  • Publication number: 20100152885
    Abstract: An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.
    Type: Application
    Filed: February 25, 2010
    Publication date: June 17, 2010
    Inventors: John Frederick Regan, James Michael Birch
  • Patent number: D957811
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: July 19, 2022
    Assignee: Kodiak Wildlife Products Inc.
    Inventor: Christopher Michael Birch