Abstract: Methods of predicting whether or not a tumor will be responsive to IP6 treatment, methods of treating patients with cancer using IP6, methods of predicting the progression of a disease, and kits that facilitate these methods are disclosed.

Abstract: The present invention relates to methods of selectively treating a patient with skin squamous cell carcinoma are disclosed. Specifically, the methods comprise assessing whether or not the tumor will be responsive to IP6 treatment by using reduced INPP5A expression level as an indicator. The present invention further provides methods of assessing the progression of the disease, and kits that facilitate these methods as disclosed.

Abstract: Methods of predicting whether or not a tumor will be responsive to IP6 treatment, methods of treating patients with cancer using IP6, methods of predicting the progression of a disease, and kits that facilitate these methods are disclosed.

Abstract: An adjustment device for a vehicle component, in particular for the back rest of a vehicle seat, is proposed having a first fitting and a second fitting, wherein the relative position of the two fittings to one another can be changed by means of eccentric means, wherein a rotation of the eccentric means by means of a drive element is provided, wherein the adjustment device has a central element which is connected in a rotationally fixed fashion to the first fitting, wherein the drive element is provided mounted in an overlapping region by means of the central element.

Abstract: A frame member fastening device and method of manufacture provides a single configuration fastening device which can be used singly in connection with a frame member, or which can be combined with another identical fastening device to form a fastening device assembly for use with frame members of different internal widths, by interlocking two identical fastening devices in an opposed, base-to-base assembly configuration. The fastening device is manufactured in a progressive metal forming process with successive stages in which the features of the device are formed.

Abstract: A method for diagnosing an early stage melanoma which includes detecting the expression level of dual specificity phosphatase 1 protein (DUSP1) and a method for determining a prognosis for a subject having melanoma which includes detecting the expression level of DUSP1 are disclosed. Also disclosed are pharmaceutical compositions and kits comprised by these methods.

Abstract: In order to derive the temperature in the mesopause region from hydroxyl (OH*) airglow, in which intensities of three lines of OH* emission and a basic position are measured during the night using ground-based IR spectrometers, a noisy OH* spectrum is smoothed by filtering out white noise superimposed on the measured OH* intensities, by means of a spectral analysis method in the form of a harmonic analysis and by means of adaptation using the Voigt function which is carried out in the form of a combination of a Lorentz distribution and a Doppler distribution. A decision is made on the quality of the adaptation of the smoothed spectrum obtained to the original spectrum using statistical characteristic variables and by selecting one of the two methods, harmonic analysis function or Voigt function, and the temperature is thus accurately determined.

Abstract: Methods for assaying a sample for a probe polynucleotide are provided. The methods comprise forming a complex between a target on a substrate, the probe polynucleotide that binds to the target, and a conjugate comprising a semiconductor nanocrystal that binds to the probe polynucleotide by way of a tag sequence on the probe polynucleotide. The complex is formed when the probe polynucleotide is present in the sample. The methods are useful in any technique in which the detection of a target that can bind to a probe polynucleotide is desired, for example in fluorescence in situ hybridization. The methods are particularly useful in multiplex settings such as hybridization to microarrays where a plurality of targets are present. Assay complexes produced by such methods and kits useful for performing such methods are also provided.

Abstract: A frame member fastening device and method of manufacture provides a single configuration fastening device which can be used singly in connection with a frame member, or which can be combined with another identical fastening device to form a fastening device assembly for use with frame members of different internal widths, by interlocking two identical fastening devices in an opposed, base-to-base assembly configuration. The fastening device is manufactured in a progressive metal forming process with successive stages in which the features of the device are formed.

Abstract: In order to derive the temperature in the mesopause region from hydroxyl (OH*) airglow, in which intensities of three lines of OH* emission and a basic position are measured during the night using ground-based IR spectrometers, a noisy OH* spectrum is smoothed by filtering out white noise superimposed on the measured OH* intensities, by means of a spectral analysis method in the form of a harmonic analysis and by means of adaptation using the Voigt function which is carried out in the form of a combination of a Lorentz distribution and a Doppler distribution. A decision is made on the quality of the adaptation of the smoothed spectrum obtained to the original spectrum using statistical characteristic variables and by selecting one of the two methods, harmonic analysis function or Voigt function, and the temperature is thus accurately determined.

Abstract: The present invention describes methods for carrying out experiments on living cells, including making measurements of the operation transcriptional regulatory processes and indicators of the kinds of processes operating in the cell in response to external stimuli. Image analysis allows for gathering data concerning the flow of information through a cell's genomic regulatory network as it is executing a programmatic change in its activities as a function of said stimuli. The method also allows collection of data of the results of the information-processing in the cell by observing the decisions the cell makes when modulating cellular process activities.

Abstract: For the detection of geotectonic signals triggered by a geotectonic event, an infrasonic wave accompanying the geotectonic event and being generated at the ground and temperature fluctuations are utilized, causing a modulation of an airglow. The modulation of the airglow is detected from the ground by means of an infrared spectrometer and the mesopause temperature is measured with a high temporal resolution. For the detection of a geostationary event, a number of simultaneously operated infrared spectrometers is provided in regions sensitive to geotectonic events.

Abstract: The present invention describes methods for carrying out experiments on living cells, including making measurements of the operation transcriptional regulatory processes and indicators of the kinds of processes operating in the cell in response to external stimuli. Image analysis allows for gathering data concerning the flow of information through a cell's genomic regulatory network as it is executing a programmatic change in its activities as a function of said stimuli. The method also allows collection of data of the results of the information-processing in the cell by observing the decisions the cell makes when modulating cellular process activities.

Abstract: A connection assembly suitable for coupling a first component (42) to a second component (80) is provided. The connection assembly includes a first component having a projection (46). The projection has a peripheral surface that outwardly extends from the first component in a nonlinear manner. The connection assembly further includes a second component defining an aperture (86) for receiving the projection.

Abstract: The overexpression of certain marker genes including Wnt5a has been found useful in the identification of more aggressive forms of malignant melanoma. Therefore, the overexpression of these genes in tumor samples of malignant melanoma may be useful in the diagnosis, profiling, and treatment of patients suffering from this disease. Inhibitors of Wnt5a activity may be useful in the treatment of aggressive forms of malignant melanoma. Inhibition of Wnt5a activity may be effected by any method including anti-sense therapy, gene therapy, and pharmaceutical intervention.

Abstract: The overexpression of certain marker genes including Wnt5a has been found useful in the identification of more aggressive forms of malignant melanoma. Therefore, the overexpression of these genes in tumor samples of malignant melanoma may be useful in the diagnosis, profiling, and treatment of patients suffering from this disease. Inhibitors of Wnt5a activity may be useful in the treatment of aggressive forms of malignant melanoma. Inhibition of Wnt5a activity may be effected by any method including anti-sense therapy, gene therapy, and pharmaceutical intervention.

Abstract: Narrative structure and a free-form database to support biological storytelling. An interactive software system provides a framework, methodology, and tools for organizing information during speculative phases of research using a narrative structure. The system provides interactive tools and techniques for organizing, sharing, and using diverse information at multiple levels of abstraction through coordinated multiple-view visualization in the process of hypothesis formation. Items are created or imported through an item manager and can be grouped into collections using a collection manager. Items and collections are combined in a narrative structure through pathway and story editors. Annotation and collaboration are supported.

Abstract: An interactive software system provides a framework, methodology, and tools for organizing information during speculative phases of research using a narrative structure. The system provides interactive tools and techniques for organizing, sharing, and using diverse information at multiple levels of abstraction through coordinated multiple-view visualization in the process of hypothesis formation. Annotation and collaboration are supported.

Abstract: The inventive process for correcting atmospheric influences in multispectral optical remote sensing data, which are acquired as raw data in satellite or airborne sensors for earth observation, comprises the combination of a pre-classification (DERA) of the raw data for an automatic identification of predefined classes, a correction calculation (CORA) for a conversion of the uncorrected to corrected reflectances on the ground, including an incorporation of current atmospheric data for a precise description of the atmospheric condition. The pre-classification (DERA) permits a more precise correction calculation (CORA) by generating required a priori knowledge. The method has applications in satellite or airborne remote sensing of the earth's surface.

Abstract: Methods for assaying a sample for a probe polynucleotide are provided. The methods comprise forming a complex between a target on a substrate, the probe polynucleotide that binds to the target, and a conjugate comprising a semiconductor nanocrystal that binds to the probe polynucleotide by way of a tag sequence on the probe polynucleotide. The complex is formed when the probe polynucleotide is present in the sample. The methods are useful in any technique in which the detection of a target that can bind to a probe polynucleotide is desired, for example in fluorescence in situ hybridization. The methods are particularly useful in multiplex settings such as hybridization to microarrays where a plurality of targets are present. Assay complexes produced by such methods and kits useful for performing such methods are also provided.