Abstract: A pluggable optical module, including: a body; a coldplate coupled to the body; and a pair of cooling fluid supply and return line quick disconnects coupled to the coldplate and extending from the coldplate and the body. Optionally, the coldplate is integrated into the body. Alternatively, the coldplate is coupled adjacent to an exterior surface of the body using one or more securement mechanisms, and a thermal interface material is disposed between the coldplate and the exterior surface of the body. The body and the coldplate are adapted to be inserted into a host card, circuit pack, or module as an integrated unit, with the pair of cooling fluid supply and return line quick disconnects adapted to fluidly engage a corresponding pair of cooling fluid supply and return line quick disconnects coupled to fluid supply and return manifolds or plenums disposed in the host card, circuit pack, or module.

Abstract: It is often important that a server's responses to a set of client requests are coherent with one another, but if the client's requests are spread over time, that may not occur. In accordance with the teaching of this patent document, a client is able to communicate with a server to achieve coherency. A client can send a request (e.g., an HTTP request for a given resource) with a data preservation directive. The data preservation directive causes the server to initiate a server-side process to preserve the state of underlying server-side data upon which the response relies (or will rely). Also, a client can send a request with an attribute requesting the response be coherent with respect to some date-time or other reference point. This attribute thus asks the server to ensure coherency in the response to the client.

Abstract: A cartridge for storing an un-labelled tissue to be imaged by an optical imaging system may include: a container to store the un-labelled tissue, and to interface with the optical imaging system; an optical substrate, provided on a bottom surface of the container, through which the optical imaging system is configured to image the un-labelled tissue to generate a virtually-stained histological image of the un-labelled tissue; and a lid, provided on a top surface of the container, including a membrane to compress the un-labelled tissue against the optical substrate such that an entire margin of the un-labelled tissue is flat against the optical substrate.

Abstract: A hybrid air/liquid-cooled network element including a backplane defining a plurality of holes, one or more printed circuit boards disposed on one side of the backplane, a plurality of fan units coupled to an opposite side of the backplane and adapted to circulate an air flow to components disposed on the printed circuit board(s) through certain of the plurality of holes defined by the backplane, and one or more coolant distribution manifold boxes coupled to the opposite side of the backplane adjacent to the plurality of fan units and adapted to circulate a coolant fluid flow to one or more cold plates disposed adjacent to components disposed on the printed circuit board(s) through other of the plurality of holes defined by the backplane, where the one or more coolant distribution manifold boxes each have height and width dimensions substantially the same as each of the plurality of fan units.

Abstract: Systems and methods for encrypting and decrypting data sent to and received from a peripheral device physically coupled to a hardware interface of a user equipment. In some examples, the user equipment may include an encrypting/decryption component that is configured to physically between a hardware interface of the user equipment and the other components of the user equipment. The encrypting/decryption component may be configured to receive a plurality of encryption/decryption schemes from a remote system. The encrypting/decryption component may select and apply one or more of the plurality of encryption/decryption schemes to data being downloaded and/or uploaded to the peripheral device.

Abstract: A network element include one or more modules each supporting one or more pluggable modules; and a first manifold and a second manifold each configured to connect to a conduit associated with a coldplate, wherein one of the first manifold and the second manifold is an inlet manifold and the other is an outlet manifold for a cooling fluid that flows through the conduit to cool the one or more pluggable modules. The one or more pluggable modules can be each a pluggable optical module that is one of compliant to any of XFP, SFP, XENPAK, X2, CFP, CFP2, CFP4, CFP8, QSFP, QSFP+, QSFP28, OSFP, and QSFP-DD and have a housing that has dimensions similar to any of XFP, SFP, XENPAK, X2, CFP, CFP2, CFP4, CFP8, QSFP, QSFP+, QSFP28, OSFP, and QSFP-DD.

Abstract: A pluggable optical module, including: a body; a coldplate coupled to the body; and a pair of cooling fluid supply and return line quick disconnects coupled to the coldplate and extending from the coldplate and the body. Optionally, the coldplate is integrated into the body. Alternatively, the coldplate is coupled adjacent to an exterior surface of the body using one or more securement mechanisms, and a thermal interface material is disposed between the coldplate and the exterior surface of the body. The body and the coldplate are adapted to be inserted into a host card, circuit pack, or module as an integrated unit, with the pair of cooling fluid supply and return line quick disconnects adapted to fluidly engage a corresponding pair of cooling fluid supply and return line quick disconnects coupled to fluid supply and return manifolds or plenums disposed in the host card, circuit pack, or module.

Abstract: A multi-tenant service platform provides network services, such as content delivery, edge compute, and/or media streaming, on behalf of, or directly for, a given tenant. The service platform offers a policy layer enabling each tenant to specify levels of acceptable performance degradation that the platform may incur so that the platform can use electricity with desirable characteristics to service client requests associated with that tenant. Service nodes in the platform (e.g., edge servers) enforce the policy layer at the time of a service request. Preferably, the ‘quality’ of the electricity is a measurement of source of the energy, e.g., whether it is sourced from high-carbon fossil fuels (low-quality) or low-carbon renewables (high-quality). If the desired quality of electricity cannot be achieved, the node can resort to using less electricity to handle the request, which is achieved in a variety of ways.

Abstract: It is often important that a server's responses to a set of client requests are coherent with one another, but if the client's requests are spread over time, that may not occur. In accordance with the teaching of this patent document, a client is able to communicate with a server to achieve coherency. A client can send a request (e.g., an HTTP request for a given resource) with a data preservation directive. The data preservation directive causes the server to initiate a server-side process to preserve the state of underlying server-side data upon which the response relies (or will rely). Also, a client can send a request with an attribute requesting the response be coherent with respect to some date-time or other reference point. This attribute thus asks the server to ensure coherency in the response to the client.

Abstract: A multi-tenant service platform provides network services, such as content delivery, edge compute, and/or media streaming, on behalf of, or directly for, a given tenant. The service platform offers a policy layer enabling each tenant to specify levels of acceptable performance degradation that the platform may incur so that the platform can use electricity with desirable characteristics to service client requests associated with that tenant. Service nodes in the platform (e.g., edge servers) enforce the policy layer at the time of a service request. Preferably, the ‘quality’ of the electricity is a measurement of source of the energy, e.g., whether it is sourced from high-carbon fossil fuels (low-quality) or low-carbon renewables (high-quality). If the desired quality of electricity cannot be achieved, the node can resort to using less electricity to handle the request, which is achieved in a variety of ways.

Abstract: An imaging apparatus may be used for histological and/or molecular imaging of a tissue sample. An imaging apparatus may include one or more light sources that generate one or more excitation beams directed toward an excitation location being focused on the sample to generate signals in the sample and one or more interrogation beams directed toward a detection location such that a portion of the one or more interrogation beams returning from the sample is indicative of at least some of the generated signals. An imaging apparatus may include a photodetector configured to detect radiative signals from the sample. An imaging apparatus may generate an image of the sample using only pressure (photoacoustic) signals, only temperature (photothermal) signals, and/or both photoacoustic and photothermal signals from the generated signals.

Abstract: The current disclosure provides for techniques and approaches for the generation of autologous mutant neoantigen-specific, TCR-engineered T cells used for adoptive transfer in treatment of cancer patients. Also provided are surrogate cancer cells, which is a personalized cell system that can be used for vaccination and TCR discovery in cancer patients.

Abstract: It is often important that a server's responses to a set of client requests are coherent with one another, but if the client's requests are spread over time, that may not occur. In accordance with the teaching of this patent document, a client is able to communicate with a server to achieve coherency. A client can send a request (e.g., an HTTP request for a given resource) with a data preservation directive. The data preservation directive causes the server to initiate a server-side process to preserve the state of underlying server-side data upon which the response relies (or will rely). Also, a client can send a request with an attribute requesting the response be coherent with respect to some date-time or other reference point. This attribute thus asks the server to ensure coherency in the response to the client.

Abstract: A networking hardware system includes a housing; a board located in the housing and comprising a plurality of components; a liquid cooled heat exchanger; and one or more fans disposed near the liquid cooled heat exchanger and configured to provide cool airflow from the liquid cooled heat exchanger to any of the plurality of components. The housing can be substantially sealed from an external environment and includes no air intake thereon, removing a need for higher powered fans and for air filtering for dust. The housing can include a faceplate with no air intake thereon, providing increased density for ports on the faceplate.

Abstract: An imaging apparatus may be used for histological and/or molecular imaging of a tissue sample. An imaging apparatus may include one or more light sources that generate one or more excitation beams directed toward an excitation location being focused on the sample to generate signals in the sample and one or more interrogation beams directed toward a detection location such that a portion of the one or more interrogation beams returning from the sample is indicative of at least some of the generated signals. An imaging apparatus may include a photodetector configured to detect radiative signals from the sample. An imaging apparatus may generate an image of the sample using only pressure (photoacoustic) signals, only temperature (photothermal) signals, and/or both photoacoustic and photothermal signals from the generated signals.

Abstract: A system for securing electronic devices includes a processor, non-transitory machine readable storage medium communicatively coupled to the processor, security applications, and a security controller. The security controller includes computer-executable instructions on the medium that are readable by the processor. The security application is configured to determine a suspicious file from a client using the security applications, identify whether the suspicious file has been encountered by other clients using the security applications, calculate a time range for which the suspicious file has been present on the clients, determine resources accessed by the suspicious file during the time range, and create a visualization of the suspicious file, a relationship between the suspicious file and the clients, the time range, and the resources accessed by the suspicious file during the time range.

Abstract: An imaging apparatus may be used for histological and/or molecular imaging of a tissue sample. An imaging apparatus may include one or more light sources that generate one or more excitation beams directed toward an excitation location being focused on the sample to generate signals in the sample and one or more interrogation beams directed toward a detection location such that a portion of the one or more interrogation beams returning from the sample is indicative of at least some of the generated signals. An imaging apparatus may include a photodetector configured to detect radiative signals from the sample. An imaging apparatus may generate an image of the sample using only pressure (photoacoustic) signals, only temperature (photothermal) signals, and/or both photoacoustic and photothermal signals from the generated signals.

Abstract: It is often important that a server's responses to a set of client requests are coherent with one another, but if the client's requests are spread over time, that may not occur. In accordance with the teaching of this patent document, a client is able to communicate with a server to achieve coherency. A client can send a request (e.g., an HTTP request for a given resource) with a data preservation directive. The data preservation directive causes the server to initiate a server-side process to preserve the state of underlying server-side data upon which the response relies (or will rely). Also, a client can send a request with an attribute requesting the response be coherent with respect to some date-time or other reference point. This attribute thus asks the server to ensure coherency in the response to the client.

Abstract: Compositions and methods for the treatment and amelioration of arterial stiffness, hypertension, and/or arterial aging in a subject. In embodiments, the active agents of the compositions provide anti-aging treatments by causing arterial remodeling by decreasing collagen production and increasing elastin production in a subject. In certain embodiments, the active agents can be used to treat a subject having diabetes or a diabetes-related disease or condition, such as but not limited to, Type 1 diabetes mellitus (T1DM), Type 2 diabetes mellitus (T2DM), and hyperinsulenima (pre-diabetes). In certain embodiments, the active agents can be used to treat subjects having hypertension, aortic disease, cardiovascular disease, including heart failure (such as congestive heart failure), kidney disease, osteoporosis, Alzheimer's disease, infertility, and emphysema.